A Mouse Model That Reproduces the Developmental Pathways and Site Specificity of the Cancers Associated With the Human BRCA1 Mutation Carrier State

A Mouse Model That Reproduces the Developmental Pathways and Site Specificity of the Cancers Associated With the Human BRCA1 Mutation Carrier State

Predisposition to breast and extrauterine Müllerian carcinomas in BRCA1 mutation carriers is due to a combination of cell-autonomous consequences of BRCA1 inactivation on cell cycle homeostasis superimposed on cell-nonautonomous hormonal factors magnified by the effects of BRCA1 mutations on hormona...

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Bibliographic Details
Main Authors: Ying Liu, Hai-Yun Yen, Theresa Austria, Jonas Pettersson, Janos Peti-Peterdi, Robert Maxson, Martin Widschwendter, Louis Dubeau
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:EBioMedicine
Subjects:
Brca1
Familial cancer predisposition
Müllerian inhibiting substance
Mouse model of breast and ovarian cancer
Cell non-autonomous mechanism of cancer predisposition
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415301171

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