Etiology of end-stage liver cirrhosis impacts hepatic natural killer cell heterogenicity
The natural killer (NK) cell population is a critical component of the innate immune compartment of the liver, and its functions are deeply affected by the surrounding environment. In the late stage of fibrosis, NK cells become dysfunctional, but the influence of disease etiology on NK cell behavior...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1137034/full |
| _version_ | 1797856203055824896 |
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| author | Ana C. Maretti-Mira Ana C. Maretti-Mira Matthew P. Salomon Angela M. Hsu Angela M. Hsu Lily Dara Lily Dara Lucy Golden-Mason Lucy Golden-Mason |
| author_facet | Ana C. Maretti-Mira Ana C. Maretti-Mira Matthew P. Salomon Angela M. Hsu Angela M. Hsu Lily Dara Lily Dara Lucy Golden-Mason Lucy Golden-Mason |
| author_sort | Ana C. Maretti-Mira |
| collection | DOAJ |
| description | The natural killer (NK) cell population is a critical component of the innate immune compartment of the liver, and its functions are deeply affected by the surrounding environment. In the late stage of fibrosis, NK cells become dysfunctional, but the influence of disease etiology on NK cell behavior during cirrhosis remains unclear. Using single-cell RNA sequencing (scRNA-seq), we characterized the hepatic NK cells from end-stage cirrhotic livers from subjects with non-alcoholic steatohepatitis (NASH), chronic hepatitis C infection (HCV) and primary sclerosing cholangitis (PSC). Here, we show that although NK cells shared similar dysfunctions, the disease etiology impacts hepatic NK cell heterogeneity. Therapeutical strategies targeting NK cells for the prevention or treatment of fibrosis should consider liver disease etiology in their design. |
| first_indexed | 2024-04-09T20:36:37Z |
| format | Article |
| id | doaj.art-46e8b264f1bb4683a8c7bdbfd08dc968 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-09T20:36:37Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-46e8b264f1bb4683a8c7bdbfd08dc9682023-03-30T08:05:43ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-03-011410.3389/fimmu.2023.11370341137034Etiology of end-stage liver cirrhosis impacts hepatic natural killer cell heterogenicityAna C. Maretti-Mira0Ana C. Maretti-Mira1Matthew P. Salomon2Angela M. Hsu3Angela M. Hsu4Lily Dara5Lily Dara6Lucy Golden-Mason7Lucy Golden-Mason8USC Research Center for Liver Disease, Keck School of Medicine, University of Southern California, Los Angeles, CA, United StatesDivision of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United StatesUSC Research Center for Liver Disease, Keck School of Medicine, University of Southern California, Los Angeles, CA, United StatesUSC Research Center for Liver Disease, Keck School of Medicine, University of Southern California, Los Angeles, CA, United StatesDivision of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United StatesUSC Research Center for Liver Disease, Keck School of Medicine, University of Southern California, Los Angeles, CA, United StatesDivision of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United StatesUSC Research Center for Liver Disease, Keck School of Medicine, University of Southern California, Los Angeles, CA, United StatesDivision of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United StatesThe natural killer (NK) cell population is a critical component of the innate immune compartment of the liver, and its functions are deeply affected by the surrounding environment. In the late stage of fibrosis, NK cells become dysfunctional, but the influence of disease etiology on NK cell behavior during cirrhosis remains unclear. Using single-cell RNA sequencing (scRNA-seq), we characterized the hepatic NK cells from end-stage cirrhotic livers from subjects with non-alcoholic steatohepatitis (NASH), chronic hepatitis C infection (HCV) and primary sclerosing cholangitis (PSC). Here, we show that although NK cells shared similar dysfunctions, the disease etiology impacts hepatic NK cell heterogeneity. Therapeutical strategies targeting NK cells for the prevention or treatment of fibrosis should consider liver disease etiology in their design.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1137034/fullnatural killer cellsinnate lymphocyte cellsNASHHCVPSCcirrhosis |
| spellingShingle | Ana C. Maretti-Mira Ana C. Maretti-Mira Matthew P. Salomon Angela M. Hsu Angela M. Hsu Lily Dara Lily Dara Lucy Golden-Mason Lucy Golden-Mason Etiology of end-stage liver cirrhosis impacts hepatic natural killer cell heterogenicity Frontiers in Immunology natural killer cells innate lymphocyte cells NASH HCV PSC cirrhosis |
| title | Etiology of end-stage liver cirrhosis impacts hepatic natural killer cell heterogenicity |
| title_full | Etiology of end-stage liver cirrhosis impacts hepatic natural killer cell heterogenicity |
| title_fullStr | Etiology of end-stage liver cirrhosis impacts hepatic natural killer cell heterogenicity |
| title_full_unstemmed | Etiology of end-stage liver cirrhosis impacts hepatic natural killer cell heterogenicity |
| title_short | Etiology of end-stage liver cirrhosis impacts hepatic natural killer cell heterogenicity |
| title_sort | etiology of end stage liver cirrhosis impacts hepatic natural killer cell heterogenicity |
| topic | natural killer cells innate lymphocyte cells NASH HCV PSC cirrhosis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1137034/full |
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