Rice koji reduced body weight gain, fat accumulation, and blood glucose level in high-fat diet-induced obese mice
Rice koji is considered a readily accessible functional food that may have health-promoting effects. We investigated whether white, yellow, and red koji have the anti-obesity effect in C57BL/6J mice fed a high-fat diet (HFD), which is a model for obesity. Mice were fed HFD containing 10% (w/w) of ri...
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PeerJ Inc.
2014-08-01
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| Online Access: | https://peerj.com/articles/540.pdf |
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| author | Yumiko Yoshizaki Chihiro Kawasaki Kai-Chun Cheng Miharu Ushikai Haruka Amitani Akihiro Asakawa Kayu Okutsu Yoshihiro Sameshima Kazunori Takamine Akio Inui |
| author_facet | Yumiko Yoshizaki Chihiro Kawasaki Kai-Chun Cheng Miharu Ushikai Haruka Amitani Akihiro Asakawa Kayu Okutsu Yoshihiro Sameshima Kazunori Takamine Akio Inui |
| author_sort | Yumiko Yoshizaki |
| collection | DOAJ |
| description | Rice koji is considered a readily accessible functional food that may have health-promoting effects. We investigated whether white, yellow, and red koji have the anti-obesity effect in C57BL/6J mice fed a high-fat diet (HFD), which is a model for obesity. Mice were fed HFD containing 10% (w/w) of rice koji powder or steamed rice for 4 weeks. Weight gain, epididymal white adipose tissue, and total adipose tissue weight were significantly lower in all rice koji groups than in the HFD-rice group after 4 weeks. Feed efficiency was significantly reduced in the yellow koji group. Blood glucose levels were significantly lower in the white and red koji groups with HOMA-R and leptin levels being reduced in the white koji group. White and red koji increased glucose uptake and GLUT4 protein expression in L6 myotube cells. These results showed that all rice koji have the anti-obesity or anti-diabetes effects although the mechanisms may differ depending on the type of rice koji consumed. |
| first_indexed | 2024-03-09T06:39:07Z |
| format | Article |
| id | doaj.art-46c1816e6ad9423fa9e11bb5325d8e43 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:39:07Z |
| publishDate | 2014-08-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-46c1816e6ad9423fa9e11bb5325d8e432023-12-03T10:54:10ZengPeerJ Inc.PeerJ2167-83592014-08-012e54010.7717/peerj.540540Rice koji reduced body weight gain, fat accumulation, and blood glucose level in high-fat diet-induced obese miceYumiko Yoshizaki0Chihiro Kawasaki1Kai-Chun Cheng2Miharu Ushikai3Haruka Amitani4Akihiro Asakawa5Kayu Okutsu6Yoshihiro Sameshima7Kazunori Takamine8Akio Inui9Division of Shochu Fermentation Technology, Education and Research Center for Fermentation Studies, Faculty of Agriculture, Kagoshima University, Kagoshima City, JapanDivision of Shochu Fermentation Technology, Education and Research Center for Fermentation Studies, Faculty of Agriculture, Kagoshima University, Kagoshima City, JapanDepartment of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima City, JapanDepartment of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima City, JapanDepartment of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima City, JapanDepartment of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima City, JapanDivision of Shochu Fermentation Technology, Education and Research Center for Fermentation Studies, Faculty of Agriculture, Kagoshima University, Kagoshima City, JapanDivision of Shochu Fermentation Technology, Education and Research Center for Fermentation Studies, Faculty of Agriculture, Kagoshima University, Kagoshima City, JapanDivision of Shochu Fermentation Technology, Education and Research Center for Fermentation Studies, Faculty of Agriculture, Kagoshima University, Kagoshima City, JapanDepartment of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima City, JapanRice koji is considered a readily accessible functional food that may have health-promoting effects. We investigated whether white, yellow, and red koji have the anti-obesity effect in C57BL/6J mice fed a high-fat diet (HFD), which is a model for obesity. Mice were fed HFD containing 10% (w/w) of rice koji powder or steamed rice for 4 weeks. Weight gain, epididymal white adipose tissue, and total adipose tissue weight were significantly lower in all rice koji groups than in the HFD-rice group after 4 weeks. Feed efficiency was significantly reduced in the yellow koji group. Blood glucose levels were significantly lower in the white and red koji groups with HOMA-R and leptin levels being reduced in the white koji group. White and red koji increased glucose uptake and GLUT4 protein expression in L6 myotube cells. These results showed that all rice koji have the anti-obesity or anti-diabetes effects although the mechanisms may differ depending on the type of rice koji consumed.https://peerj.com/articles/540.pdfGLUT4High-fat dietAntiobesityMiceRice koji |
| spellingShingle | Yumiko Yoshizaki Chihiro Kawasaki Kai-Chun Cheng Miharu Ushikai Haruka Amitani Akihiro Asakawa Kayu Okutsu Yoshihiro Sameshima Kazunori Takamine Akio Inui Rice koji reduced body weight gain, fat accumulation, and blood glucose level in high-fat diet-induced obese mice PeerJ GLUT4 High-fat diet Antiobesity Mice Rice koji |
| title | Rice koji reduced body weight gain, fat accumulation, and blood glucose level in high-fat diet-induced obese mice |
| title_full | Rice koji reduced body weight gain, fat accumulation, and blood glucose level in high-fat diet-induced obese mice |
| title_fullStr | Rice koji reduced body weight gain, fat accumulation, and blood glucose level in high-fat diet-induced obese mice |
| title_full_unstemmed | Rice koji reduced body weight gain, fat accumulation, and blood glucose level in high-fat diet-induced obese mice |
| title_short | Rice koji reduced body weight gain, fat accumulation, and blood glucose level in high-fat diet-induced obese mice |
| title_sort | rice koji reduced body weight gain fat accumulation and blood glucose level in high fat diet induced obese mice |
| topic | GLUT4 High-fat diet Antiobesity Mice Rice koji |
| url | https://peerj.com/articles/540.pdf |
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