New insights into the interplay between autophagy and cartilage degeneration in osteoarthritis
Autophagy is an intracellular degradation system that maintains the stable state of cell energy metabolism. Some recent findings have indicated that autophagy dysfunction is an important driving factor for the occurrence and development of osteoarthritis (OA). The decrease of autophagy leads to the...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.1089668/full |
| _version_ | 1797985267301220352 |
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| author | Xiaoman Lv Ting Zhao Youwu Dai Mingqin Shi Xiaoyi Huang Yuanyuan Wei Jiayan Shen Xiaoyu Zhang Zhaohu Xie Qi Wang Zhaofu Li Dongdong Qin |
| author_facet | Xiaoman Lv Ting Zhao Youwu Dai Mingqin Shi Xiaoyi Huang Yuanyuan Wei Jiayan Shen Xiaoyu Zhang Zhaohu Xie Qi Wang Zhaofu Li Dongdong Qin |
| author_sort | Xiaoman Lv |
| collection | DOAJ |
| description | Autophagy is an intracellular degradation system that maintains the stable state of cell energy metabolism. Some recent findings have indicated that autophagy dysfunction is an important driving factor for the occurrence and development of osteoarthritis (OA). The decrease of autophagy leads to the accumulation of damaged organelles and macromolecules in chondrocytes, which affects the survival of chondrocytes and ultimately leads to OA. An appropriate level of autophagic activation may be a new method to prevent articular cartilage degeneration in OA. This minireview discussed the mechanism of autophagy and OA, key autophagy targets regulating OA progression, and evaluated therapeutic applications of drugs targeting autophagy in preclinical and clinical research. Some critical issues worth paying attention to were also raised to guide future research efforts. |
| first_indexed | 2024-04-11T07:15:23Z |
| format | Article |
| id | doaj.art-46ecb7718db148188b1fd03335f8e226 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-11T07:15:23Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-46ecb7718db148188b1fd03335f8e2262022-12-22T04:38:00ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-12-011010.3389/fcell.2022.10896681089668New insights into the interplay between autophagy and cartilage degeneration in osteoarthritisXiaoman Lv0Ting Zhao1Youwu Dai2Mingqin Shi3Xiaoyi Huang4Yuanyuan Wei5Jiayan Shen6Xiaoyu Zhang7Zhaohu Xie8Qi Wang9Zhaofu Li10Dongdong Qin11School of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, ChinaThe First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, ChinaSchool of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, ChinaSchool of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, ChinaSchool of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, ChinaSchool of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, ChinaThe First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, ChinaThe First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, ChinaSchool of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, ChinaThe First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, ChinaSchool of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, ChinaSchool of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, ChinaAutophagy is an intracellular degradation system that maintains the stable state of cell energy metabolism. Some recent findings have indicated that autophagy dysfunction is an important driving factor for the occurrence and development of osteoarthritis (OA). The decrease of autophagy leads to the accumulation of damaged organelles and macromolecules in chondrocytes, which affects the survival of chondrocytes and ultimately leads to OA. An appropriate level of autophagic activation may be a new method to prevent articular cartilage degeneration in OA. This minireview discussed the mechanism of autophagy and OA, key autophagy targets regulating OA progression, and evaluated therapeutic applications of drugs targeting autophagy in preclinical and clinical research. Some critical issues worth paying attention to were also raised to guide future research efforts.https://www.frontiersin.org/articles/10.3389/fcell.2022.1089668/fullautophagyosteoarthritismechanismtherapeutic applicationspreclinical and clinical research |
| spellingShingle | Xiaoman Lv Ting Zhao Youwu Dai Mingqin Shi Xiaoyi Huang Yuanyuan Wei Jiayan Shen Xiaoyu Zhang Zhaohu Xie Qi Wang Zhaofu Li Dongdong Qin New insights into the interplay between autophagy and cartilage degeneration in osteoarthritis Frontiers in Cell and Developmental Biology autophagy osteoarthritis mechanism therapeutic applications preclinical and clinical research |
| title | New insights into the interplay between autophagy and cartilage degeneration in osteoarthritis |
| title_full | New insights into the interplay between autophagy and cartilage degeneration in osteoarthritis |
| title_fullStr | New insights into the interplay between autophagy and cartilage degeneration in osteoarthritis |
| title_full_unstemmed | New insights into the interplay between autophagy and cartilage degeneration in osteoarthritis |
| title_short | New insights into the interplay between autophagy and cartilage degeneration in osteoarthritis |
| title_sort | new insights into the interplay between autophagy and cartilage degeneration in osteoarthritis |
| topic | autophagy osteoarthritis mechanism therapeutic applications preclinical and clinical research |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.1089668/full |
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