Pathogen recognition by sensory neurons: hypotheses on the specificity of sensory neuron signaling
Sensory neurons cooperate with barrier tissues and resident immune cells to form a significant aspect of defensive strategies in concert with the immune system. This assembly of neuroimmune cellular units is exemplified across evolution from early metazoans to mammalian life. As such, sensory neuron...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1184000/full |
| _version_ | 1797834665038446592 |
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| author | Antoine Millet Nicholas Jendzjowsky Nicholas Jendzjowsky |
| author_facet | Antoine Millet Nicholas Jendzjowsky Nicholas Jendzjowsky |
| author_sort | Antoine Millet |
| collection | DOAJ |
| description | Sensory neurons cooperate with barrier tissues and resident immune cells to form a significant aspect of defensive strategies in concert with the immune system. This assembly of neuroimmune cellular units is exemplified across evolution from early metazoans to mammalian life. As such, sensory neurons possess the capability to detect pathogenic infiltrates at barrier surfaces. This capacity relies on mechanisms that unleash specific cell signaling, trafficking and defensive reflexes. These pathways exploit mechanisms to amplify and enhance the alerting response should pathogenic infiltration seep into other tissue compartments and/or systemic circulation. Here we explore two hypotheses: 1) that sensory neurons’ potential cellular signaling pathways require the interaction of pathogen recognition receptors and ion channels specific to sensory neurons and; 2) mechanisms which amplify these sensing pathways require activation of multiple sensory neuron sites. Where possible, we provide references to other apt reviews which provide the reader more detail on specific aspects of the perspectives provided here. |
| first_indexed | 2024-04-09T14:42:12Z |
| format | Article |
| id | doaj.art-46eb5ce74ceb475393c26a4cc5d66246 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-09T14:42:12Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-46eb5ce74ceb475393c26a4cc5d662462023-05-03T05:26:03ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-05-011410.3389/fimmu.2023.11840001184000Pathogen recognition by sensory neurons: hypotheses on the specificity of sensory neuron signalingAntoine Millet0Nicholas Jendzjowsky1Nicholas Jendzjowsky2Respiratory & Exercise Physiology, The Lundquist Institute for Biomedical Innovation at Harbor University of California Los Angeles (UCLA) Medical Center, Torrance, CA, United StatesRespiratory & Exercise Physiology, The Lundquist Institute for Biomedical Innovation at Harbor University of California Los Angeles (UCLA) Medical Center, Torrance, CA, United StatesDivision of Respiratory and Critical Care Medicine and Physiology, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, United StatesSensory neurons cooperate with barrier tissues and resident immune cells to form a significant aspect of defensive strategies in concert with the immune system. This assembly of neuroimmune cellular units is exemplified across evolution from early metazoans to mammalian life. As such, sensory neurons possess the capability to detect pathogenic infiltrates at barrier surfaces. This capacity relies on mechanisms that unleash specific cell signaling, trafficking and defensive reflexes. These pathways exploit mechanisms to amplify and enhance the alerting response should pathogenic infiltration seep into other tissue compartments and/or systemic circulation. Here we explore two hypotheses: 1) that sensory neurons’ potential cellular signaling pathways require the interaction of pathogen recognition receptors and ion channels specific to sensory neurons and; 2) mechanisms which amplify these sensing pathways require activation of multiple sensory neuron sites. Where possible, we provide references to other apt reviews which provide the reader more detail on specific aspects of the perspectives provided here.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1184000/fullpathogen recognition receptors (PRR)pathogen associated molecular patterns (PAMPs)transient receptor potential channelsensory neurondorsal root ganglion (DRG)vagus |
| spellingShingle | Antoine Millet Nicholas Jendzjowsky Nicholas Jendzjowsky Pathogen recognition by sensory neurons: hypotheses on the specificity of sensory neuron signaling Frontiers in Immunology pathogen recognition receptors (PRR) pathogen associated molecular patterns (PAMPs) transient receptor potential channel sensory neuron dorsal root ganglion (DRG) vagus |
| title | Pathogen recognition by sensory neurons: hypotheses on the specificity of sensory neuron signaling |
| title_full | Pathogen recognition by sensory neurons: hypotheses on the specificity of sensory neuron signaling |
| title_fullStr | Pathogen recognition by sensory neurons: hypotheses on the specificity of sensory neuron signaling |
| title_full_unstemmed | Pathogen recognition by sensory neurons: hypotheses on the specificity of sensory neuron signaling |
| title_short | Pathogen recognition by sensory neurons: hypotheses on the specificity of sensory neuron signaling |
| title_sort | pathogen recognition by sensory neurons hypotheses on the specificity of sensory neuron signaling |
| topic | pathogen recognition receptors (PRR) pathogen associated molecular patterns (PAMPs) transient receptor potential channel sensory neuron dorsal root ganglion (DRG) vagus |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1184000/full |
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