Synthesis and anti-oxidant activity of coumarinyl chalcones
Abstract Background The ability to inhibit oxidative stress has been established as the prime mechanism in treatment of several disease conditions. In view of this, two new series of coumarin–chalcone hybrid molecules (5a–o and 6a–o) were synthesized using various aromatic aldehydes. The structures...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-09-01
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| Series: | Future Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43094-021-00340-1 |
| _version_ | 1818826203787689984 |
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| author | Raj Keshwar Prasad Kavita R. Loksh |
| author_facet | Raj Keshwar Prasad Kavita R. Loksh |
| author_sort | Raj Keshwar Prasad |
| collection | DOAJ |
| description | Abstract Background The ability to inhibit oxidative stress has been established as the prime mechanism in treatment of several disease conditions. In view of this, two new series of coumarin–chalcone hybrid molecules (5a–o and 6a–o) were synthesized using various aromatic aldehydes. The structures of the compounds were confirmed using IR, 1HNMR and mass spectral analyses. The compounds were evaluated for their antioxidant potential against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radicals in scavenging assays. Results Compounds 5o and 5k exhibited significant antioxidant potential as compared to the standard drug (ascorbic acid). Conclusions It can be concluded that the coumarin–chalcone treatment have the potential to be optimized further to generate scaffolds capable to treat many pathological conditions. |
| first_indexed | 2024-12-19T00:23:56Z |
| format | Article |
| id | doaj.art-46c9661d7258405db5cb7dfda7d1dc05 |
| institution | Directory Open Access Journal |
| issn | 2314-7253 |
| language | English |
| last_indexed | 2024-12-19T00:23:56Z |
| publishDate | 2021-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Future Journal of Pharmaceutical Sciences |
| spelling | doaj.art-46c9661d7258405db5cb7dfda7d1dc052022-12-21T20:45:24ZengSpringerOpenFuture Journal of Pharmaceutical Sciences2314-72532021-09-017111210.1186/s43094-021-00340-1Synthesis and anti-oxidant activity of coumarinyl chalconesRaj Keshwar Prasad0Kavita R. Loksh1Department of Pharmacy, Oriental UniversityDepartment of Pharmacy, Oriental UniversityAbstract Background The ability to inhibit oxidative stress has been established as the prime mechanism in treatment of several disease conditions. In view of this, two new series of coumarin–chalcone hybrid molecules (5a–o and 6a–o) were synthesized using various aromatic aldehydes. The structures of the compounds were confirmed using IR, 1HNMR and mass spectral analyses. The compounds were evaluated for their antioxidant potential against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radicals in scavenging assays. Results Compounds 5o and 5k exhibited significant antioxidant potential as compared to the standard drug (ascorbic acid). Conclusions It can be concluded that the coumarin–chalcone treatment have the potential to be optimized further to generate scaffolds capable to treat many pathological conditions.https://doi.org/10.1186/s43094-021-00340-1CoumarinChalconeAntioxidantFree radicalVilsmeier–HaackClaisen–Schmidt condensation |
| spellingShingle | Raj Keshwar Prasad Kavita R. Loksh Synthesis and anti-oxidant activity of coumarinyl chalcones Future Journal of Pharmaceutical Sciences Coumarin Chalcone Antioxidant Free radical Vilsmeier–Haack Claisen–Schmidt condensation |
| title | Synthesis and anti-oxidant activity of coumarinyl chalcones |
| title_full | Synthesis and anti-oxidant activity of coumarinyl chalcones |
| title_fullStr | Synthesis and anti-oxidant activity of coumarinyl chalcones |
| title_full_unstemmed | Synthesis and anti-oxidant activity of coumarinyl chalcones |
| title_short | Synthesis and anti-oxidant activity of coumarinyl chalcones |
| title_sort | synthesis and anti oxidant activity of coumarinyl chalcones |
| topic | Coumarin Chalcone Antioxidant Free radical Vilsmeier–Haack Claisen–Schmidt condensation |
| url | https://doi.org/10.1186/s43094-021-00340-1 |
| work_keys_str_mv | AT rajkeshwarprasad synthesisandantioxidantactivityofcoumarinylchalcones AT kavitarloksh synthesisandantioxidantactivityofcoumarinylchalcones |