Polygenic risk score for ulcerative colitis predicts immune checkpoint inhibitor-mediated colitis

Polygenic risk score for ulcerative colitis predicts immune checkpoint inhibitor-mediated colitis

Abstract Immune checkpoint inhibitor-mediated colitis (IMC) is a common adverse event of treatment with immune checkpoint inhibitors (ICI). We hypothesize that genetic susceptibility to Crohn’s disease (CD) and ulcerative colitis (UC) predisposes to IMC. In this study, we first develop a polygenic r...

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Bibliographische Detailangaben
Hauptverfasser: Pooja Middha, Rohit Thummalapalli, Michael J. Betti, Lydia Yao, Zoe Quandt, Karmugi Balaratnam, Cosmin A. Bejan, Eduardo Cardenas, Christina J. Falcon, David M. Faleck, Princess Margaret Lung Group, Matthew A. Gubens, Scott Huntsman, Douglas B. Johnson, Linda Kachuri, Khaleeq Khan, Min Li, Christine M. Lovly, Megan H. Murray, Devalben Patel, Kristin Werking, Yaomin Xu, Luna Jia Zhan, Justin M. Balko, Geoffrey Liu, Melinda C. Aldrich, Adam J. Schoenfeld, Elad Ziv
Format: Artikel
Sprache:English
Veröffentlicht: Nature Portfolio 2024-03-01
Schriftenreihe:Nature Communications
Online Zugang:https://doi.org/10.1038/s41467-023-44512-4

Online

https://doi.org/10.1038/s41467-023-44512-4

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