Orientia tsutsugamushi: comprehensive analysis of the mobilome of a highly fragmented and repetitive genome reveals the capacity for ongoing lateral gene transfer in an obligate intracellular bacterium

Orientia tsutsugamushi: comprehensive analysis of the mobilome of a highly fragmented and repetitive genome reveals the capacity for ongoing lateral gene transfer in an obligate intracellular bacterium

ABSTRACTThe rickettsial human pathogen Orientia tsutsugamushi (Ot) is an obligate intracellular Gram-negative bacterium with one of the most highly fragmented and repetitive genomes of any organism. Around 50% of its ~2.3-Mb genome is composed of repetitive DNA that is derived from the highly prolif...

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Bibliographic Details
Main Authors: Suparat Giengkam, Chitrasak Kullapanich, Jantana Wongsantichon, Haley E. Adcox, Joseph J. Gillespie, Jeanne Salje
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:mSphere
Subjects:
Orientia tsutsugamushi
Rickettsiales
obligate intracellular bacteria
intracellular pathogens
mobile genetic elements
comparative genomics
Online Access:https://journals.asm.org/doi/10.1128/msphere.00268-23

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