Sinus histiocytosis (Rosai- Dorfman disease) presenting with solitary cutaneous nodule: a very rare clinical entity

Sinus histiocytosis is a rare inflammatory disease mainly affecting the cervical lymph nodes, presenting with skin lesions in 10% of cases. Our patient had a solitary nodule on the trunk without any other clinical signs. The histology reported a dermal neoplasm composed mainly of macrophages and lym...

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Main Authors: Emilia Duarte-Williamson, Fiona Antony, Radu Rotarescu
Format: Article
Language:English
Published: Mattioli1885 2012-04-01
Series:Dermatology Practical & Conceptual
Subjects:
Online Access:http://dpcj.org/index.php/dpc/article/view/991
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author Emilia Duarte-Williamson
Fiona Antony
Radu Rotarescu
author_facet Emilia Duarte-Williamson
Fiona Antony
Radu Rotarescu
author_sort Emilia Duarte-Williamson
collection DOAJ
description Sinus histiocytosis is a rare inflammatory disease mainly affecting the cervical lymph nodes, presenting with skin lesions in 10% of cases. Our patient had a solitary nodule on the trunk without any other clinical signs. The histology reported a dermal neoplasm composed mainly of macrophages and lymphocytes. Macrophages were aggregated in clusters resembling lymph node sinuses. Lymphophagocytosis or emperipolesis (the presence of an intact cell within the cytoplasm of another cell) was noted and the diagnosis of sinus histiocytosis established.
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spelling doaj.art-46c5bf0393584f15bacadbd1dbfbfb702022-12-21T21:09:38ZengMattioli1885Dermatology Practical & Conceptual2160-93812012-04-01Sinus histiocytosis (Rosai- Dorfman disease) presenting with solitary cutaneous nodule: a very rare clinical entityEmilia Duarte-Williamson0Fiona Antony1Radu Rotarescu2Dermatology Department, Kent and Canterbury Hospital, Canterbury, Kent, UKDermatology Department, Frimley Park Hospital, Frimley, Surrey, UKDermatology Department, Stafford General Hospital, Stafford, Staffordshire, UKSinus histiocytosis is a rare inflammatory disease mainly affecting the cervical lymph nodes, presenting with skin lesions in 10% of cases. Our patient had a solitary nodule on the trunk without any other clinical signs. The histology reported a dermal neoplasm composed mainly of macrophages and lymphocytes. Macrophages were aggregated in clusters resembling lymph node sinuses. Lymphophagocytosis or emperipolesis (the presence of an intact cell within the cytoplasm of another cell) was noted and the diagnosis of sinus histiocytosis established.http://dpcj.org/index.php/dpc/article/view/991histiocytosissinus histiocytosisRosai-Dorfmannodule
spellingShingle Emilia Duarte-Williamson
Fiona Antony
Radu Rotarescu
Sinus histiocytosis (Rosai- Dorfman disease) presenting with solitary cutaneous nodule: a very rare clinical entity
Dermatology Practical & Conceptual
histiocytosis
sinus histiocytosis
Rosai-Dorfman
nodule
title Sinus histiocytosis (Rosai- Dorfman disease) presenting with solitary cutaneous nodule: a very rare clinical entity
title_full Sinus histiocytosis (Rosai- Dorfman disease) presenting with solitary cutaneous nodule: a very rare clinical entity
title_fullStr Sinus histiocytosis (Rosai- Dorfman disease) presenting with solitary cutaneous nodule: a very rare clinical entity
title_full_unstemmed Sinus histiocytosis (Rosai- Dorfman disease) presenting with solitary cutaneous nodule: a very rare clinical entity
title_short Sinus histiocytosis (Rosai- Dorfman disease) presenting with solitary cutaneous nodule: a very rare clinical entity
title_sort sinus histiocytosis rosai dorfman disease presenting with solitary cutaneous nodule a very rare clinical entity
topic histiocytosis
sinus histiocytosis
Rosai-Dorfman
nodule
url http://dpcj.org/index.php/dpc/article/view/991
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