Quercetin Increases MUC2 and MUC5AC Gene Expression and Secretion in Intestinal Goblet Cell-Like LS174T via PLC/PKCα/ERK1-2 Pathway

Quercetin Increases MUC2 and MUC5AC Gene Expression and Secretion in Intestinal Goblet Cell-Like LS174T via PLC/PKCα/ERK1-2 Pathway

The main dietary flavonoid quercetin, is known to preserve the integrity of gastrointestinal barrier and to have anti-inflammatory, anti-cancer, anti-fibrotic, and other beneficial properties. Many of the biological effects of quercetin appear to be associated to the modulation of cell signaling pat...

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Bibliographic Details
Main Authors: Simona Damiano, Anna Sasso, Bruna De Felice, Ilaria Di Gregorio, Giuliana La Rosa, Gelsi A. Lupoli, Anna Belfiore, Paolo Mondola, Mariarosaria Santillo
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Physiology
Subjects:
quercetin
MUC2
MUC5AC
goblet cells
mucin secretion
gastrointestinal barrier
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2018.00357/full

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