Preparation, Characterization and In Vitro Biological Activities of New Diphenylsulphone Derived Schiff Base Ligands and Their Co(II) Complexes
The present work describes the chemical preparation of Schiff bases derived from 4,4′-diaminodiphenyl sulfone (L<sub>1</sub>–L<sub>5</sub>) and their Co(II) metal complexes. The evaluation of antimicrobial and anticancer activities against MCF-7 cell line and human lung cance...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/23/8576 |
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| author | Kundalkesha D. Gaikwad Panchsheela Ubale Rahul Khobragade Sachin Deodware Pratibha Dhale Mahadev R. Asabe Rekha M. Ovhal Pranav Singh Prashant Vishwanath Chandan Shivamallu Raghu Ram Achar Ekaterina Silina Victor Stupin Natalia Manturova Ali A. Shati Mohammad Y. Alfaifi Serag Eldin I. Elbehairi Shashikant H. Gaikwad Shiva Prasad Kollur |
| author_facet | Kundalkesha D. Gaikwad Panchsheela Ubale Rahul Khobragade Sachin Deodware Pratibha Dhale Mahadev R. Asabe Rekha M. Ovhal Pranav Singh Prashant Vishwanath Chandan Shivamallu Raghu Ram Achar Ekaterina Silina Victor Stupin Natalia Manturova Ali A. Shati Mohammad Y. Alfaifi Serag Eldin I. Elbehairi Shashikant H. Gaikwad Shiva Prasad Kollur |
| author_sort | Kundalkesha D. Gaikwad |
| collection | DOAJ |
| description | The present work describes the chemical preparation of Schiff bases derived from 4,4′-diaminodiphenyl sulfone (L<sub>1</sub>–L<sub>5</sub>) and their Co(II) metal complexes. The evaluation of antimicrobial and anticancer activities against MCF-7 cell line and human lung cancer cell line A-549 was performed. The aforementioned synthesized compounds are characterized by spectroscopic techniques and elemental analysis confirms successful synthesis. The results from the above analytical techniques revealed that the complexes are in an octahedral geometry. The antimicrobial activity of the synthesized Schiff base ligands and their metal complexes under study was carried out by using the agar well diffusion method. The ligand and complex interactions for biological targets were predicted using molecular docking and high binding affinities. Further, the anticancer properties of the synthesized compounds are performed against the MCF-7 cell line and human lung cancer cell line A-549 using adriamycin as the standard drug. |
| first_indexed | 2024-03-09T17:38:35Z |
| format | Article |
| id | doaj.art-46cc6b7c397b48a0b600b03b31acf82a |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T17:38:35Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-46cc6b7c397b48a0b600b03b31acf82a2023-11-24T11:44:28ZengMDPI AGMolecules1420-30492022-12-012723857610.3390/molecules27238576Preparation, Characterization and In Vitro Biological Activities of New Diphenylsulphone Derived Schiff Base Ligands and Their Co(II) ComplexesKundalkesha D. Gaikwad0Panchsheela Ubale1Rahul Khobragade2Sachin Deodware3Pratibha Dhale4Mahadev R. Asabe5Rekha M. Ovhal6Pranav Singh7Prashant Vishwanath8Chandan Shivamallu9Raghu Ram Achar10Ekaterina Silina11Victor Stupin12Natalia Manturova13Ali A. Shati14Mohammad Y. Alfaifi15Serag Eldin I. Elbehairi16Shashikant H. Gaikwad17Shiva Prasad Kollur18Department of Chemistry, Sangameshawar College, Solapur 413 001, IndiaDepartment of Chemistry, N. K. Orchid College of Engineering and Technology, Solapur 413 002, IndiaDepartment of Microbiology, Dr. Babasaheb Ambedkar Marathwada University, Sub Campus, Osmanabad 413 501, IndiaChemistry Research Laboratory, Department of Chemistry, Shri Shivaji Mahavidyalaya, Solapur 413 411, IndiaChemistry Research Laboratory, Department of Chemistry, Shri Shivaji Mahavidyalaya, Solapur 413 411, IndiaDepartment of Chemistry, Walchand College of Art and Science, Solapur 413 006, IndiaDepartment of Chemistry, Walchand College of Art and Science, Solapur 413 006, IndiaDepartment of Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Udupi 576 104, IndiaCentre for Excellence in Molecular Biology and Regenerative