Non-coding RNAs in cancer therapy-induced cardiotoxicity: Mechanisms, biomarkers, and treatments
As a result of ongoing breakthroughs in cancer therapy, cancer patients' survival rates have grown considerably. However, cardiotoxicity has emerged as the most dangerous toxic side effect of cancer treatment, negatively impacting cancer patients' prognosis. In recent years, the link betwe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.946137/full |
| _version_ | 1828148882728550400 |
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| author | Wanli Sun Juping Xu Li Wang Yuchen Jiang Jingrun Cui Xin Su Fan Yang Li Tian Zeyu Si Yanwei Xing |
| author_facet | Wanli Sun Juping Xu Li Wang Yuchen Jiang Jingrun Cui Xin Su Fan Yang Li Tian Zeyu Si Yanwei Xing |
| author_sort | Wanli Sun |
| collection | DOAJ |
| description | As a result of ongoing breakthroughs in cancer therapy, cancer patients' survival rates have grown considerably. However, cardiotoxicity has emerged as the most dangerous toxic side effect of cancer treatment, negatively impacting cancer patients' prognosis. In recent years, the link between non-coding RNAs (ncRNAs) and cancer therapy-induced cardiotoxicity has received much attention and investigation. NcRNAs are non-protein-coding RNAs that impact gene expression post-transcriptionally. They include microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). In several cancer treatments, such as chemotherapy, radiotherapy, and targeted therapy-induced cardiotoxicity, ncRNAs play a significant role in the onset and progression of cardiotoxicity. This review focuses on the mechanisms of ncRNAs in cancer therapy-induced cardiotoxicity, including apoptosis, mitochondrial damage, oxidative stress, DNA damage, inflammation, autophagy, aging, calcium homeostasis, vascular homeostasis, and fibrosis. In addition, this review explores potential ncRNAs-based biomarkers and therapeutic strategies, which may help to convert ncRNAs research into clinical practice in the future for early detection and improvement of cancer therapy-induced cardiotoxicity. |
| first_indexed | 2024-04-11T21:22:06Z |
| format | Article |
| id | doaj.art-46d334d7d03b4fbeb3d54efaababf5ed |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-11T21:22:06Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-46d334d7d03b4fbeb3d54efaababf5ed2022-12-22T04:02:35ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-08-01910.3389/fcvm.2022.946137946137Non-coding RNAs in cancer therapy-induced cardiotoxicity: Mechanisms, biomarkers, and treatmentsWanli Sun0Juping Xu1Li Wang2Yuchen Jiang3Jingrun Cui4Xin Su5Fan Yang6Li Tian7Zeyu Si8Yanwei Xing9Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaThe Second People's Hospital of Jiaozuo, Jiaozuo, ChinaDepartment of Breast Surgery, Xingtai People's Hospital, Xingtai, ChinaGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaBeijing University of Chinese Medicine, Beijing, ChinaThe First Clinical Medical College of Shaanxi University of Chinese Medicine, Taiyuan, ChinaGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaAs a result of ongoing breakthroughs in cancer therapy, cancer patients' survival rates have grown considerably. However, cardiotoxicity has emerged as the most dangerous toxic side effect of cancer treatment, negatively impacting cancer patients' prognosis. In recent years, the link between non-coding RNAs (ncRNAs) and cancer therapy-induced cardiotoxicity has received much attention and investigation. NcRNAs are non-protein-coding RNAs that impact gene expression post-transcriptionally. They include microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). In several cancer treatments, such as chemotherapy, radiotherapy, and targeted therapy-induced cardiotoxicity, ncRNAs play a significant role in the onset and progression of cardiotoxicity. This review focuses on the mechanisms of ncRNAs in cancer therapy-induced cardiotoxicity, including apoptosis, mitochondrial damage, oxidative stress, DNA damage, inflammation, autophagy, aging, calcium homeostasis, vascular homeostasis, and fibrosis. In addition, this review explores potential ncRNAs-based biomarkers and therapeutic strategies, which may help to convert ncRNAs research into clinical practice in the future for early detection and improvement of cancer therapy-induced cardiotoxicity.https://www.frontiersin.org/articles/10.3389/fcvm.2022.946137/fullnon-coding RNAscancer therapycardiotoxicitybiomarkerstherapeutic strategies |
| spellingShingle | Wanli Sun Juping Xu Li Wang Yuchen Jiang Jingrun Cui Xin Su Fan Yang Li Tian Zeyu Si Yanwei Xing Non-coding RNAs in cancer therapy-induced cardiotoxicity: Mechanisms, biomarkers, and treatments Frontiers in Cardiovascular Medicine non-coding RNAs cancer therapy cardiotoxicity biomarkers therapeutic strategies |
| title | Non-coding RNAs in cancer therapy-induced cardiotoxicity: Mechanisms, biomarkers, and treatments |
| title_full | Non-coding RNAs in cancer therapy-induced cardiotoxicity: Mechanisms, biomarkers, and treatments |
| title_fullStr | Non-coding RNAs in cancer therapy-induced cardiotoxicity: Mechanisms, biomarkers, and treatments |
| title_full_unstemmed | Non-coding RNAs in cancer therapy-induced cardiotoxicity: Mechanisms, biomarkers, and treatments |
| title_short | Non-coding RNAs in cancer therapy-induced cardiotoxicity: Mechanisms, biomarkers, and treatments |
| title_sort | non coding rnas in cancer therapy induced cardiotoxicity mechanisms biomarkers and treatments |
| topic | non-coding RNAs cancer therapy cardiotoxicity biomarkers therapeutic strategies |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.946137/full |
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