Non-alpine primary thyroid angiosarcoma
SUMMARY Thyroid angiosarcoma is an extremely rare malignancy, which occurs more frequently in the alpine region, likely associated with iodine deficiency and endemic goiter. This is an aggressive neoplasm that usually harbors a poor prognosis. We report the case of a 49-year-old Portuguese female pa...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Brazilian Society of Endocrinology and Metabolism
2022-06-01
|
| Series: | Archives of Endocrinology and Metabolism |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972022005006201&tlng=en |
| _version_ | 1811248185718341632 |
|---|---|
| author | Nádia Mourinho Bala Pedro Simões José Maria Aragüés Ricardo Veiga Sílvia Guerra Cristina Valadas |
| author_facet | Nádia Mourinho Bala Pedro Simões José Maria Aragüés Ricardo Veiga Sílvia Guerra Cristina Valadas |
| author_sort | Nádia Mourinho Bala |
| collection | DOAJ |
| description | SUMMARY Thyroid angiosarcoma is an extremely rare malignancy, which occurs more frequently in the alpine region, likely associated with iodine deficiency and endemic goiter. This is an aggressive neoplasm that usually harbors a poor prognosis. We report the case of a 49-year-old Portuguese female patient presenting with a large nodule in the anterior neck region, with rapid growth and associated dysphonia. The neck ultrasound showed a hypoechogenic and heterogeneous thyroid nodule, with a larger axis of 44 mm. The fine needle aspiration cytology was not conclusive, and a biopsy of the lesion was performed. The result was suggestive of a mesenchymal tumor constituted by spindle cells and vascular clefts, showing positivity for endothelial markers and negativity for thyroglobulin, calcitonin and TTF1. The chest CT scan performed before surgery showed multiple pulmonary nodules suggestive of secondary lesions. The patient was submitted to total thyroidectomy and lymph node dissection in order to relieve compressive symptoms. A diagnosis of thyroid angiosarcoma was made after histologic examination of the surgical specimen. Despite undergoing multiple lines of palliative chemotherapy, the pulmonary lesions increased in size and number. The patient died due to respiratory failure 29 months after the diagnosis. Thyroid angiosarcoma is a rare malignancy, generally with poor prognosis. In our case, the patient presented with pulmonary metastases at diagnosis, which is a negative prognostic factor. Due to its rarity, data regarding management and treatment of this disease are scarce. |
| first_indexed | 2024-04-12T15:22:39Z |
| format | Article |
| id | doaj.art-46e4074711954e0c962c3f4725293f21 |
| institution | Directory Open Access Journal |
| issn | 2359-4292 |
| language | English |
| last_indexed | 2024-04-12T15:22:39Z |
| publishDate | 2022-06-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj.art-46e4074711954e0c962c3f4725293f212022-12-22T03:27:22ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922022-06-0110.20945/2359-3997000000460Non-alpine primary thyroid angiosarcomaNádia Mourinho Balahttps://orcid.org/0000-0002-5834-4848Pedro Simõeshttps://orcid.org/0000-0002-4734-7621José Maria Aragüéshttps://orcid.org/0000-0003-0711-277XRicardo Veigahttps://orcid.org/0000-0001-6188-4709Sílvia Guerrahttps://orcid.org/0000-0002-1969-2487Cristina Valadashttps://orcid.org/0000-0002-2368-4447SUMMARY Thyroid angiosarcoma is an extremely rare malignancy, which occurs more frequently in the alpine region, likely associated with iodine deficiency and endemic goiter. This is an aggressive neoplasm that usually harbors a poor prognosis. We report the case of a 49-year-old Portuguese female patient presenting with a large nodule in the anterior neck region, with rapid growth and associated dysphonia. The neck ultrasound showed a hypoechogenic and heterogeneous thyroid nodule, with a larger axis of 44 mm. The fine needle aspiration cytology was not conclusive, and a biopsy of the lesion was performed. The result was suggestive of a mesenchymal tumor constituted by spindle cells and vascular clefts, showing positivity for endothelial markers and negativity for thyroglobulin, calcitonin and TTF1. The chest CT scan performed before surgery showed multiple pulmonary nodules suggestive of secondary lesions. The patient was submitted to total thyroidectomy and lymph node dissection in order to relieve compressive symptoms. A diagnosis of thyroid angiosarcoma was made after histologic examination of the surgical specimen. Despite undergoing multiple lines of palliative chemotherapy, the pulmonary lesions increased in size and number. The patient died due to respiratory failure 29 months after the diagnosis. Thyroid angiosarcoma is a rare malignancy, generally with poor prognosis. In our case, the patient presented with pulmonary metastases at diagnosis, which is a negative prognostic factor. Due to its rarity, data regarding management and treatment of this disease are scarce.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972022005006201&tlng=en |
| spellingShingle | Nádia Mourinho Bala Pedro Simões José Maria Aragüés Ricardo Veiga Sílvia Guerra Cristina Valadas Non-alpine primary thyroid angiosarcoma Archives of Endocrinology and Metabolism |
| title | Non-alpine primary thyroid angiosarcoma |
| title_full | Non-alpine primary thyroid angiosarcoma |
| title_fullStr | Non-alpine primary thyroid angiosarcoma |
| title_full_unstemmed | Non-alpine primary thyroid angiosarcoma |
| title_short | Non-alpine primary thyroid angiosarcoma |
| title_sort | non alpine primary thyroid angiosarcoma |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972022005006201&tlng=en |
| work_keys_str_mv | AT nadiamourinhobala nonalpineprimarythyroidangiosarcoma AT pedrosimoes nonalpineprimarythyroidangiosarcoma AT josemariaaragues nonalpineprimarythyroidangiosarcoma AT ricardoveiga nonalpineprimarythyroidangiosarcoma AT silviaguerra nonalpineprimarythyroidangiosarcoma AT cristinavaladas nonalpineprimarythyroidangiosarcoma |