Effects of cardiac function alterations on the risk of postoperative thrombotic complications in patients receiving endovascular aortic repair
Introduction: Chronic heart disease (CHD) is a common comorbidity of patients receiving endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms (AAA). The explicit relationship between ventricular systolic function and EVAR complication of thrombotic events is unknown.Methods: In this stu...
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.1114110/full |
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| author | Xiaoning Sun Xiaoning Sun Siting Li Siting Li Yuan He Yuxi Liu Tianxiang Ma Rong Zeng Zhili Liu Yu Chen Yuehong Zheng Yuehong Zheng Xiao Liu |
| author_facet | Xiaoning Sun Xiaoning Sun Siting Li Siting Li Yuan He Yuxi Liu Tianxiang Ma Rong Zeng Zhili Liu Yu Chen Yuehong Zheng Yuehong Zheng Xiao Liu |
| author_sort | Xiaoning Sun |
| collection | DOAJ |
| description | Introduction: Chronic heart disease (CHD) is a common comorbidity of patients receiving endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms (AAA). The explicit relationship between ventricular systolic function and EVAR complication of thrombotic events is unknown.Methods: In this study, we proposed a three-dimensional numerical model coupled with the lumped-elements heart model, which is capable of simulating thrombus formation in diverse systolic functions. The relation of cardiac functions and the predicted risk of thrombus formation in the aorta and/or endograft of 4 patients who underwent EVAR was investigated. Relative risks for thrombus formation were identified using machine-learning algorithms.Results: The computational results demonstrate that thrombus tended to form on the interior side of the aorta arch and iliac branches, and cardiac function can affect blood flow field and affect thrombus formation, which is consistent with the four patients' post-operative imaging follow-up. We also found that RRT, OSI, TAWSS in thrombosis area are lower than whole average. In addition, we found that the thrombus formation has negative correlations with the maximum ventricular contractile force (r = −.281 ± .101) and positive correlations with the minimum ventricular contractile force (r = .238 ± .074), whereas the effect of heart rate (r = −.015 ± .121) on thrombus formation is not significant.Conclusion: In conclusion, changes in ventricular systolic function may alter the risk of thrombotic events after EVAR repair, which could provide insight into the selection of adjuvant therapy strategies for AAA patients with CHD. |
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| last_indexed | 2024-04-10T23:51:09Z |
| publishDate | 2023-01-01 |
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| series | Frontiers in Physiology |
| spelling | doaj.art-46e9ed17c6a442d38a62dcd4aba65b112023-01-10T18:20:33ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-01-011310.3389/fphys.2022.11141101114110Effects of cardiac function alterations on the risk of postoperative thrombotic complications in patients receiving endovascular aortic repairXiaoning Sun0Xiaoning Sun1Siting Li2Siting Li3Yuan He4Yuxi Liu5Tianxiang Ma6Rong Zeng7Zhili Liu8Yu Chen9Yuehong Zheng10Yuehong Zheng11Xiao Liu12Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, ChinaDepartment, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaDepartment of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, ChinaDepartment, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaKey Laboratory of Biomechanics and Mechanobiology, Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, ChinaKey Laboratory of Biomechanics and Mechanobiology, Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, ChinaKey Laboratory of Biomechanics and Mechanobiology, Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, ChinaDepartment of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, ChinaDepartment of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, ChinaKey Laboratory of Biomechanics and Mechanobiology, Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, ChinaDepartment of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, ChinaDepartment, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaKey Laboratory of Biomechanics and Mechanobiology, Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, ChinaIntroduction: Chronic heart disease (CHD) is a common comorbidity of patients receiving endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms (AAA). The explicit relationship between ventricular systolic function and EVAR complication of thrombotic events is unknown.Methods: In this study, we proposed a three-dimensional numerical model coupled with the lumped-elements heart model, which is capable of simulating thrombus formation in diverse systolic functions. The relation of cardiac functions and the predicted risk of thrombus formation in the aorta and/or endograft of 4 patients who underwent EVAR was investigated. Relative risks for thrombus formation were identified using machine-learning algorithms.Results: The computational results demonstrate that thrombus tended to form on the interior side of the aorta arch and iliac branches, and cardiac function can affect blood flow field and affect thrombus formation, which is consistent with the four patients' post-operative imaging follow-up. We also found that RRT, OSI, TAWSS in thrombosis area are lower than whole average. In addition, we found that the thrombus formation has negative correlations with the maximum ventricular contractile force (r = −.281 ± .101) and positive correlations with the minimum ventricular contractile force (r = .238 ± .074), whereas the effect of heart rate (r = −.015 ± .121) on thrombus formation is not significant.Conclusion: In conclusion, changes in ventricular systolic function may alter the risk of thrombotic events after EVAR repair, which could provide insight into the selection of adjuvant therapy strategies for AAA patients with CHD.https://www.frontiersin.org/articles/10.3389/fphys.2022.1114110/fullthrombushemodynamicscomputational modelventricular systolic functionabdominal aortic aneurysms |
| spellingShingle | Xiaoning Sun Xiaoning Sun Siting Li Siting Li Yuan He Yuxi Liu Tianxiang Ma Rong Zeng Zhili Liu Yu Chen Yuehong Zheng Yuehong Zheng Xiao Liu Effects of cardiac function alterations on the risk of postoperative thrombotic complications in patients receiving endovascular aortic repair Frontiers in Physiology thrombus hemodynamics computational model ventricular systolic function abdominal aortic aneurysms |
| title | Effects of cardiac function alterations on the risk of postoperative thrombotic complications in patients receiving endovascular aortic repair |
| title_full | Effects of cardiac function alterations on the risk of postoperative thrombotic complications in patients receiving endovascular aortic repair |
| title_fullStr | Effects of cardiac function alterations on the risk of postoperative thrombotic complications in patients receiving endovascular aortic repair |
| title_full_unstemmed | Effects of cardiac function alterations on the risk of postoperative thrombotic complications in patients receiving endovascular aortic repair |
| title_short | Effects of cardiac function alterations on the risk of postoperative thrombotic complications in patients receiving endovascular aortic repair |
| title_sort | effects of cardiac function alterations on the risk of postoperative thrombotic complications in patients receiving endovascular aortic repair |
| topic | thrombus hemodynamics computational model ventricular systolic function abdominal aortic aneurysms |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.1114110/full |
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