Female showed favorable left ventricle hypertrophy regression during post‐TAVR follow‐up
Abstract Transcatheter aortic valve replacement (TAVR) is a well‐established procedure using a catheter‐introduced valve prosthesis for patients with severe aortic stenosis (AS). This retrospective study investigated sex‐related differences in pre‐ and post‐TAVR clinical and hemodynamic outcomes and...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-04-01
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| Series: | Kaohsiung Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/kjm2.12808 |
| _version_ | 1797216963414458368 |
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| author | Cheng‐An Chiu Pin‐Rong Chen Yu‐Ju Li Chong‐Chao Hsieh Hui‐Chen Yu Chaw‐Chi Chiu Jiann‐Woei Huang Chun‐Yuan Chu Tsung‐Hsien Lin Hsiang‐Chun Lee |
| author_facet | Cheng‐An Chiu Pin‐Rong Chen Yu‐Ju Li Chong‐Chao Hsieh Hui‐Chen Yu Chaw‐Chi Chiu Jiann‐Woei Huang Chun‐Yuan Chu Tsung‐Hsien Lin Hsiang‐Chun Lee |
| author_sort | Cheng‐An Chiu |
| collection | DOAJ |
| description | Abstract Transcatheter aortic valve replacement (TAVR) is a well‐established procedure using a catheter‐introduced valve prosthesis for patients with severe aortic stenosis (AS). This retrospective study investigated sex‐related differences in pre‐ and post‐TAVR clinical and hemodynamic outcomes and analyzed data of the first 100 cases at Kaohsiung Medical University Chung‐Ho Memorial Hospital (KMUH) between December 2013 and December 2021. Baseline characteristics, procedural outcomes, mortality rates, and echocardiographic parameters were analyzed and compared between sexes. Among the 100 patients, male (46%) and female (54%) were of similar age (mean age, male 86.0 years vs. female 84.5 years) and of the same severity of AS (mean pressure gradient, male 47.5 mmHg vs. female 45.7 mmHg) at the time receiving the TAVR procedure. Women had smaller aortic valve areas calculated by continuity equation (0.8 ± 0.3 cm2 vs. 0.7 ± 0.2 cm2, p < 0.001). In addition, women had better left ventricle ejection fraction (59.6 ± 14.0% vs. men 54.7 ± 17.2%, p < 0.01). In the post‐TAVR follow‐up, regression of left ventricle mass and dimension was better in women than in men. None of the patient died within 30 days after the procedure, and women tended to have a more favorable survival than men (2‐year mortality and overall mortality rate in 8.3 year, women 9.1% and 22.2% vs. men 22.2% and 34.8%; p = 0.6385 and 0.1277, respectively). In conclusion, the sex‐based difference in post‐TAVR regression of LV remodeling suggests a need for sex‐based evaluation for patients with severe AS and their post TAVR follow‐up. |
| first_indexed | 2024-04-24T11:54:18Z |
| format | Article |
| id | doaj.art-46e8ddb175464a96bc848088db78d82c |
| institution | Directory Open Access Journal |
| issn | 1607-551X 2410-8650 |
| language | English |
| last_indexed | 2024-04-24T11:54:18Z |
| publishDate | 2024-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Kaohsiung Journal of Medical Sciences |
| spelling | doaj.art-46e8ddb175464a96bc848088db78d82c2024-04-09T05:56:39ZengWileyKaohsiung Journal of Medical Sciences1607-551X2410-86502024-04-0140438439410.1002/kjm2.12808Female showed favorable left ventricle hypertrophy regression during post‐TAVR follow‐upCheng‐An Chiu0Pin‐Rong Chen1Yu‐Ju Li2Chong‐Chao Hsieh3Hui‐Chen Yu4Chaw‐Chi Chiu5Jiann‐Woei Huang6Chun‐Yuan Chu7Tsung‐Hsien Lin8Hsiang‐Chun Lee9Division of Cardiology, Department of Internal Medicine Kaohsiung Medical University Hospital, Kaohsiung Medical University Kaohsiung TaiwanSchool of Medicine, College of Medicine Kaohsiung Medical University Kaohsiung TaiwanDivision of Cardiology, Department of Internal Medicine Kaohsiung Medical University Hospital, Kaohsiung Medical University Kaohsiung TaiwanDivision of Cardiovascular