Prohibitin-induced obesity leads to anovulation and polycystic ovary in mice

Prohibitin-induced obesity leads to anovulation and polycystic ovary in mice

Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder and the most common cause of female infertility. However, its etiology and underlying mechanisms remain unclear. Here we report that a transgenic obese mouse (Mito-Ob) developed by overexpressing prohibitin in adipocytes develops pol...

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Bibliographic Details
Main Authors: Sudharsana Rao Ande, Khanh Hoa Nguyen, Yang Xin Zi Xu, Suresh Mishra
Format: Article
Language:English
Published: The Company of Biologists 2017-06-01
Series:Biology Open
Subjects:
Transgenic models
Periovarian adipose tissue
Cystic ovary
Female infertility
Online Access:http://bio.biologists.org/content/6/6/825

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