Hold on or Cut? Integrin- and MMP-Mediated Cell–Matrix Interactions in the Tumor Microenvironment
The tumor microenvironment (TME) has become the focus of interest in cancer research and treatment. It includes the extracellular matrix (ECM) and ECM-modifying enzymes that are secreted by cancer and neighboring cells. The ECM serves both to anchor the tumor cells embedded in it and as a means of c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/1/238 |
| _version_ | 1797543292647243776 |
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| author | Stephan Niland Johannes A. Eble |
| author_facet | Stephan Niland Johannes A. Eble |
| author_sort | Stephan Niland |
| collection | DOAJ |
| description | The tumor microenvironment (TME) has become the focus of interest in cancer research and treatment. It includes the extracellular matrix (ECM) and ECM-modifying enzymes that are secreted by cancer and neighboring cells. The ECM serves both to anchor the tumor cells embedded in it and as a means of communication between the various cellular and non-cellular components of the TME. The cells of the TME modify their surrounding cancer-characteristic ECM. This in turn provides feedback to them via cellular receptors, thereby regulating, together with cytokines and exosomes, differentiation processes as well as tumor progression and spread. Matrix remodeling is accomplished by altering the repertoire of ECM components and by biophysical changes in stiffness and tension caused by ECM-crosslinking and ECM-degrading enzymes, in particular matrix metalloproteinases (MMPs). These can degrade ECM barriers or, by partial proteolysis, release soluble ECM fragments called matrikines, which influence cells inside and outside the TME. This review examines the changes in the ECM of the TME and the interaction between cells and the ECM, with a particular focus on MMPs. |
| first_indexed | 2024-03-10T13:42:30Z |
| format | Article |
| id | doaj.art-46ee03b1b4e7470186425e8ba0e21feb |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T13:42:30Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-46ee03b1b4e7470186425e8ba0e21feb2023-11-21T02:52:39ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-12-0122123810.3390/ijms22010238Hold on or Cut? Integrin- and MMP-Mediated Cell–Matrix Interactions in the Tumor MicroenvironmentStephan Niland0Johannes A. Eble1Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, 48149 Münster, GermanyInstitute of Physiological Chemistry and Pathobiochemistry, University of Münster, 48149 Münster, GermanyThe tumor microenvironment (TME) has become the focus of interest in cancer research and treatment. It includes the extracellular matrix (ECM) and ECM-modifying enzymes that are secreted by cancer and neighboring cells. The ECM serves both to anchor the tumor cells embedded in it and as a means of communication between the various cellular and non-cellular components of the TME. The cells of the TME modify their surrounding cancer-characteristic ECM. This in turn provides feedback to them via cellular receptors, thereby regulating, together with cytokines and exosomes, differentiation processes as well as tumor progression and spread. Matrix remodeling is accomplished by altering the repertoire of ECM components and by biophysical changes in stiffness and tension caused by ECM-crosslinking and ECM-degrading enzymes, in particular matrix metalloproteinases (MMPs). These can degrade ECM barriers or, by partial proteolysis, release soluble ECM fragments called matrikines, which influence cells inside and outside the TME. This review examines the changes in the ECM of the TME and the interaction between cells and the ECM, with a particular focus on MMPs.https://www.mdpi.com/1422-0067/22/1/238tumor microenvironmentextracellular matrixintegrinsmatrix metalloproteinasesmatrikines |
| spellingShingle | Stephan Niland Johannes A. Eble Hold on or Cut? Integrin- and MMP-Mediated Cell–Matrix Interactions in the Tumor Microenvironment International Journal of Molecular Sciences tumor microenvironment extracellular matrix integrins matrix metalloproteinases matrikines |
| title | Hold on or Cut? Integrin- and MMP-Mediated Cell–Matrix Interactions in the Tumor Microenvironment |
| title_full | Hold on or Cut? Integrin- and MMP-Mediated Cell–Matrix Interactions in the Tumor Microenvironment |
| title_fullStr | Hold on or Cut? Integrin- and MMP-Mediated Cell–Matrix Interactions in the Tumor Microenvironment |
| title_full_unstemmed | Hold on or Cut? Integrin- and MMP-Mediated Cell–Matrix Interactions in the Tumor Microenvironment |
| title_short | Hold on or Cut? Integrin- and MMP-Mediated Cell–Matrix Interactions in the Tumor Microenvironment |
| title_sort | hold on or cut integrin and mmp mediated cell matrix interactions in the tumor microenvironment |
| topic | tumor microenvironment extracellular matrix integrins matrix metalloproteinases matrikines |
| url | https://www.mdpi.com/1422-0067/22/1/238 |
| work_keys_str_mv | AT stephanniland holdonorcutintegrinandmmpmediatedcellmatrixinteractionsinthetumormicroenvironment AT johannesaeble holdonorcutintegrinandmmpmediatedcellmatrixinteractionsinthetumormicroenvironment |