Role of the complex enzyme immunoassay testing in diagnosing uveitis in the presence of herpetic infection
Background: In recurrent uveitis, establishing whether any herpetic infection has played an etiological or triggering role in the disease is important for selecting the appropriate treatment. Purpose: To assess the results of complex enzyme immunoassay testing (CEIAT) performed for patients with...
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| Format: | Article |
| Language: | English |
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Ukrainian Society of Ophthalmologists
2015-07-01
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| Series: | Journal of Ophthalmology |
| Subjects: | |
| Online Access: | https://www.ozhurnal.com/en/archive/2015/4/2-fulltext |
| _version_ | 1797354145878900736 |
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| author | S.R. Medjidova |
| author_facet | S.R. Medjidova |
| author_sort | S.R. Medjidova |
| collection | DOAJ |
| description | Background: In recurrent uveitis, establishing whether any herpetic infection has played an etiological or triggering role in the disease is important for selecting the appropriate treatment.
Purpose: To assess the results of complex enzyme immunoassay testing (CEIAT) performed for patients with both uveitis and herpes simplex virus (HSV) infection in the process of treatment.
Materials and Methods: In 73 uveitis patients, the CEIAT was used to determine serum levels of anti?HSV-IgМ and anti?HSV-IgG antibodies (Ab) to herpes simplex virus type 1 and type 2 (HSV1&2), IgG class Ab to nonstructural early viral antigens of HSV1&2, and the avidity of specific IgG Ab to HSV1&2.
Results: The most common etiology of uveitis was herpetic infection (25.7%). In 74.3% of cases, HSV played a triggering role. The following three types of specific immunity were registered: (1) significantly (р<0.01) increased levels of anti-HSV IgM and anti?HSV-IgG Ab and IgG class Ab to nonstructural early viral antigens, with the avidity index (AI) values exceeding 50% (27 patients), (2) the most increased (р<0.001) levels of anti?HSV-IgG Ab and IgG class Ab to nonstructural early viral antigens, with the AI values exceeding 50% (35 patients), and (3) only the level of IgG class Ab to nonstructural early viral antigens is slightly increased (р<0.05), with high AI values (12 patients). The third type of immune response was as a manifestation of the immune tolerance of the human body, with the most clinically severe course of the inflammatory process.
Conclusion: In uveitis in the presence of HSV infection, the results of the CEIAT provide the practitioner an opportunity to investigate the activity of inflammatory process and define a pathogenetically sound scheme to correct the alterations revealed. |
| first_indexed | 2024-03-08T13:46:15Z |
| format | Article |
| id | doaj.art-46c9a5f0c4fd4699a6fe8dc0c94ea4b0 |
| institution | Directory Open Access Journal |
| issn | 2412-8740 |
| language | English |
| last_indexed | 2024-03-08T13:46:15Z |
| publishDate | 2015-07-01 |
| publisher | Ukrainian Society of Ophthalmologists |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj.art-46c9a5f0c4fd4699a6fe8dc0c94ea4b02024-01-16T09:16:54ZengUkrainian Society of OphthalmologistsJournal of Ophthalmology2412-87402015-07-014111610.31288/oftalmolzh201541116Role of the complex enzyme immunoassay testing in diagnosing uveitis in the presence of herpetic infectionS.R. Medjidova0Acad. Z. Alieva National Center of OphthalmologyBackground: In recurrent uveitis, establishing whether any herpetic infection has played an etiological or triggering role in the disease is important for selecting the appropriate treatment. Purpose: To assess the results of complex enzyme immunoassay testing (CEIAT) performed for patients with both uveitis and herpes simplex virus (HSV) infection in the process of treatment. Materials and Methods: In 73 uveitis patients, the CEIAT was used to determine serum levels of anti?HSV-IgМ and anti?HSV-IgG antibodies (Ab) to herpes simplex virus type 1 and type 2 (HSV1&2), IgG class Ab to nonstructural early viral antigens of HSV1&2, and the avidity of specific IgG Ab to HSV1&2. Results: The most common etiology of uveitis was herpetic infection (25.7%). In 74.3% of cases, HSV played a triggering role. The following three types of specific immunity were registered: (1) significantly (р<0.01) increased levels of anti-HSV IgM and anti?HSV-IgG Ab and IgG class Ab to nonstructural early viral antigens, with the avidity index (AI) values exceeding 50% (27 patients), (2) the most increased (р<0.001) levels of anti?HSV-IgG Ab and IgG class Ab to nonstructural early viral antigens, with the AI values exceeding 50% (35 patients), and (3) only the level of IgG class Ab to nonstructural early viral antigens is slightly increased (р<0.05), with high AI values (12 patients). The third type of immune response was as a manifestation of the immune tolerance of the human body, with the most clinically severe course of the inflammatory process. Conclusion: In uveitis in the presence of HSV infection, the results of the CEIAT provide the practitioner an opportunity to investigate the activity of inflammatory process and define a pathogenetically sound scheme to correct the alterations revealed.https://www.ozhurnal.com/en/archive/2015/4/2-fulltextuveitidesherpes simplex viruscomplex enzyme immunoassay testing |
| spellingShingle | S.R. Medjidova Role of the complex enzyme immunoassay testing in diagnosing uveitis in the presence of herpetic infection Journal of Ophthalmology uveitides herpes simplex virus complex enzyme immunoassay testing |
| title | Role of the complex enzyme immunoassay testing in diagnosing uveitis in the presence of herpetic infection |
| title_full | Role of the complex enzyme immunoassay testing in diagnosing uveitis in the presence of herpetic infection |
| title_fullStr | Role of the complex enzyme immunoassay testing in diagnosing uveitis in the presence of herpetic infection |
| title_full_unstemmed | Role of the complex enzyme immunoassay testing in diagnosing uveitis in the presence of herpetic infection |
| title_short | Role of the complex enzyme immunoassay testing in diagnosing uveitis in the presence of herpetic infection |
| title_sort | role of the complex enzyme immunoassay testing in diagnosing uveitis in the presence of herpetic infection |
| topic | uveitides herpes simplex virus complex enzyme immunoassay testing |
| url | https://www.ozhurnal.com/en/archive/2015/4/2-fulltext |
| work_keys_str_mv | AT srmedjidova roleofthecomplexenzymeimmunoassaytestingindiagnosinguveitisinthepresenceofherpeticinfection |