P19 EFFECT OF GROWTH HORMONE REPLACEMENT IN THE VASCULAR SYSTEM OF ADULT PATIENTS WITH CHILDHOOD ONSET HYPOPITUITARISM
Objective: To evaluate the human recombinant growth hormone replacement (hrGHr) in the metabolic parameters and vascular system in adult patients with childhood onset hypopituitarism (COH). Patients and methods: Fifty-one adult with COH were selected for the study. They were divided into 2 groups:...
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| Format: | Article |
| Language: | English |
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BMC
2018-12-01
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| Series: | Artery Research |
| Online Access: | https://www.atlantis-press.com/article/125930020/view |
| _version_ | 1818539151146876928 |
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| author | Isabela Biscotto Valeria Costa-Hong Luiz Bortolotto Luciani Carvalho |
| author_facet | Isabela Biscotto Valeria Costa-Hong Luiz Bortolotto Luciani Carvalho |
| author_sort | Isabela Biscotto |
| collection | DOAJ |
| description | Objective: To evaluate the human recombinant growth hormone replacement (hrGHr) in the metabolic parameters and vascular system in adult patients with childhood onset hypopituitarism (COH).
Patients and methods: Fifty-one adult with COH were selected for the study. They were divided into 2 groups: 1- hrGHr: 13 male, 14 female with median age 33.2 yrs, rhGHr in adult life with 7.38 yrs median time; 2 - Without hrGHr: 13 male, 11 female with 36.9 yrs median age and without hrGHr in adult life of 10.4 yrs median time. Anthropometric parameters, dual-energy X-ray absorptiometry (DEXA), lipid and glycemic profile, and structural and functional parameters of the arterial vessels (carotid intima media thickness, arterial stiffness and flow mediated dilation) were evaluated.
Results: The diagnosis of obesity and overweight was higher in patients without hrGHr. Among the anthropometric characteristics, the waist-to-height ratio and diastolic blood pressure were higher in patients without replacement (p = 0.03 and p = 0.019, respectively). In the evaluation of body composition through DEXA, the Fat Mass Index among patients under hrGHr was significantly lower than in patients without hrGHr (p = 0.029). Although no statistical difference in the vascular parameters between patients with and without hrGHr, it was observed a trend towards a higher arterial stiffness in the group without replacement (p = 0.051). In the group of patients without hrGHr, arterial stiffness had a significant and positive correlation with the time without hrGHr (p = 0.038).
Conclusions: These data suggest that the hrGHr in adults with COH may have protective effects on cardiovascular system. |
| first_indexed | 2024-12-11T21:38:16Z |
| format | Article |
| id | doaj.art-46da9671931b4642b79c1ae454fc609c |
| institution | Directory Open Access Journal |
| issn | 1876-4401 |
| language | English |
| last_indexed | 2024-12-11T21:38:16Z |
| publishDate | 2018-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Artery Research |
| spelling | doaj.art-46da9671931b4642b79c1ae454fc609c2022-12-22T00:49:55ZengBMCArtery Research1876-44012018-12-012410.1016/j.artres.2018.10.072P19 EFFECT OF GROWTH HORMONE REPLACEMENT IN THE VASCULAR SYSTEM OF ADULT PATIENTS WITH CHILDHOOD ONSET HYPOPITUITARISMIsabela BiscottoValeria Costa-HongLuiz BortolottoLuciani CarvalhoObjective: To evaluate the human recombinant growth hormone replacement (hrGHr) in the metabolic parameters and vascular system in adult patients with childhood onset hypopituitarism (COH). Patients and methods: Fifty-one adult with COH were selected for the study. They were divided into 2 groups: 1- hrGHr: 13 male, 14 female with median age 33.2 yrs, rhGHr in adult life with 7.38 yrs median time; 2 - Without hrGHr: 13 male, 11 female with 36.9 yrs median age and without hrGHr in adult life of 10.4 yrs median time. Anthropometric parameters, dual-energy X-ray absorptiometry (DEXA), lipid and glycemic profile, and structural and functional parameters of the arterial vessels (carotid intima media thickness, arterial stiffness and flow mediated dilation) were evaluated. Results: The diagnosis of obesity and overweight was higher in patients without hrGHr. Among the anthropometric characteristics, the waist-to-height ratio and diastolic blood pressure were higher in patients without replacement (p = 0.03 and p = 0.019, respectively). In the evaluation of body composition through DEXA, the Fat Mass Index among patients under hrGHr was significantly lower than in patients without hrGHr (p = 0.029). Although no statistical difference in the vascular parameters between patients with and without hrGHr, it was observed a trend towards a higher arterial stiffness in the group without replacement (p = 0.051). In the group of patients without hrGHr, arterial stiffness had a significant and positive correlation with the time without hrGHr (p = 0.038). Conclusions: These data suggest that the hrGHr in adults with COH may have protective effects on cardiovascular system.https://www.atlantis-press.com/article/125930020/view |
| spellingShingle | Isabela Biscotto Valeria Costa-Hong Luiz Bortolotto Luciani Carvalho P19 EFFECT OF GROWTH HORMONE REPLACEMENT IN THE VASCULAR SYSTEM OF ADULT PATIENTS WITH CHILDHOOD ONSET HYPOPITUITARISM Artery Research |
| title | P19 EFFECT OF GROWTH HORMONE REPLACEMENT IN THE VASCULAR SYSTEM OF ADULT PATIENTS WITH CHILDHOOD ONSET HYPOPITUITARISM |
| title_full | P19 EFFECT OF GROWTH HORMONE REPLACEMENT IN THE VASCULAR SYSTEM OF ADULT PATIENTS WITH CHILDHOOD ONSET HYPOPITUITARISM |
| title_fullStr | P19 EFFECT OF GROWTH HORMONE REPLACEMENT IN THE VASCULAR SYSTEM OF ADULT PATIENTS WITH CHILDHOOD ONSET HYPOPITUITARISM |
| title_full_unstemmed | P19 EFFECT OF GROWTH HORMONE REPLACEMENT IN THE VASCULAR SYSTEM OF ADULT PATIENTS WITH CHILDHOOD ONSET HYPOPITUITARISM |
| title_short | P19 EFFECT OF GROWTH HORMONE REPLACEMENT IN THE VASCULAR SYSTEM OF ADULT PATIENTS WITH CHILDHOOD ONSET HYPOPITUITARISM |
| title_sort | p19 effect of growth hormone replacement in the vascular system of adult patients with childhood onset hypopituitarism |
| url | https://www.atlantis-press.com/article/125930020/view |
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