Medicine, Department of Biochemistry, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru 570 015, IndiaDepartment of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru 570 015, IndiaDivision of Biochemistry, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru 570 015, IndiaDepartment of Hospital Surgery, N.I. Pirogov Russian National Research Medical University, Moscow 117997, RussiaDepartment of Hospital Surgery, N.I. Pirogov Russian National Research Medical University, Moscow 117997, RussiaDepartment of Hospital Surgery, N.I. Pirogov Russian National Research Medical University, Moscow 117997, RussiaBiology Department, Faculty of Science, King Khalid University, Abha 9004, Saudi ArabiaBiology Department, Faculty of Science, King Khalid University, Abha 9004, Saudi ArabiaBiology Department, Faculty of Science, King Khalid University, Abha 9004, Saudi ArabiaChemistry Research Laboratory, Department of Chemistry, Shri Shivaji Mahavidyalaya, Solapur 413 411, IndiaSchool of Physical Sciences, Amrita Vishwa Vidyapeetham, Mysuru Campus, Mysuru 570 026, IndiaThe present work describes the chemical preparation of Schiff bases derived from 4,4′-diaminodiphenyl sulfone (L<sub>1</sub>–L<sub>5</sub>) and their Co(II) metal complexes. The evaluation of antimicrobial and anticancer activities against MCF-7 cell line and human lung cancer cell line A-549 was performed. The aforementioned synthesized compounds are characterized by spectroscopic techniques and elemental analysis confirms successful synthesis. The results from the above analytical techniques revealed that the complexes are in an octahedral geometry. The antimicrobial activity of the synthesized Schiff base ligands and their metal complexes under study was carried out by using the agar well diffusion method. The ligand and complex interactions for biological targets were predicted using molecular docking and high binding affinities. Further, the anticancer properties of the synthesized compounds are performed against the MCF-7 cell line and human lung cancer cell line A-549 using adriamycin as the standard drug.https://www.mdpi.com/1420-3049/27/23/85764,4′-diaminodiphenyl sulfoneSchiff baseCo(II) complexantimicrobialanticancer activity |
| spellingShingle | Kundalkesha D. Gaikwad Panchsheela Ubale Rahul Khobragade Sachin Deodware Pratibha Dhale Mahadev R. Asabe Rekha M. Ovhal Pranav Singh Prashant Vishwanath Chandan Shivamallu Raghu Ram Achar Ekaterina Silina Victor Stupin Natalia Manturova Ali A. Shati Mohammad Y. Alfaifi Serag Eldin I. Elbehairi Shashikant H. Gaikwad Shiva Prasad Kollur Preparation, Characterization and In Vitro Biological Activities of New Diphenylsulphone Derived Schiff Base Ligands and Their Co(II) Complexes Molecules 4,4′-diaminodiphenyl sulfone Schiff base Co(II) complex antimicrobial anticancer activity |
| title | Preparation, Characterization and In Vitro Biological Activities of New Diphenylsulphone Derived Schiff Base Ligands and Their Co(II) Complexes |
| title_full | Preparation, Characterization and In Vitro Biological Activities of New Diphenylsulphone Derived Schiff Base Ligands and Their Co(II) Complexes |
| title_fullStr | Preparation, Characterization and In Vitro Biological Activities of New Diphenylsulphone Derived Schiff Base Ligands and Their Co(II) Complexes |
| title_full_unstemmed | Preparation, Characterization and In Vitro Biological Activities of New Diphenylsulphone Derived Schiff Base Ligands and Their Co(II) Complexes |
| title_short | Preparation, Characterization and In Vitro Biological Activities of New Diphenylsulphone Derived Schiff Base Ligands and Their Co(II) Complexes |
| title_sort | preparation characterization and in vitro biological activities of new diphenylsulphone derived schiff base ligands and their co ii complexes |
| topic | 4,4′-diaminodiphenyl sulfone Schiff base Co(II) complex antimicrobial anticancer activity |
| url | https://www.mdpi.com/1420-3049/27/23/8576 |
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