Low body mass index is associated with diminished plasma cytokines and chemokines in both active and latent tuberculosis
IntroductionLow body mass index (BMI) is a major risk factor for tuberculosis (PTB). Low BMI can impair the immune system and thus might affect TB incidence.MethodsWe examined the plasma levels of Type 1, Type 17, pro-inflammatory, Type 2 and regulatory cytokines and CC and CXC chemokines in PTB and...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1194682/full |
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| author | Nathella Pavan Kumar Arul P. Nancy Kadar Moideen Pradeep A. Menon Vaithilingam V. Banurekha Dina Nair Sujatha Nott Subash Babu Subash Babu |
| author_facet | Nathella Pavan Kumar Arul P. Nancy Kadar Moideen Pradeep A. Menon Vaithilingam V. Banurekha Dina Nair Sujatha Nott Subash Babu Subash Babu |
| author_sort | Nathella Pavan Kumar |
| collection | DOAJ |
| description | IntroductionLow body mass index (BMI) is a major risk factor for tuberculosis (PTB). Low BMI can impair the immune system and thus might affect TB incidence.MethodsWe examined the plasma levels of Type 1, Type 17, pro-inflammatory, Type 2 and regulatory cytokines and CC and CXC chemokines in PTB and latent TB (LTB) individuals with low BMI (LBMI) or normal BMI (NBMI).ResultsOur data show that PTB is associated with significantly lower levels of IFNγ, TNFα, IL-2, IL-17A, IL-6, IL-12, IL-4 and IL-5 cytokines but significantly higher levels of IL-10, TGFβ and GM-CSF in LBMI compared to NBMI. Similarly, PTB is also associated with significantly lower levels of CCL2, CCL3, CCL11, CXCL1, CXCL9 and CXCL10 chemokines in LBMI compared to NBMI. Our data reveals that LTB is associated with significantly lower levels of IFNγ, TNFα, IL-2, IL1β, IL-12, IL-13 cytokines but significantly higher levels of IL-10, TGFβ, IL-4 and IL-22 in LBMI compared to NBMI. Similarly, LTB is also associated with significantly lower levels of CCL2, CXCL1, CXCL9 and CXCL10 and significantly higher levels of CCL1, CCL3, and CCL4 in LBMI compared to NBMI.ConclusionThus, LBMI has a major impact on the cytokine and chemokine milieu of both PTB and LTB and might predispose to the increased risk of tuberculosis by this immunomodulatory effect. |
| first_indexed | 2024-03-13T08:19:31Z |
| format | Article |
| id | doaj.art-46e28c56f49f48e394fa45305c6d0855 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-13T08:19:31Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-46e28c56f49f48e394fa45305c6d08552023-05-31T10:23:39ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-05-011010.3389/fnut.2023.11946821194682Low body mass index is associated with diminished plasma cytokines and chemokines in both active and latent tuberculosisNathella Pavan Kumar0Arul P. Nancy1Kadar Moideen2Pradeep A. Menon3Vaithilingam V. Banurekha4Dina Nair5Sujatha Nott6Subash Babu7Subash Babu8ICMR-National Institute for Research in Tuberculosis, Chennai, IndiaNIAID – International Center for Excellence in Research, Chennai, IndiaNIAID – International Center for Excellence in Research, Chennai, IndiaICMR-National Institute for Research in Tuberculosis, Chennai, IndiaICMR-National Institute for Research in Tuberculosis, Chennai, IndiaICMR-National Institute for Research in Tuberculosis, Chennai, IndiaInfectious Diseases, Dignity Health, Chandler, AZ, United StatesNIAID – International Center for Excellence in Research, Chennai, IndiaLPD, NIAID, NIH, Rockville, MD, United StatesIntroductionLow body mass index (BMI) is a major risk factor for tuberculosis (PTB). Low BMI can impair the immune system and thus might affect TB incidence.MethodsWe examined the plasma levels of Type 1, Type 17, pro-inflammatory, Type 2 and regulatory cytokines and CC and CXC chemokines in PTB and latent TB (LTB) individuals with low BMI (LBMI) or normal BMI (NBMI).ResultsOur data show that PTB is associated with significantly lower levels of IFNγ, TNFα, IL-2, IL-17A, IL-6, IL-12, IL-4 and IL-5 cytokines but significantly higher levels of IL-10, TGFβ and GM-CSF in LBMI compared to NBMI. Similarly, PTB is also associated with significantly lower levels of CCL2, CCL3, CCL11, CXCL1, CXCL9 and CXCL10 chemokines in LBMI compared to NBMI. Our data reveals that LTB is associated with significantly lower levels of IFNγ, TNFα, IL-2, IL1β, IL-12, IL-13 cytokines but significantly higher levels of IL-10, TGFβ, IL-4 and IL-22 in LBMI compared to NBMI. Similarly, LTB is also associated with significantly lower levels of CCL2, CXCL1, CXCL9 and CXCL10 and significantly higher levels of CCL1, CCL3, and CCL4 in LBMI compared to NBMI.ConclusionThus, LBMI has a major impact on the cytokine and chemokine milieu of both PTB and LTB and might predispose to the increased risk of tuberculosis by this immunomodulatory effect.https://www.frontiersin.org/articles/10.3389/fnut.2023.1194682/fulltuberculosisbody mass indexcytokineschemokineslatent tuberculosis |
| spellingShingle | Nathella Pavan Kumar Arul P. Nancy Kadar Moideen Pradeep A. Menon Vaithilingam V. Banurekha Dina Nair Sujatha Nott Subash Babu Subash Babu Low body mass index is associated with diminished plasma cytokines and chemokines in both active and latent tuberculosis Frontiers in Nutrition tuberculosis body mass index cytokines chemokines latent tuberculosis |
| title | Low body mass index is associated with diminished plasma cytokines and chemokines in both active and latent tuberculosis |
| title_full | Low body mass index is associated with diminished plasma cytokines and chemokines in both active and latent tuberculosis |
| title_fullStr | Low body mass index is associated with diminished plasma cytokines and chemokines in both active and latent tuberculosis |
| title_full_unstemmed | Low body mass index is associated with diminished plasma cytokines and chemokines in both active and latent tuberculosis |
| title_short | Low body mass index is associated with diminished plasma cytokines and chemokines in both active and latent tuberculosis |
| title_sort | low body mass index is associated with diminished plasma cytokines and chemokines in both active and latent tuberculosis |
| topic | tuberculosis body mass index cytokines chemokines latent tuberculosis |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1194682/full |
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