Clinical Impact of <sup>18</sup>F-FDG PET/CT in the Diagnostic Workup of Pancreatic Ductal Adenocarcinoma: A Systematic Review
In this review, the performance of fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) in the diagnostic workup of pancreatic ductal adenocarcinoma (PDAC) is evaluated. A comprehensive literature search up to September 2020 was performed, selecting studies with the p...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/10/12/1042 |
| _version_ | 1797545884026667008 |
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| author | Annachiara Arnone Riccardo Laudicella Federico Caobelli Priscilla Guglielmo Marianna Spallino Elisabetta Abenavoli Anna Lisa Martini Rossella Filice Alessio Danilo Comis Marco Cuzzocrea Flavia Linguanti Laura Evangelista Pierpaolo Alongi |
| author_facet | Annachiara Arnone Riccardo Laudicella Federico Caobelli Priscilla Guglielmo Marianna Spallino Elisabetta Abenavoli Anna Lisa Martini Rossella Filice Alessio Danilo Comis Marco Cuzzocrea Flavia Linguanti Laura Evangelista Pierpaolo Alongi |
| author_sort | Annachiara Arnone |
| collection | DOAJ |
| description | In this review, the performance of fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) in the diagnostic workup of pancreatic ductal adenocarcinoma (PDAC) is evaluated. A comprehensive literature search up to September 2020 was performed, selecting studies with the presence of: sample size ≥10 patients and index test (i.e., “FDG” or “18F-FDG” AND “pancreatic adenocarcinoma” or “pancreas cancer” AND “PET” or “positron emission tomography”). The methodological quality was evaluated using the revised quality assessment of diagnostic accuracy studies (QUADAS-2) tool and presented according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. Basic data (authors, year of publication, country and study design), patients’ characteristics (number of enrolled subjects and age), disease phase, type of treatment and grading were retrieved. Forty-six articles met the adopted research criteria. The articles were divided according to the considered clinical context. Namely, besides conventional anatomical imaging, such as computed tomography (CT) and magnetic resonance imaging (MRI), molecular imaging with FDG PET/CT is an important tool in PDAC, for all disease stages. Further prospective studies will be necessary to confirm the cost-effectiveness of such imaging techniques by testing its real potential improvement in the clinical management of PDAC. |
| first_indexed | 2024-03-10T14:21:15Z |
| format | Article |
| id | doaj.art-46e2eeea1ff3432ab69441c7f946d3da |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T14:21:15Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-46e2eeea1ff3432ab69441c7f946d3da2023-11-20T23:20:13ZengMDPI AGDiagnostics2075-44182020-12-011012104210.3390/diagnostics10121042Clinical Impact of <sup>18</sup>F-FDG PET/CT in the Diagnostic Workup of Pancreatic Ductal Adenocarcinoma: A Systematic ReviewAnnachiara Arnone0Riccardo Laudicella1Federico Caobelli2Priscilla Guglielmo3Marianna Spallino4Elisabetta Abenavoli5Anna Lisa Martini6Rossella Filice7Alessio Danilo Comis8Marco Cuzzocrea9Flavia Linguanti10Laura Evangelista11Pierpaolo Alongi12Nuclear Medicine Unit, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, 50134 Florence, ItalyDepartment of Biomedical and Dental Sciences and of Morpho-Functional Imaging, Nuclear Medicine Unit, University of Messina, 98125 Messina, ItalyClinic of Radiology & Nuclear Medicine, University Hospital Basel, University of Basel, 4031 Basel, SwitzerlandNuclear Medicine Division, University Hospital of Parma, 43126 Parma, ItalyNuclear Medicine Unit, ASST “Papa Giovanni XXIII”, 24127 Bergamo, ItalyNuclear Medicine Unit, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, 50134 Florence, ItalyNuclear Medicine Unit, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, 50134 Florence, ItalyDepartment of Biomedical and Dental Sciences and of Morpho-Functional Imaging, Nuclear Medicine Unit, University of Messina, 98125 Messina, ItalyDepartment of Biomedical and Dental Sciences and of Morpho-Functional Imaging, Nuclear Medicine Unit, University of Messina, 98125 Messina, ItalyNuclear Medicine, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyNuclear Medicine Unit, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, 50134 Florence, ItalyNuclear Medicine Unit, Department of Medicine, Padova University Hospital, Via Giustiniani 2, 35128 Padova, ItalyUnit of Nuclear Medicine, Fondazione Istituto G.Giglio, 90015 Cefalù, ItalyIn this review, the performance of fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) in the diagnostic workup of pancreatic ductal adenocarcinoma (PDAC) is evaluated. A comprehensive literature search up to September 2020 was performed, selecting studies with the presence of: sample size ≥10 patients and index test (i.e., “FDG” or “18F-FDG” AND “pancreatic adenocarcinoma” or “pancreas cancer” AND “PET” or “positron emission tomography”). The methodological quality was evaluated using the revised quality assessment of diagnostic accuracy studies (QUADAS-2) tool and presented according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. Basic data (authors, year of publication, country and study design), patients’ characteristics (number of enrolled subjects and age), disease phase, type of treatment and grading were retrieved. Forty-six articles met the adopted research criteria. The articles were divided according to the considered clinical context. Namely, besides conventional anatomical imaging, such as computed tomography (CT) and magnetic resonance imaging (MRI), molecular imaging with FDG PET/CT is an important tool in PDAC, for all disease stages. Further prospective studies will be necessary to confirm the cost-effectiveness of such imaging techniques by testing its real potential improvement in the clinical management of PDAC.https://www.mdpi.com/2075-4418/10/12/1042pancreaspositron emission tomographyPET/CTpancreatic ductal adenocarcinomaFDG |
| spellingShingle | Annachiara Arnone Riccardo Laudicella Federico Caobelli Priscilla Guglielmo Marianna Spallino Elisabetta Abenavoli Anna Lisa Martini Rossella Filice Alessio Danilo Comis Marco Cuzzocrea Flavia Linguanti Laura Evangelista Pierpaolo Alongi Clinical Impact of <sup>18</sup>F-FDG PET/CT in the Diagnostic Workup of Pancreatic Ductal Adenocarcinoma: A Systematic Review Diagnostics pancreas positron emission tomography PET/CT pancreatic ductal adenocarcinoma FDG |
| title | Clinical Impact of <sup>18</sup>F-FDG PET/CT in the Diagnostic Workup of Pancreatic Ductal Adenocarcinoma: A Systematic Review |
| title_full | Clinical Impact of <sup>18</sup>F-FDG PET/CT in the Diagnostic Workup of Pancreatic Ductal Adenocarcinoma: A Systematic Review |
| title_fullStr | Clinical Impact of <sup>18</sup>F-FDG PET/CT in the Diagnostic Workup of Pancreatic Ductal Adenocarcinoma: A Systematic Review |
| title_full_unstemmed | Clinical Impact of <sup>18</sup>F-FDG PET/CT in the Diagnostic Workup of Pancreatic Ductal Adenocarcinoma: A Systematic Review |
| title_short | Clinical Impact of <sup>18</sup>F-FDG PET/CT in the Diagnostic Workup of Pancreatic Ductal Adenocarcinoma: A Systematic Review |
| title_sort | clinical impact of sup 18 sup f fdg pet ct in the diagnostic workup of pancreatic ductal adenocarcinoma a systematic review |
| topic | pancreas positron emission tomography PET/CT pancreatic ductal adenocarcinoma FDG |
| url | https://www.mdpi.com/2075-4418/10/12/1042 |
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