An Electrochemical Approach for the Selective Detection of Cancer Metabolic Creatine Biomarker with Porous Nano-Formulated CMNO Materials Decorated Glassy Carbon Electrode
The facile wet-chemical technique was used to prepare the low-dimensional nano-formulated porous mixed metal oxide nanomaterials (CuO.Mn<sub>2</sub>O<sub>3</sub>.NiO; CMNO NMs) in an alkaline medium at low temperature. Detailed structural, morphological, crystalline, and func...
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MDPI AG
2020-12-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/20/24/7060 |
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| author | Mohammed M. Rahman Md. M. Alam Abdullah M. Asiri Firoz. A. D. M. Opo |
| author_facet | Mohammed M. Rahman Md. M. Alam Abdullah M. Asiri Firoz. A. D. M. Opo |
| author_sort | Mohammed M. Rahman |
| collection | DOAJ |
| description | The facile wet-chemical technique was used to prepare the low-dimensional nano-formulated porous mixed metal oxide nanomaterials (CuO.Mn<sub>2</sub>O<sub>3</sub>.NiO; CMNO NMs) in an alkaline medium at low temperature. Detailed structural, morphological, crystalline, and functional characterization of CMNO NMs were performed by X-ray photoelectron spectroscopy (XPS), powder X-ray diffraction (XRD), ultraviolet-visible spectroscopy (UV-vis), Fourier-transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), and energy-dispersive X-ray spectroscopy (EDS) analyses. An efficient and selective creatine (CA) sensor probe was fabricated by using CMNO NMs decorated onto glassy carbon electrode (GCE) as CMNO NMs/GCE by using Nafion adhesive (5% suspension in ethanol). The relation of current versus the concentration of CA was plotted to draw a calibration curve of the CMNO NMs/GCE sensor probe, which was found to have a very linear value (r<sup>2</sup> = 0.9995) over a large dynamic range (LDR: 0.1 nM~0.1 mM) for selective CA detection. The slope of LDR by considering the active surface area of GCE (0.0316 cm<sup>2</sup>) was applied to estimate the sensor sensitivity (14.6308 µAµM<sup>−1</sup> cm<sup>−2</sup>). Moreover, the detection limit (21.63 ± 0.05 pM) of CMNO MNs modified GCE was calculated from the signal/noise (S/N) ratio at 3. As a CA sensor probe, it exhibited long-term stability, good reproducibility, and fast response time in the detection of CA by electrochemical approach. Therefore, this research technique is introduced as a promising platform to develop an efficient sensor probe for cancer metabolic biomarker by using nano-formulated mixed metal oxides for biochemical as well as biomedical research for the safety of health care fields. |
| first_indexed | 2024-03-10T14:11:35Z |
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| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-03-10T14:11:35Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
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| series | Sensors |
| spelling | doaj.art-46c99990cfa0430396462b70df3667bf2023-11-21T00:06:39ZengMDPI AGSensors1424-82202020-12-012024706010.3390/s20247060An Electrochemical Approach for the Selective Detection of Cancer Metabolic Creatine Biomarker with Porous Nano-Formulated CMNO Materials Decorated Glassy Carbon ElectrodeMohammed M. Rahman0Md. M. Alam1Abdullah M. Asiri2Firoz. A. D. M. Opo3Center of Excellence for Advanced Materials Research (CEAMR), King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi ArabiaDepartment of Chemical Engineering and Polymer Science, Shahjalal University of Science and Technology, Sylhet 3100, BangladeshCenter of Excellence for Advanced Materials Research (CEAMR), King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi ArabiaDepartment of Biomedical Science, College of Natural Sciences, Chosun University, Chosun 61452, KoreaThe facile wet-chemical technique was used to prepare the low-dimensional nano-formulated porous mixed metal oxide nanomaterials (CuO.Mn<sub>2</sub>O<sub>3</sub>.NiO; CMNO NMs) in an alkaline medium at low temperature. Detailed structural, morphological, crystalline, and functional characterization of CMNO NMs were performed by X-ray photoelectron spectroscopy (XPS), powder X-ray diffraction (XRD), ultraviolet-visible spectroscopy (UV-vis), Fourier-transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), and energy-dispersive X-ray spectroscopy (EDS) analyses. An efficient and selective creatine (CA) sensor probe was fabricated by using CMNO NMs decorated onto glassy carbon electrode (GCE) as CMNO NMs/GCE by using Nafion adhesive (5% suspension in ethanol). The relation of current versus the concentration of CA was plotted to draw a calibration curve of the CMNO NMs/GCE sensor probe, which was found to have a very linear value (r<sup>2</sup> = 0.9995) over a large dynamic range (LDR: 0.1 nM~0.1 mM) for selective CA detection. The slope of LDR by considering the active surface area of GCE (0.0316 cm<sup>2</sup>) was applied to estimate the sensor sensitivity (14.6308 µAµM<sup>−1</sup> cm<sup>−2</sup>). Moreover, the detection limit (21.63 ± 0.05 pM) of CMNO MNs modified GCE was calculated from the signal/noise (S/N) ratio at 3. As a CA sensor probe, it exhibited long-term stability, good reproducibility, and fast response time in the detection of CA by electrochemical approach. Therefore, this research technique is introduced as a promising platform to develop an efficient sensor probe for cancer metabolic biomarker by using nano-formulated mixed metal oxides for biochemical as well as biomedical research for the safety of health care fields.https://www.mdpi.com/1424-8220/20/24/7060porous nano-formulated CMNO nanomaterialscreatine sensorwet-chemical techniqueglassy carbon electrodeclinical researchhealth care field |
| spellingShingle | Mohammed M. Rahman Md. M. Alam Abdullah M. Asiri Firoz. A. D. M. Opo An Electrochemical Approach for the Selective Detection of Cancer Metabolic Creatine Biomarker with Porous Nano-Formulated CMNO Materials Decorated Glassy Carbon Electrode Sensors porous nano-formulated CMNO nanomaterials creatine sensor wet-chemical technique glassy carbon electrode clinical research health care field |
| title | An Electrochemical Approach for the Selective Detection of Cancer Metabolic Creatine Biomarker with Porous Nano-Formulated CMNO Materials Decorated Glassy Carbon Electrode |
| title_full | An Electrochemical Approach for the Selective Detection of Cancer Metabolic Creatine Biomarker with Porous Nano-Formulated CMNO Materials Decorated Glassy Carbon Electrode |
| title_fullStr | An Electrochemical Approach for the Selective Detection of Cancer Metabolic Creatine Biomarker with Porous Nano-Formulated CMNO Materials Decorated Glassy Carbon Electrode |
| title_full_unstemmed | An Electrochemical Approach for the Selective Detection of Cancer Metabolic Creatine Biomarker with Porous Nano-Formulated CMNO Materials Decorated Glassy Carbon Electrode |
| title_short | An Electrochemical Approach for the Selective Detection of Cancer Metabolic Creatine Biomarker with Porous Nano-Formulated CMNO Materials Decorated Glassy Carbon Electrode |
| title_sort | electrochemical approach for the selective detection of cancer metabolic creatine biomarker with porous nano formulated cmno materials decorated glassy carbon electrode |
| topic | porous nano-formulated CMNO nanomaterials creatine sensor wet-chemical technique glassy carbon electrode clinical research health care field |
| url | https://www.mdpi.com/1424-8220/20/24/7060 |
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