Adolescents with a concussion have altered brain network functional connectivity one month following injury when compared to adolescents with orthopedic injuries
Concussion is a mild traumatic brain injury (mTBI) with increasing prevalence among children and adolescents. Functional connectivity (FC) within and between the default mode network (DMN), central executive network (CEN) and salience network (SN) has been shown to be altered post-concussion. Few st...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158222002765 |
| _version_ | 1797997966250737664 |
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| author | Katherine Healey Zhuo Fang Andra Smith Roger Zemek Andrée-Anne Ledoux |
| author_facet | Katherine Healey Zhuo Fang Andra Smith Roger Zemek Andrée-Anne Ledoux |
| author_sort | Katherine Healey |
| collection | DOAJ |
| description | Concussion is a mild traumatic brain injury (mTBI) with increasing prevalence among children and adolescents. Functional connectivity (FC) within and between the default mode network (DMN), central executive network (CEN) and salience network (SN) has been shown to be altered post-concussion. Few studies have investigated connectivity within and between these 3 networks following a pediatric concussion. The present study explored whether within and between-network FC differs between a pediatric concussion and orthopedic injury (OI) group aged 10–18. Participants underwent a resting-state functional magnetic resonance imaging (rs-fMRI) scan at 4 weeks post-injury. One-way ANCOVA analyses were conducted between groups with the seed-based FC of the 3 networks. A total of 55 concussion and 27 OI participants were included in the analyses. Increased within-network FC of the CEN and decreased between-network FC of the DMN-CEN was found in the concussion group when compared to the OI group. Secondary analyses using spherical SN regions of interest revealed increased within-network FC of the SN and increased between-network FC of the DMN-SN and CEN-SN in the concussion group when compared to the OI group. This study identified differential connectivity patterns following a pediatric concussion as compared to an OI 4 weeks post-injury. These differences indicate potential adaptive brain mechanisms that may provide insight into recovery trajectories and appropriate timing of treatment within the first month following a concussion. |
| first_indexed | 2024-04-11T10:40:59Z |
| format | Article |
| id | doaj.art-46d9210a66be48708cc88a44a8b06afb |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-11T10:40:59Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-46d9210a66be48708cc88a44a8b06afb2022-12-22T04:29:11ZengElsevierNeuroImage: Clinical2213-15822022-01-0136103211Adolescents with a concussion have altered brain network functional connectivity one month following injury when compared to adolescents with orthopedic injuriesKatherine Healey0Zhuo Fang1Andra Smith2Roger Zemek3Andrée-Anne Ledoux4Children’s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada; Department of Neuroscience, Carleton University, Ottawa, Ontario, CanadaSchool of Psychology, University of Ottawa, Ottawa, Ontario, CanadaSchool of Psychology, University of Ottawa, Ottawa, Ontario, CanadaChildren’s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada; Department of Pediatrics, Division of Emergency Medicine, Children’s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, CanadaChildren’s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada; School of Psychology, University of Ottawa, Ottawa, Ontario, Canada; Department of Cellular Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada; Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada; Corresponding author.Concussion is a mild traumatic brain injury (mTBI) with increasing prevalence among children and adolescents. Functional connectivity (FC) within and between the default mode network (DMN), central executive network (CEN) and salience network (SN) has been shown to be altered post-concussion. Few studies have investigated connectivity within and between these 3 networks following a pediatric concussion. The present study explored whether within and between-network FC differs between a pediatric concussion and orthopedic injury (OI) group aged 10–18. Participants underwent a resting-state functional magnetic resonance imaging (rs-fMRI) scan at 4 weeks post-injury. One-way ANCOVA analyses were conducted between groups with the seed-based FC of the 3 networks. A total of 55 concussion and 27 OI participants were included in the analyses. Increased within-network FC of the CEN and decreased between-network FC of the DMN-CEN was found in the concussion group when compared to the OI group. Secondary analyses using spherical SN regions of interest revealed increased within-network FC of the SN and increased between-network FC of the DMN-SN and CEN-SN in the concussion group when compared to the OI group. This study identified differential connectivity patterns following a pediatric concussion as compared to an OI 4 weeks post-injury. These differences indicate potential adaptive brain mechanisms that may provide insight into recovery trajectories and appropriate timing of treatment within the first month following a concussion.http://www.sciencedirect.com/science/article/pii/S2213158222002765Pediatric concussionResting-state functional magnetic resonance imagingFunctional connectivityDefault mode networkSalience networkCentral executive network |
| spellingShingle | Katherine Healey Zhuo Fang Andra Smith Roger Zemek Andrée-Anne Ledoux Adolescents with a concussion have altered brain network functional connectivity one month following injury when compared to adolescents with orthopedic injuries NeuroImage: Clinical Pediatric concussion Resting-state functional magnetic resonance imaging Functional connectivity Default mode network Salience network Central executive network |
| title | Adolescents with a concussion have altered brain network functional connectivity one month following injury when compared to adolescents with orthopedic injuries |
| title_full | Adolescents with a concussion have altered brain network functional connectivity one month following injury when compared to adolescents with orthopedic injuries |
| title_fullStr | Adolescents with a concussion have altered brain network functional connectivity one month following injury when compared to adolescents with orthopedic injuries |
| title_full_unstemmed | Adolescents with a concussion have altered brain network functional connectivity one month following injury when compared to adolescents with orthopedic injuries |
| title_short | Adolescents with a concussion have altered brain network functional connectivity one month following injury when compared to adolescents with orthopedic injuries |
| title_sort | adolescents with a concussion have altered brain network functional connectivity one month following injury when compared to adolescents with orthopedic injuries |
| topic | Pediatric concussion Resting-state functional magnetic resonance imaging Functional connectivity Default mode network Salience network Central executive network |
| url | http://www.sciencedirect.com/science/article/pii/S2213158222002765 |
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