Surgery and Department of Surgery Kaohsiung Medical University Hospital Kaohsiung TaiwanDivision of Cardiovascular Surgery and Department of Surgery Kaohsiung Medical University Hospital Kaohsiung TaiwanDivision of Cardiovascular Surgery and Department of Surgery Kaohsiung Medical University Hospital Kaohsiung TaiwanDivision of Cardiovascular Surgery and Department of Surgery Kaohsiung Medical University Hospital Kaohsiung TaiwanDivision of Cardiology, Department of Internal Medicine Kaohsiung Medical University Hospital, Kaohsiung Medical University Kaohsiung TaiwanDivision of Cardiology, Department of Internal Medicine Kaohsiung Medical University Hospital, Kaohsiung Medical University Kaohsiung TaiwanDivision of Cardiology, Department of Internal Medicine Kaohsiung Medical University Hospital, Kaohsiung Medical University Kaohsiung TaiwanAbstract Transcatheter aortic valve replacement (TAVR) is a well‐established procedure using a catheter‐introduced valve prosthesis for patients with severe aortic stenosis (AS). This retrospective study investigated sex‐related differences in pre‐ and post‐TAVR clinical and hemodynamic outcomes and analyzed data of the first 100 cases at Kaohsiung Medical University Chung‐Ho Memorial Hospital (KMUH) between December 2013 and December 2021. Baseline characteristics, procedural outcomes, mortality rates, and echocardiographic parameters were analyzed and compared between sexes. Among the 100 patients, male (46%) and female (54%) were of similar age (mean age, male 86.0 years vs. female 84.5 years) and of the same severity of AS (mean pressure gradient, male 47.5 mmHg vs. female 45.7 mmHg) at the time receiving the TAVR procedure. Women had smaller aortic valve areas calculated by continuity equation (0.8 ± 0.3 cm2 vs. 0.7 ± 0.2 cm2, p < 0.001). In addition, women had better left ventricle ejection fraction (59.6 ± 14.0% vs. men 54.7 ± 17.2%, p < 0.01). In the post‐TAVR follow‐up, regression of left ventricle mass and dimension was better in women than in men. None of the patient died within 30 days after the procedure, and women tended to have a more favorable survival than men (2‐year mortality and overall mortality rate in 8.3 year, women 9.1% and 22.2% vs. men 22.2% and 34.8%; p = 0.6385 and 0.1277, respectively). In conclusion, the sex‐based difference in post‐TAVR regression of LV remodeling suggests a need for sex‐based evaluation for patients with severe AS and their post TAVR follow‐up.https://doi.org/10.1002/kjm2.12808aortic stenosis (AS)echocardiographysex differencestranscatheter aortic valve replacement (TAVR) |
| spellingShingle | Cheng‐An Chiu Pin‐Rong Chen Yu‐Ju Li Chong‐Chao Hsieh Hui‐Chen Yu Chaw‐Chi Chiu Jiann‐Woei Huang Chun‐Yuan Chu Tsung‐Hsien Lin Hsiang‐Chun Lee Female showed favorable left ventricle hypertrophy regression during post‐TAVR follow‐up Kaohsiung Journal of Medical Sciences aortic stenosis (AS) echocardiography sex differences transcatheter aortic valve replacement (TAVR) |
| title | Female showed favorable left ventricle hypertrophy regression during post‐TAVR follow‐up |
| title_full | Female showed favorable left ventricle hypertrophy regression during post‐TAVR follow‐up |
| title_fullStr | Female showed favorable left ventricle hypertrophy regression during post‐TAVR follow‐up |
| title_full_unstemmed | Female showed favorable left ventricle hypertrophy regression during post‐TAVR follow‐up |
| title_short | Female showed favorable left ventricle hypertrophy regression during post‐TAVR follow‐up |
| title_sort | female showed favorable left ventricle hypertrophy regression during post tavr follow up |
| topic | aortic stenosis (AS) echocardiography sex differences transcatheter aortic valve replacement (TAVR) |
| url | https://doi.org/10.1002/kjm2.12808 |
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