Epitopia: a web-server for predicting B-cell epitopes
<p>Abstract</p> <p>Background</p> <p>Detecting candidate B-cell epitopes in a protein is a basic and fundamental step in many immunological applications. Due to the impracticality of experimental approaches to systematically scan the entire protein, a computational tool...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2009-09-01
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| Series: | BMC Bioinformatics |
| Online Access: | http://www.biomedcentral.com/1471-2105/10/287 |
| _version_ | 1818498007970086912 |
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| author | Martz Eric Mayrose Itay Rubinstein Nimrod D Pupko Tal |
| author_facet | Martz Eric Mayrose Itay Rubinstein Nimrod D Pupko Tal |
| author_sort | Martz Eric |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Detecting candidate B-cell epitopes in a protein is a basic and fundamental step in many immunological applications. Due to the impracticality of experimental approaches to systematically scan the entire protein, a computational tool that predicts the most probable epitope regions is desirable.</p> <p>Results</p> <p>The Epitopia server is a web-based tool that aims to predict immunogenic regions in either a protein three-dimensional structure or a linear sequence. Epitopia implements a machine-learning algorithm that was trained to discern antigenic features within a given protein. The Epitopia algorithm has been compared to other available epitope prediction tools and was found to have higher predictive power. A special emphasis was put on the development of a user-friendly graphical interface for displaying the results.</p> <p>Conclusion</p> <p>Epitopia is a user-friendly web-server that predicts immunogenic regions for both a protein structure and a protein sequence. Its accuracy and functionality make it a highly useful tool. Epitopia is available at <url>http://epitopia.tau.ac.il</url> and includes extensive explanations and example predictions.</p> |
| first_indexed | 2024-12-10T18:52:27Z |
| format | Article |
| id | doaj.art-46e95f51b782459ca227c4b82cd4f136 |
| institution | Directory Open Access Journal |
| issn | 1471-2105 |
| language | English |
| last_indexed | 2024-12-10T18:52:27Z |
| publishDate | 2009-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Bioinformatics |
| spelling | doaj.art-46e95f51b782459ca227c4b82cd4f1362022-12-22T01:37:16ZengBMCBMC Bioinformatics1471-21052009-09-0110128710.1186/1471-2105-10-287Epitopia: a web-server for predicting B-cell epitopesMartz EricMayrose ItayRubinstein Nimrod DPupko Tal<p>Abstract</p> <p>Background</p> <p>Detecting candidate B-cell epitopes in a protein is a basic and fundamental step in many immunological applications. Due to the impracticality of experimental approaches to systematically scan the entire protein, a computational tool that predicts the most probable epitope regions is desirable.</p> <p>Results</p> <p>The Epitopia server is a web-based tool that aims to predict immunogenic regions in either a protein three-dimensional structure or a linear sequence. Epitopia implements a machine-learning algorithm that was trained to discern antigenic features within a given protein. The Epitopia algorithm has been compared to other available epitope prediction tools and was found to have higher predictive power. A special emphasis was put on the development of a user-friendly graphical interface for displaying the results.</p> <p>Conclusion</p> <p>Epitopia is a user-friendly web-server that predicts immunogenic regions for both a protein structure and a protein sequence. Its accuracy and functionality make it a highly useful tool. Epitopia is available at <url>http://epitopia.tau.ac.il</url> and includes extensive explanations and example predictions.</p>http://www.biomedcentral.com/1471-2105/10/287 |
| spellingShingle | Martz Eric Mayrose Itay Rubinstein Nimrod D Pupko Tal Epitopia: a web-server for predicting B-cell epitopes BMC Bioinformatics |
| title | Epitopia: a web-server for predicting B-cell epitopes |
| title_full | Epitopia: a web-server for predicting B-cell epitopes |
| title_fullStr | Epitopia: a web-server for predicting B-cell epitopes |
| title_full_unstemmed | Epitopia: a web-server for predicting B-cell epitopes |
| title_short | Epitopia: a web-server for predicting B-cell epitopes |
| title_sort | epitopia a web server for predicting b cell epitopes |
| url | http://www.biomedcentral.com/1471-2105/10/287 |
| work_keys_str_mv | AT martzeric epitopiaawebserverforpredictingbcellepitopes AT mayroseitay epitopiaawebserverforpredictingbcellepitopes AT rubinsteinnimrodd epitopiaawebserverforpredictingbcellepitopes AT pupkotal epitopiaawebserverforpredictingbcellepitopes |