Impact of the COVID-19 pandemic on the incidence and type of infections in hospitalized patients with cirrhosis: a retrospective study
Abstract Infections are a major cause of morbidity and mortality in cirrhosis, especially those caused by multi-drug resistant bacteria. During the COVID-19 pandemic, the incidence and type of infection in these patients may have been influenced by the restrictive measures implemented. We aimed to c...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-52452-2 |
| _version_ | 1797275065371328512 |
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| author | Berta Cuyàs Anna Huerta Maria Poca Edilmar Alvarado-Tapias Anna Brujats Eva Román Carlos Guarner Àngels Escorsell German Soriano |
| author_facet | Berta Cuyàs Anna Huerta Maria Poca Edilmar Alvarado-Tapias Anna Brujats Eva Román Carlos Guarner Àngels Escorsell German Soriano |
| author_sort | Berta Cuyàs |
| collection | DOAJ |
| description | Abstract Infections are a major cause of morbidity and mortality in cirrhosis, especially those caused by multi-drug resistant bacteria. During the COVID-19 pandemic, the incidence and type of infection in these patients may have been influenced by the restrictive measures implemented. We aimed to compare the infections in patients with cirrhosis hospitalized before the COVID-19 pandemic versus those hospitalized during the pandemic. We retrospectively compared infections in patients with cirrhosis hospitalized in the hepatology unit during the pre-pandemic period (3/2019–2/2020) with infections in patients hospitalized during the pandemic (3/2020–2/2021). Baseline characteristics, type of infections, type of bacteria, antimicrobial resistance and mortality were evaluated. There were 251 hospitalizations in 170 patients during the pre-pandemic period and 169 hospitalizations in 114 patients during the pandemic period. One or more infections were identified in 40.6% of hospitalizations during the pre-pandemic period and 43.8% of hospitalizations during the pandemic, P = 0.52. We found 131 infections in the pre-pandemic period and 75 infections during the pandemic. The percentage of nosocomial infections decreased in the pandemic period (25.3% vs. 37.4% in the pre-pandemic period, P = 0.06). We found a non-significant trend to a higher incidence of infections by multi-drug resistant organisms (MDRO) in the pandemic period than in the pre-pandemic period (6.5% vs. 4%). The incidence of infections was similar in both periods. However, during the pandemic, we observed a trend to a lower incidence of nosocomial infections with a higher incidence of MDRO infections. |
| first_indexed | 2024-03-07T15:08:59Z |
| format | Article |
| id | doaj.art-46e37b3fc33b49b4850a1ffa69006f58 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:08:59Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-46e37b3fc33b49b4850a1ffa69006f582024-03-05T18:45:39ZengNature PortfolioScientific Reports2045-23222024-02-011411810.1038/s41598-024-52452-2Impact of the COVID-19 pandemic on the incidence and type of infections in hospitalized patients with cirrhosis: a retrospective studyBerta Cuyàs0Anna Huerta1Maria Poca2Edilmar Alvarado-Tapias3Anna Brujats4Eva Román5Carlos Guarner6Àngels Escorsell7German Soriano8Department of Gastroenterology, Hospital Santa Creu i Sant Pau, Institut de Recerca Sant PauDepartment of Gastroenterology, Hospital Santa Creu i Sant Pau, Institut de Recerca Sant PauDepartment of Gastroenterology, Hospital Santa Creu i Sant Pau, Institut de Recerca Sant PauDepartment of Gastroenterology, Hospital Santa Creu i Sant Pau, Institut de Recerca Sant PauDepartment of Gastroenterology, Hospital Santa Creu i Sant Pau, Institut de Recerca Sant PauDepartment of Gastroenterology, Hospital Santa Creu i Sant Pau, Institut de Recerca Sant PauDepartment of Gastroenterology, Hospital Santa Creu i Sant Pau, Institut de Recerca Sant PauDepartment of Gastroenterology, Hospital Santa Creu i Sant Pau, Institut de Recerca Sant PauDepartment of Gastroenterology, Hospital Santa Creu i Sant Pau, Institut de Recerca Sant PauAbstract Infections are a major cause of morbidity and mortality in cirrhosis, especially those caused by multi-drug resistant bacteria. During the COVID-19 pandemic, the incidence and type of infection in these patients may have been influenced by the restrictive measures implemented. We aimed to compare the infections in patients with cirrhosis hospitalized before the COVID-19 pandemic versus those hospitalized during the pandemic. We retrospectively compared infections in patients with cirrhosis hospitalized in the hepatology unit during the pre-pandemic period (3/2019–2/2020) with infections in patients hospitalized during the pandemic (3/2020–2/2021). Baseline characteristics, type of infections, type of bacteria, antimicrobial resistance and mortality were evaluated. There were 251 hospitalizations in 170 patients during the pre-pandemic period and 169 hospitalizations in 114 patients during the pandemic period. One or more infections were identified in 40.6% of hospitalizations during the pre-pandemic period and 43.8% of hospitalizations during the pandemic, P = 0.52. We found 131 infections in the pre-pandemic period and 75 infections during the pandemic. The percentage of nosocomial infections decreased in the pandemic period (25.3% vs. 37.4% in the pre-pandemic period, P = 0.06). We found a non-significant trend to a higher incidence of infections by multi-drug resistant organisms (MDRO) in the pandemic period than in the pre-pandemic period (6.5% vs. 4%). The incidence of infections was similar in both periods. However, during the pandemic, we observed a trend to a lower incidence of nosocomial infections with a higher incidence of MDRO infections.https://doi.org/10.1038/s41598-024-52452-2 |
| spellingShingle | Berta Cuyàs Anna Huerta Maria Poca Edilmar Alvarado-Tapias Anna Brujats Eva Román Carlos Guarner Àngels Escorsell German Soriano Impact of the COVID-19 pandemic on the incidence and type of infections in hospitalized patients with cirrhosis: a retrospective study Scientific Reports |
| title | Impact of the COVID-19 pandemic on the incidence and type of infections in hospitalized patients with cirrhosis: a retrospective study |
| title_full | Impact of the COVID-19 pandemic on the incidence and type of infections in hospitalized patients with cirrhosis: a retrospective study |
| title_fullStr | Impact of the COVID-19 pandemic on the incidence and type of infections in hospitalized patients with cirrhosis: a retrospective study |
| title_full_unstemmed | Impact of the COVID-19 pandemic on the incidence and type of infections in hospitalized patients with cirrhosis: a retrospective study |
| title_short | Impact of the COVID-19 pandemic on the incidence and type of infections in hospitalized patients with cirrhosis: a retrospective study |
| title_sort | impact of the covid 19 pandemic on the incidence and type of infections in hospitalized patients with cirrhosis a retrospective study |
| url | https://doi.org/10.1038/s41598-024-52452-2 |
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