Early life environmental antibiotic exposure and preschool allergic diseases: A biomonitoring-based prospective study in eastern China
BackgroundGlobally, the prevalence of allergic diseases remains high, as does the level of environmental antibiotics. It has been found that clinical antibiotic application may increase preschool allergy risk. However, few biomonitoring studies have been conducted about the association between early...
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| Format: | Article |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.1043942/full |
| _version_ | 1797991541595176960 |
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| author | Hang Zheng Hang Zheng Hang Zheng Hang Zheng Xinxin Zeng Xinxin Zeng Xinxin Zeng Xinxin Zeng Qiuling Xie Yuhang Wu Quanhua Liu Qian Chen Lisu Huang Lisu Huang Lisu Huang Weixi Zhang |
| author_facet | Hang Zheng Hang Zheng Hang Zheng Hang Zheng Xinxin Zeng Xinxin Zeng Xinxin Zeng Xinxin Zeng Qiuling Xie Yuhang Wu Quanhua Liu Qian Chen Lisu Huang Lisu Huang Lisu Huang Weixi Zhang |
| author_sort | Hang Zheng |
| collection | DOAJ |
| description | BackgroundGlobally, the prevalence of allergic diseases remains high, as does the level of environmental antibiotics. It has been found that clinical antibiotic application may increase preschool allergy risk. However, few biomonitoring studies have been conducted about the association between early life environmental trace dose antibiotic exposure and preschool allergy.ObjectiveTo analyze the association between prenatal environmental antibiotic levels and allergic diseases using logistic regression models.MethodsA total of 743 pregnant women and their offspring from the Shanghai Allergy Birth Cohort completed five years follow-up, and 251 mother-infant pairs were finally included. Maternal urine samples were collected for 15 antibiotic quantitative measurements using liquid chromatography-tandem mass spectrometry. The high-antibiotic group was defined as having at least half of antibiotics exceeding the median concentration. Allergic diseases were assessed by clinicians through clinical history, standardized questionnaires, and annual physical examinations until the age of five. Skin-prick-test (SPT) was performed at 5 years old.ResultsThe incidence of allergic diseases was generally higher in the high-antibiotic than that in the low-antibiotic group. Compared to the low-comprehensive antibiotic group, children in the high-antibiotic group were weakly associated with allergic diseases but had a 6-fold increased risk of food allergens sensitivity (OR: 7.09, 95% CI: 1.59, 31.74). Association of above-median single prenatal antibiotic concentration exposure and allergic diseases was also observed (azithromycin and asthma, OR: 2.72, 95% CI: 1.15, 6.42; enrofloxacin and wheeze, OR: 2.22, 95% CI: 1.22, 4.05; trimethoprim and atopic dermatitis, OR: 2.00, 95% CI: 1.08, 3.71). Moreover, children with higher prenatal norfloxacin levels were more sensitive to food allergens (OR: 5.52, 95%CI: 1.54, 19.71).ConclusionEarly-life environmental antibiotic exposure may be correlated with an increased risk of asthma, wheeze, atopic dermatitis, and SPT positivity for food allergens in 5-year-old children. |
| first_indexed | 2024-04-11T08:53:43Z |
| format | Article |
| id | doaj.art-46e1164110434444866e21863b6a8ed7 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-11T08:53:43Z |
| publishDate | 2022-10-01 |
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| series | Frontiers in Public Health |
| spelling | doaj.art-46e1164110434444866e21863b6a8ed72022-12-22T04:33:21ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-10-011010.3389/fpubh.2022.10439421043942Early life environmental antibiotic exposure and preschool allergic diseases: A biomonitoring-based prospective study in eastern ChinaHang Zheng0Hang Zheng1Hang Zheng2Hang Zheng3Xinxin Zeng4Xinxin Zeng5Xinxin Zeng6Xinxin Zeng7Qiuling Xie8Yuhang Wu9Quanhua Liu10Qian Chen11Lisu Huang12Lisu Huang13Lisu Huang14Weixi Zhang15Department of Pediatric Allergy and Immunology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Infectious Diseases, Xinhua Children's Hospital, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Infectious Diseases, the Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaDepartment of Pediatric Allergy and Immunology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Infectious Diseases, Xinhua Children's Hospital, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Infectious