The Role of Centrosome Distal Appendage Proteins (DAPs) in Nephronophthisis and Ciliogenesis

The Role of Centrosome Distal Appendage Proteins (DAPs) in Nephronophthisis and Ciliogenesis

The primary cilium is found in most mammalian cells and plays a functional role in tissue homeostasis and organ development by modulating key signaling pathways. Ciliopathies are a group of genetically heterogeneous disorders resulting from defects in cilia development and function. Patients with ci...

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Bibliographic Details
Main Authors: Fatma Mansour, Felix J. Boivin, Iman B. Shaheed, Markus Schueler, Kai M. Schmidt-Ott
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
distal appendages
centrosome
ciliogenesis
transition fibers
nephronophthisis
Online Access:https://www.mdpi.com/1422-0067/22/22/12253

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