Long-Circulating Hyaluronan-Based Nanohydrogels as Carriers of Hydrophobic Drugs
Nanohydrogels based on natural polymers, such as polysaccharides, are gaining interest as vehicles for therapeutic agents, as they can modify the pharmacokinetics and pharmacodynamics of the carried drugs. In this work, hyaluronan-riboflavin nanohydrogels were tested in vivo in healthy rats highligh...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-11-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/10/4/213 |
| _version_ | 1811183854928527360 |
|---|---|
| author | Chiara Di Meo Mayte Martínez-Martínez Tommasina Coviello Marival Bermejo Virginia Merino Isabel Gonzalez-Alvarez Marta Gonzalez-Alvarez Pietro Matricardi |
| author_facet | Chiara Di Meo Mayte Martínez-Martínez Tommasina Coviello Marival Bermejo Virginia Merino Isabel Gonzalez-Alvarez Marta Gonzalez-Alvarez Pietro Matricardi |
| author_sort | Chiara Di Meo |
| collection | DOAJ |
| description | Nanohydrogels based on natural polymers, such as polysaccharides, are gaining interest as vehicles for therapeutic agents, as they can modify the pharmacokinetics and pharmacodynamics of the carried drugs. In this work, hyaluronan-riboflavin nanohydrogels were tested in vivo in healthy rats highlighting their lack of toxicity, even at high doses, and their different biodistribution with respect to that of native hyaluronan. They were also exploited as carriers of a hydrophobic model drug, the anti-inflammatory piroxicam, that was physically embedded within the nanohydrogels by an autoclave treatment. The nanoformulation was tested by intravenous administration showing an improvement of the pharmacokinetic parameters of the molecule. The obtained results indicate that hyaluronan-based self-assembled nanohydrogels are suitable systems for low-soluble drug administration, by increasing the dose as well as the circulation time of poorly available therapeutic agents. |
| first_indexed | 2024-04-11T13:03:35Z |
| format | Article |
| id | doaj.art-46e48ebadab544848bd60ab49e8ed0b3 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-11T13:03:35Z |
| publishDate | 2018-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-46e48ebadab544848bd60ab49e8ed0b32022-12-22T04:22:50ZengMDPI AGPharmaceutics1999-49232018-11-0110421310.3390/pharmaceutics10040213pharmaceutics10040213Long-Circulating Hyaluronan-Based Nanohydrogels as Carriers of Hydrophobic DrugsChiara Di Meo0Mayte Martínez-Martínez1Tommasina Coviello2Marival Bermejo3Virginia Merino4Isabel Gonzalez-Alvarez5Marta Gonzalez-Alvarez6Pietro Matricardi7Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, ItalyDepartment of Pharmacokinetics and Pharmaceutical Technology, Miguel Hernandez University, San Juan de Alicante, 03550 Alicante, SpainDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, ItalyDepartment of Pharmacokinetics and Pharmaceutical Technology, Miguel Hernandez University, San Juan de Alicante, 03550 Alicante, SpainInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, 46100 Burjassot, SpainDepartment of Pharmacokinetics and Pharmaceutical Technology, Miguel Hernandez University, San Juan de Alicante, 03550 Alicante, SpainDepartment of Pharmacokinetics and Pharmaceutical Technology, Miguel Hernandez University, San Juan de Alicante, 03550 Alicante, SpainDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, ItalyNanohydrogels based on natural polymers, such as polysaccharides, are gaining interest as vehicles for therapeutic agents, as they can modify the pharmacokinetics and pharmacodynamics of the carried drugs. In this work, hyaluronan-riboflavin nanohydrogels were tested in vivo in healthy rats highlighting their lack of toxicity, even at high doses, and their different biodistribution with respect to that of native hyaluronan. They were also exploited as carriers of a hydrophobic model drug, the anti-inflammatory piroxicam, that was physically embedded within the nanohydrogels by an autoclave treatment. The nanoformulation was tested by intravenous administration showing an improvement of the pharmacokinetic parameters of the molecule. The obtained results indicate that hyaluronan-based self-assembled nanohydrogels are suitable systems for low-soluble drug administration, by increasing the dose as well as the circulation time of poorly available therapeutic agents.https://www.mdpi.com/1999-4923/10/4/213nanohydrogelshyaluronanriboflavinhydrophobic drugspiroxicambiodistributionpharmacokinetic |
| spellingShingle | Chiara Di Meo Mayte Martínez-Martínez Tommasina Coviello Marival Bermejo Virginia Merino Isabel Gonzalez-Alvarez Marta Gonzalez-Alvarez Pietro Matricardi Long-Circulating Hyaluronan-Based Nanohydrogels as Carriers of Hydrophobic Drugs Pharmaceutics nanohydrogels hyaluronan riboflavin hydrophobic drugs piroxicam biodistribution pharmacokinetic |
| title | Long-Circulating Hyaluronan-Based Nanohydrogels as Carriers of Hydrophobic Drugs |
| title_full | Long-Circulating Hyaluronan-Based Nanohydrogels as Carriers of Hydrophobic Drugs |
| title_fullStr | Long-Circulating Hyaluronan-Based Nanohydrogels as Carriers of Hydrophobic Drugs |
| title_full_unstemmed | Long-Circulating Hyaluronan-Based Nanohydrogels as Carriers of Hydrophobic Drugs |
| title_short | Long-Circulating Hyaluronan-Based Nanohydrogels as Carriers of Hydrophobic Drugs |
| title_sort | long circulating hyaluronan based nanohydrogels as carriers of hydrophobic drugs |
| topic | nanohydrogels hyaluronan riboflavin hydrophobic drugs piroxicam biodistribution pharmacokinetic |
| url | https://www.mdpi.com/1999-4923/10/4/213 |
| work_keys_str_mv | AT chiaradimeo longcirculatinghyaluronanbasednanohydrogelsascarriersofhydrophobicdrugs AT maytemartinezmartinez longcirculatinghyaluronanbasednanohydrogelsascarriersofhydrophobicdrugs AT tommasinacoviello longcirculatinghyaluronanbasednanohydrogelsascarriersofhydrophobicdrugs AT marivalbermejo longcirculatinghyaluronanbasednanohydrogelsascarriersofhydrophobicdrugs AT virginiamerino longcirculatinghyaluronanbasednanohydrogelsascarriersofhydrophobicdrugs AT isabelgonzalezalvarez longcirculatinghyaluronanbasednanohydrogelsascarriersofhydrophobicdrugs AT martagonzalezalvarez longcirculatinghyaluronanbasednanohydrogelsascarriersofhydrophobicdrugs AT pietromatricardi longcirculatinghyaluronanbasednanohydrogelsascarriersofhydrophobicdrugs |