Id4 promotes the elimination of the pro-activation factor Ascl1 to maintain quiescence of adult hippocampal stem cells

Id4 promotes the elimination of the pro-activation factor Ascl1 to maintain quiescence of adult hippocampal stem cells

Quiescence is essential for the long-term maintenance of adult stem cells but how stem cells maintain quiescence is poorly understood. Here, we show that neural stem cells (NSCs) in the adult mouse hippocampus actively transcribe the pro-activation factor Ascl1 regardless of their activated or quies...

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Bibliographic Details
Main Authors: Isabelle Maria Blomfield, Brenda Rocamonde, Maria del Mar Masdeu, Eskeatnaf Mulugeta, Stefania Vaga, Debbie LC van den Berg, Emmanuelle Huillard, François Guillemot, Noelia Urbán
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-09-01
Series:eLife
Subjects:
adult neurogenesis
hippocampus
adult stem cell
ID proteins
quiescence
Online Access:https://elifesciences.org/articles/48561

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