Role of macrophages in cardiorenal syndrome development in patients with myocardial infarction
Cardiorenal syndrome (CRS) in patients with acute myocardial infarction (MI) underlies the development and progression of renal and heart failure. Along with the well-known mechanisms of CRS development based on reninangiotensin system activation, kidney-heart macrophage axis may be one of the key c...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
| Published: |
«FIRMA «SILICEA» LLC
2021-05-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/4309 |
| _version_ | 1797856675610230784 |
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| author | M. A. Kercheva V. V. Ryabov |
| author_facet | M. A. Kercheva V. V. Ryabov |
| author_sort | M. A. Kercheva |
| collection | DOAJ |
| description | Cardiorenal syndrome (CRS) in patients with acute myocardial infarction (MI) underlies the development and progression of renal and heart failure. Along with the well-known mechanisms of CRS development based on reninangiotensin system activation, kidney-heart macrophage axis may be one of the key cellular components of CRS. Continuous sympathetic stimulation of collecting duct system cells under ischemia activates the macrophage link of the kidneys, which contributes to cardiac macrophages' polarization and leads to the development of adaptive myocardial hypertrophy and fibrosis. This review article summarizes current data on interaction of macrophages in the kidney-heart axis, which can be considered as the cellular basis for CRS development in patients with MI. The translation of experimental data on the participation of innate immune system on CRS model in humans will make it possible to find new ways to prevent and suppress acute kidney injury in patients with MI. |
| first_indexed | 2024-04-09T20:44:24Z |
| format | Article |
| id | doaj.art-46cea147427a4a259daa3282c042f2a0 |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2024-04-09T20:44:24Z |
| publishDate | 2021-05-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-46cea147427a4a259daa3282c042f2a02023-03-29T21:23:38Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202021-05-0126410.15829/1560-4071-2021-43093214Role of macrophages in cardiorenal syndrome development in patients with myocardial infarctionM. A. Kercheva0V. V. Ryabov1Siberian State Medical University; Cardiology Research Institute, Tomsk National Research Medical CenterSiberian State Medical University; Cardiology Research Institute, Tomsk National Research Medical Center; National Research Tomsk State UniversityCardiorenal syndrome (CRS) in patients with acute myocardial infarction (MI) underlies the development and progression of renal and heart failure. Along with the well-known mechanisms of CRS development based on reninangiotensin system activation, kidney-heart macrophage axis may be one of the key cellular components of CRS. Continuous sympathetic stimulation of collecting duct system cells under ischemia activates the macrophage link of the kidneys, which contributes to cardiac macrophages' polarization and leads to the development of adaptive myocardial hypertrophy and fibrosis. This review article summarizes current data on interaction of macrophages in the kidney-heart axis, which can be considered as the cellular basis for CRS development in patients with MI. The translation of experimental data on the participation of innate immune system on CRS model in humans will make it possible to find new ways to prevent and suppress acute kidney injury in patients with MI.https://russjcardiol.elpub.ru/jour/article/view/4309myocardial infarctioncardiorenal syndromemacrophagesheart failureheart remodeling |
| spellingShingle | M. A. Kercheva V. V. Ryabov Role of macrophages in cardiorenal syndrome development in patients with myocardial infarction Российский кардиологический журнал myocardial infarction cardiorenal syndrome macrophages heart failure heart remodeling |
| title | Role of macrophages in cardiorenal syndrome development in patients with myocardial infarction |
| title_full | Role of macrophages in cardiorenal syndrome development in patients with myocardial infarction |
| title_fullStr | Role of macrophages in cardiorenal syndrome development in patients with myocardial infarction |
| title_full_unstemmed | Role of macrophages in cardiorenal syndrome development in patients with myocardial infarction |
| title_short | Role of macrophages in cardiorenal syndrome development in patients with myocardial infarction |
| title_sort | role of macrophages in cardiorenal syndrome development in patients with myocardial infarction |
| topic | myocardial infarction cardiorenal syndrome macrophages heart failure heart remodeling |
| url | https://russjcardiol.elpub.ru/jour/article/view/4309 |
| work_keys_str_mv | AT makercheva roleofmacrophagesincardiorenalsyndromedevelopmentinpatientswithmyocardialinfarction AT vvryabov roleofmacrophagesincardiorenalsyndromedevelopmentinpatientswithmyocardialinfarction |