Sustained-release losartan from peptide nanofibers promotes chondrogenesis

Sustained-release losartan from peptide nanofibers promotes chondrogenesis

Introduction: The central pathologic feature of osteoarthritis (OA) is the progressive loss of articular cartilage, which has a limited regenerative capacity. The TGF-β1 inhibitor, losartan, can improve cartilage repair by promoting hyaline rather that fibrous cartilage tissue regeneration. However,...

Full description

Bibliographic Details
Main Authors: Kohei Yamaura, Nicholas A. Sather, Anna Metlushko, Haruki Nishimura, Radoslav Z. Pavlović, Sealy Hambright, Sudheer K. Ravuri, Marc J. Philippon, Samuel I. Stupp, Chelsea S. Bahney, Johnny Huard
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
osteoarthritis
chondrocytes
losartan
peptide amphiphile nanofibers
sustained release
TGF-β
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1122456/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2023.1122456/full

Similar Items