Antimutagenic effect of genistein
A great variety of health benefits including the protection against breast and prostate cancers has been attributed to the soya consumption, because of the presence of soy beans isoflavones, genistein, and others. We investigated the antigenotoxic effect of genistein on the genotoxicity of three mut...
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| Format: | Article |
| Language: | English |
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Czech Academy of Agricultural Sciences
2006-06-01
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| Series: | Czech Journal of Food Sciences |
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| Online Access: | https://cjfs.agriculturejournals.cz/artkey/cjf-200603-0003_antimutagenic-effect-of-genistein.php |
| _version_ | 1797899803924889600 |
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| author | Zdeňka Polívková Martina Langová Petr Šmerák Jiřina Bártová Ivo Bárta |
| author_facet | Zdeňka Polívková Martina Langová Petr Šmerák Jiřina Bártová Ivo Bárta |
| author_sort | Zdeňka Polívková |
| collection | DOAJ |
| description | A great variety of health benefits including the protection against breast and prostate cancers has been attributed to the soya consumption, because of the presence of soy beans isoflavones, genistein, and others. We investigated the antigenotoxic effect of genistein on the genotoxicity of three mutagens and carcinogens - aflatoxine B1 (AFB1), 2-amino-3-methylimidazo [4,5-f]quinoline (IQ), and N-nitroso-N-methylurea (MNU), using the Ames bacterial mutagenicity test and the micronucleus test. In the Ames test on Salmonella typhimurium, a significant antimutagenic effect was determined against the indirect mutagen AFB1 in two strains, TA98 and TA100. However, the effect on the IQ indirect mutagenicity was more pronounced in the test with TA98 than with TA100. The mutagenicity of the direct mutagen MNU was suppressed by genistein only at its highest concentration used (300 µg/plate). The protective effect of genistein against all three mutagens was proved in the micronucleus test as the treatment of mice with the combinations of genistein and mutagens resulted in a significant reduction of the number of micronuclei in comparison with the number of micronuclei induced by the individual mutagens alone. |
| first_indexed | 2024-04-10T08:35:45Z |
| format | Article |
| id | doaj.art-46cfccd6abc74eda9e86c26cf73da312 |
| institution | Directory Open Access Journal |
| issn | 1212-1800 1805-9317 |
| language | English |
| last_indexed | 2024-04-10T08:35:45Z |
| publishDate | 2006-06-01 |
| publisher | Czech Academy of Agricultural Sciences |
| record_format | Article |
| series | Czech Journal of Food Sciences |
| spelling | doaj.art-46cfccd6abc74eda9e86c26cf73da3122023-02-23T03:27:01ZengCzech Academy of Agricultural SciencesCzech Journal of Food Sciences1212-18001805-93172006-06-0124311912610.17221/3306-CJFScjf-200603-0003Antimutagenic effect of genisteinZdeňka Polívková0Martina Langová1Petr Šmerák2Jiřina Bártová3Ivo Bárta4Division of General Biology and Genetics, Center of Biomedical Sciences andDivision of General Biology and Genetics, Center of Biomedical Sciences andDivision of General Biology and Genetics, Center of Biomedical Sciences andDivision of General Hygiene, Center of Preventive Medicine, 3 rd Faculty of Medicine, Charles University, Prague, Czech RepublicDivision of General Biology and Genetics, Center of Biomedical Sciences andA great variety of health benefits including the protection against breast and prostate cancers has been attributed to the soya consumption, because of the presence of soy beans isoflavones, genistein, and others. We investigated the antigenotoxic effect of genistein on the genotoxicity of three mutagens and carcinogens - aflatoxine B1 (AFB1), 2-amino-3-methylimidazo [4,5-f]quinoline (IQ), and N-nitroso-N-methylurea (MNU), using the Ames bacterial mutagenicity test and the micronucleus test. In the Ames test on Salmonella typhimurium, a significant antimutagenic effect was determined against the indirect mutagen AFB1 in two strains, TA98 and TA100. However, the effect on the IQ indirect mutagenicity was more pronounced in the test with TA98 than with TA100. The mutagenicity of the direct mutagen MNU was suppressed by genistein only at its highest concentration used (300 µg/plate). The protective effect of genistein against all three mutagens was proved in the micronucleus test as the treatment of mice with the combinations of genistein and mutagens resulted in a significant reduction of the number of micronuclei in comparison with the number of micronuclei induced by the individual mutagens alone.https://cjfs.agriculturejournals.cz/artkey/cjf-200603-0003_antimutagenic-effect-of-genistein.phpchemopreventionaflatoxin b12-amino-3-methylimidazo [4,5-f]quinolinen-nitroso-n-methylureaames testmicronucleus test |
| spellingShingle | Zdeňka Polívková Martina Langová Petr Šmerák Jiřina Bártová Ivo Bárta Antimutagenic effect of genistein Czech Journal of Food Sciences chemoprevention aflatoxin b1 2-amino-3-methylimidazo [4,5-f]quinoline n-nitroso-n-methylurea ames test micronucleus test |
| title | Antimutagenic effect of genistein |
| title_full | Antimutagenic effect of genistein |
| title_fullStr | Antimutagenic effect of genistein |
| title_full_unstemmed | Antimutagenic effect of genistein |
| title_short | Antimutagenic effect of genistein |
| title_sort | antimutagenic effect of genistein |
| topic | chemoprevention aflatoxin b1 2-amino-3-methylimidazo [4,5-f]quinoline n-nitroso-n-methylurea ames test micronucleus test |
| url | https://cjfs.agriculturejournals.cz/artkey/cjf-200603-0003_antimutagenic-effect-of-genistein.php |
| work_keys_str_mv | AT zdenkapolivkova antimutageniceffectofgenistein AT martinalangova antimutageniceffectofgenistein AT petrsmerak antimutageniceffectofgenistein AT jirinabartova antimutageniceffectofgenistein AT ivobarta antimutageniceffectofgenistein |