Cortical ChAT+ neurons co-transmit acetylcholine and GABA in a target- and brain-region-specific manner

Cortical ChAT+ neurons co-transmit acetylcholine and GABA in a target- and brain-region-specific manner

The mouse cerebral cortex contains neurons that express choline acetyltransferase (ChAT) and are a potential local source of acetylcholine. However, the neurotransmitters released by cortical ChAT+ neurons and their synaptic connectivity are unknown. We show that the nearly all cortical ChAT+ neuron...

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Bibliographic Details
Main Authors: Adam J Granger, Wengang Wang, Keiramarie Robertson, Mahmoud El-Rifai, Andrea F Zanello, Karina Bistrong, Arpiar Saunders, Brian W Chow, Vicente Nuñez, Miguel Turrero García, Corey C Harwell, Chenghua Gu, Bernardo L Sabatini
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-07-01
Series:eLife
Subjects:
neuromodulation
neurotransmitter co-release
Acetylcholine
GABA
VIP
cortical interneurons
Online Access:https://elifesciences.org/articles/57749

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