Associations between serum calcium, 25(OH)D level and bone mineral density in adolescents
Abstract Backgrounds It is important to improve our understanding of the roles of calcium and vitamin D in bone health for preventing osteoporosis. We aimed at exploring the associations between serum calcium, vitamin D level, and bone mineral density (BMD) in adolescents included in the National He...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-03-01
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| Series: | Advances in Rheumatology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42358-021-00174-8 |
| _version_ | 1818915431550812160 |
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| author | Kaiyu Pan Rongliang Tu Xiaocong Yao Zhongxin Zhu |
| author_facet | Kaiyu Pan Rongliang Tu Xiaocong Yao Zhongxin Zhu |
| author_sort | Kaiyu Pan |
| collection | DOAJ |
| description | Abstract Backgrounds It is important to improve our understanding of the roles of calcium and vitamin D in bone health for preventing osteoporosis. We aimed at exploring the associations between serum calcium, vitamin D level, and bone mineral density (BMD) in adolescents included in the National Health and Nutrition Examination Survey (NHANES) 2001–2006. Methods Weighted multivariate linear regression models were used to estimate the associations of serum calcium, 25(OH)D level with total BMD. Smooth curve fitting was used to explore the potential non-linear relationship. Results A total of 5990 individuals aged between 12 and 19 years were included in this study. The fully-adjusted model showed serum calcium positively correlated with total BMD. However, an inverted U-shaped relationship was found when we performed the smooth curve fitting method, and the inflection point was calculated at 9.6 mg/dL using the two-piecewise linear regression model. In contrast, there was a positive correlation between serum 25(OH)D and total BMD after adjusting for potential confounders. Conclusions The present study revealed a positive correlation between serum 25(OH)D level and total BMD, and an inverted U-shaped relationship between serum calcium and total BMD. |
| first_indexed | 2024-12-20T00:02:10Z |
| format | Article |
| id | doaj.art-46c8ab6e606a44078cf0a04405616f34 |
| institution | Directory Open Access Journal |
| issn | 2523-3106 |
| language | English |
| last_indexed | 2024-12-20T00:02:10Z |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Advances in Rheumatology |
| spelling | doaj.art-46c8ab6e606a44078cf0a04405616f342022-12-21T20:00:48ZengBMCAdvances in Rheumatology2523-31062021-03-016111910.1186/s42358-021-00174-8Associations between serum calcium, 25(OH)D level and bone mineral density in adolescentsKaiyu Pan0Rongliang Tu1Xiaocong Yao2Zhongxin Zhu3Department of Paediatrics, Xiaoshan Affiliated Hospital of Wenzhou Medical UniversityDepartment of Paediatrics, Zhejiang Xiaoshan HospitalDepartment of Osteoporosis Care and Control, Xiaoshan Affiliated Hospital of Wenzhou Medical UniversityDepartment of Osteoporosis Care and Control, Xiaoshan Affiliated Hospital of Wenzhou Medical UniversityAbstract Backgrounds It is important to improve our understanding of the roles of calcium and vitamin D in bone health for preventing osteoporosis. We aimed at exploring the associations between serum calcium, vitamin D level, and bone mineral density (BMD) in adolescents included in the National Health and Nutrition Examination Survey (NHANES) 2001–2006. Methods Weighted multivariate linear regression models were used to estimate the associations of serum calcium, 25(OH)D level with total BMD. Smooth curve fitting was used to explore the potential non-linear relationship. Results A total of 5990 individuals aged between 12 and 19 years were included in this study. The fully-adjusted model showed serum calcium positively correlated with total BMD. However, an inverted U-shaped relationship was found when we performed the smooth curve fitting method, and the inflection point was calculated at 9.6 mg/dL using the two-piecewise linear regression model. In contrast, there was a positive correlation between serum 25(OH)D and total BMD after adjusting for potential confounders. Conclusions The present study revealed a positive correlation between serum 25(OH)D level and total BMD, and an inverted U-shaped relationship between serum calcium and total BMD.https://doi.org/10.1186/s42358-021-00174-8CalciumVitamin DBone healthAdolescentNHANES |
| spellingShingle | Kaiyu Pan Rongliang Tu Xiaocong Yao Zhongxin Zhu Associations between serum calcium, 25(OH)D level and bone mineral density in adolescents Advances in Rheumatology Calcium Vitamin D Bone health Adolescent NHANES |
| title | Associations between serum calcium, 25(OH)D level and bone mineral density in adolescents |
| title_full | Associations between serum calcium, 25(OH)D level and bone mineral density in adolescents |
| title_fullStr | Associations between serum calcium, 25(OH)D level and bone mineral density in adolescents |
| title_full_unstemmed | Associations between serum calcium, 25(OH)D level and bone mineral density in adolescents |
| title_short | Associations between serum calcium, 25(OH)D level and bone mineral density in adolescents |
| title_sort | associations between serum calcium 25 oh d level and bone mineral density in adolescents |
| topic | Calcium Vitamin D Bone health Adolescent NHANES |
| url | https://doi.org/10.1186/s42358-021-00174-8 |
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