Diseases, the Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaDepartment of Infectious Diseases, Xinhua Children's Hospital, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Infectious Diseases, Xinhua Children's Hospital, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Pediatric Respiratory Diseases, Xinhua Children's Hospital, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Infectious Diseases, Xinhua Children's Hospital, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Infectious Diseases, the Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaDepartment of Pediatric Allergy and Immunology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, ChinaBackgroundGlobally, the prevalence of allergic diseases remains high, as does the level of environmental antibiotics. It has been found that clinical antibiotic application may increase preschool allergy risk. However, few biomonitoring studies have been conducted about the association between early life environmental trace dose antibiotic exposure and preschool allergy.ObjectiveTo analyze the association between prenatal environmental antibiotic levels and allergic diseases using logistic regression models.MethodsA total of 743 pregnant women and their offspring from the Shanghai Allergy Birth Cohort completed five years follow-up, and 251 mother-infant pairs were finally included. Maternal urine samples were collected for 15 antibiotic quantitative measurements using liquid chromatography-tandem mass spectrometry. The high-antibiotic group was defined as having at least half of antibiotics exceeding the median concentration. Allergic diseases were assessed by clinicians through clinical history, standardized questionnaires, and annual physical examinations until the age of five. Skin-prick-test (SPT) was performed at 5 years old.ResultsThe incidence of allergic diseases was generally higher in the high-antibiotic than that in the low-antibiotic group. Compared to the low-comprehensive antibiotic group, children in the high-antibiotic group were weakly associated with allergic diseases but had a 6-fold increased risk of food allergens sensitivity (OR: 7.09, 95% CI: 1.59, 31.74). Association of above-median single prenatal antibiotic concentration exposure and allergic diseases was also observed (azithromycin and asthma, OR: 2.72, 95% CI: 1.15, 6.42; enrofloxacin and wheeze, OR: 2.22, 95% CI: 1.22, 4.05; trimethoprim and atopic dermatitis, OR: 2.00, 95% CI: 1.08, 3.71). Moreover, children with higher prenatal norfloxacin levels were more sensitive to food allergens (OR: 5.52, 95%CI: 1.54, 19.71).ConclusionEarly-life environmental antibiotic exposure may be correlated with an increased risk of asthma, wheeze, atopic dermatitis, and SPT positivity for food allergens in 5-year-old children.https://www.frontiersin.org/articles/10.3389/fpubh.2022.1043942/fullallergyasthmaenvironmental antibioticenrofloxacinazithromycinskin-prick-test |
| spellingShingle | Hang Zheng Hang Zheng Hang Zheng Hang Zheng Xinxin Zeng Xinxin Zeng Xinxin Zeng Xinxin Zeng Qiuling Xie Yuhang Wu Quanhua Liu Qian Chen Lisu Huang Lisu Huang Lisu Huang Weixi Zhang Early life environmental antibiotic exposure and preschool allergic diseases: A biomonitoring-based prospective study in eastern China Frontiers in Public Health allergy asthma environmental antibiotic enrofloxacin azithromycin skin-prick-test |
| title | Early life environmental antibiotic exposure and preschool allergic diseases: A biomonitoring-based prospective study in eastern China |
| title_full | Early life environmental antibiotic exposure and preschool allergic diseases: A biomonitoring-based prospective study in eastern China |
| title_fullStr | Early life environmental antibiotic exposure and preschool allergic diseases: A biomonitoring-based prospective study in eastern China |
| title_full_unstemmed | Early life environmental antibiotic exposure and preschool allergic diseases: A biomonitoring-based prospective study in eastern China |
| title_short | Early life environmental antibiotic exposure and preschool allergic diseases: A biomonitoring-based prospective study in eastern China |
| title_sort | early life environmental antibiotic exposure and preschool allergic diseases a biomonitoring based prospective study in eastern china |
| topic | allergy asthma environmental antibiotic enrofloxacin azithromycin skin-prick-test |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.1043942/full |
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