The extrafollicular response is sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus

The extrafollicular response is sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus

IntroductionMany autoimmune diseases are characterized by germinal center (GC)-derived, affinity-matured, class-switched autoantibodies, and strategies to block GC formation and progression are currently being explored clinically. However, extrafollicular responses can also play a role. The aim of t...

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Bibliographic Details
Main Authors: Lasse F. Voss, Amanda J. Howarth, Thomas R. Wittenborn, Sandra Hummelgaard, Kristian Juul-Madsen, Kristian S. Kastberg, Mathias K. Pedersen, Lisbeth Jensen, Anastasios D. Papanastasiou, Thomas Vorup-Jensen, Kathrin Weyer, Søren E. Degn
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
autoimmunity
B cells
germinal centers
extrafollicular responses
autoantibodies
systemic lupus erythematosus
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1021370/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1021370/full

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