Morphology-Dependent Interactions between α-Synuclein Monomers and Fibrils

Morphology-Dependent Interactions between α-Synuclein Monomers and Fibrils

Amyloid fibrils may adopt different morphologies depending on the solution conditions and the protein sequence. Here, we show that two chemically identical but morphologically distinct α-synuclein fibrils can form under identical conditions. This was observed by nuclear magnetic resonance (NMR), cir...

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Bibliographic Details
Main Authors: Tinna Pálmadóttir, Christopher A. Waudby, Katja Bernfur, John Christodoulou, Sara Linse, Anders Malmendal
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
morphology
polymorphic
monomorphic
self-assembly
NMR spectroscopy
aggregation
Online Access:https://www.mdpi.com/1422-0067/24/6/5191

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