Sinus histiocytosis (Rosai- Dorfman disease) presenting with solitary cutaneous nodule: a very rare clinical entity
Sinus histiocytosis is a rare inflammatory disease mainly affecting the cervical lymph nodes, presenting with skin lesions in 10% of cases. Our patient had a solitary nodule on the trunk without any other clinical signs. The histology reported a dermal neoplasm composed mainly of macrophages and lym...
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Format: | Article |
Language: | English |
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Mattioli1885
2012-04-01
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Series: | Dermatology Practical & Conceptual |
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Online Access: | http://dpcj.org/index.php/dpc/article/view/991 |
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author | Emilia Duarte-Williamson Fiona Antony Radu Rotarescu |
author_facet | Emilia Duarte-Williamson Fiona Antony Radu Rotarescu |
author_sort | Emilia Duarte-Williamson |
collection | DOAJ |
description | Sinus histiocytosis is a rare inflammatory disease mainly affecting the cervical lymph nodes, presenting with skin lesions in 10% of cases. Our patient had a solitary nodule on the trunk without any other clinical signs. The histology reported a dermal neoplasm composed mainly of macrophages and lymphocytes. Macrophages were aggregated in clusters resembling lymph node sinuses. Lymphophagocytosis or emperipolesis (the presence of an intact cell within the cytoplasm of another cell) was noted and the diagnosis of sinus histiocytosis established. |
first_indexed | 2024-12-18T11:29:16Z |
format | Article |
id | doaj.art-46c5bf0393584f15bacadbd1dbfbfb70 |
institution | Directory Open Access Journal |
issn | 2160-9381 |
language | English |
last_indexed | 2024-12-18T11:29:16Z |
publishDate | 2012-04-01 |
publisher | Mattioli1885 |
record_format | Article |
series | Dermatology Practical & Conceptual |
spelling | doaj.art-46c5bf0393584f15bacadbd1dbfbfb702022-12-21T21:09:38ZengMattioli1885Dermatology Practical & Conceptual2160-93812012-04-01Sinus histiocytosis (Rosai- Dorfman disease) presenting with solitary cutaneous nodule: a very rare clinical entityEmilia Duarte-Williamson0Fiona Antony1Radu Rotarescu2Dermatology Department, Kent and Canterbury Hospital, Canterbury, Kent, UKDermatology Department, Frimley Park Hospital, Frimley, Surrey, UKDermatology Department, Stafford General Hospital, Stafford, Staffordshire, UKSinus histiocytosis is a rare inflammatory disease mainly affecting the cervical lymph nodes, presenting with skin lesions in 10% of cases. Our patient had a solitary nodule on the trunk without any other clinical signs. The histology reported a dermal neoplasm composed mainly of macrophages and lymphocytes. Macrophages were aggregated in clusters resembling lymph node sinuses. Lymphophagocytosis or emperipolesis (the presence of an intact cell within the cytoplasm of another cell) was noted and the diagnosis of sinus histiocytosis established.http://dpcj.org/index.php/dpc/article/view/991histiocytosissinus histiocytosisRosai-Dorfmannodule |
spellingShingle | Emilia Duarte-Williamson Fiona Antony Radu Rotarescu Sinus histiocytosis (Rosai- Dorfman disease) presenting with solitary cutaneous nodule: a very rare clinical entity Dermatology Practical & Conceptual histiocytosis sinus histiocytosis Rosai-Dorfman nodule |
title | Sinus histiocytosis (Rosai- Dorfman disease) presenting with solitary cutaneous nodule: a very rare clinical entity |
title_full | Sinus histiocytosis (Rosai- Dorfman disease) presenting with solitary cutaneous nodule: a very rare clinical entity |
title_fullStr | Sinus histiocytosis (Rosai- Dorfman disease) presenting with solitary cutaneous nodule: a very rare clinical entity |
title_full_unstemmed | Sinus histiocytosis (Rosai- Dorfman disease) presenting with solitary cutaneous nodule: a very rare clinical entity |
title_short | Sinus histiocytosis (Rosai- Dorfman disease) presenting with solitary cutaneous nodule: a very rare clinical entity |
title_sort | sinus histiocytosis rosai dorfman disease presenting with solitary cutaneous nodule a very rare clinical entity |
topic | histiocytosis sinus histiocytosis Rosai-Dorfman nodule |
url | http://dpcj.org/index.php/dpc/article/view/991 |
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