Pancreatic adenocarcinoma in the elderly – recurrence and survival: A physician's challenge
Pancreatic Ductal Adenocarcinomas (PDAC) is one of the most lethal cancer, shifting it from the fourth highest to the third-highest cause of cancer-related deaths in the United States recently. The majority of the cases are diagnosed when the disease has metastasized and is associated with poor 5-ye...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Advances in Cancer Biology - Metastasis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667394023000060 |
| _version_ | 1797799887470854144 |
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| author | Mashood Iqbal Uzzam Ahmed Khawaja Umar Soomro Syed A.A. Rizvi Zoya H. Rizvi |
| author_facet | Mashood Iqbal Uzzam Ahmed Khawaja Umar Soomro Syed A.A. Rizvi Zoya H. Rizvi |
| author_sort | Mashood Iqbal |
| collection | DOAJ |
| description | Pancreatic Ductal Adenocarcinomas (PDAC) is one of the most lethal cancer, shifting it from the fourth highest to the third-highest cause of cancer-related deaths in the United States recently. The majority of the cases are diagnosed when the disease has metastasized and is associated with poor 5-year survival. A long-term survival data of PDAC has not been well reported in the literature. Pancreatic Cancer requires the imminent need of a multidisciplinary approach. The key to an improved long-term outcome involves early diagnosis and curative resection along with chemotherapeutic agents. Gemcitabine has played a positive role as an adjuvant after surgical resection. Regular follow-ups post-resection are mandatory for the detection of neoplastic recurrence. To add to what is already a challenging task, isolated recurrence of PDAC poses greater challenges for the physicians treating the patients because there is no general consensus on how to manage these specific groups of patients. To effectively handle this challenging task, a definite strategy must be adopted. Long-term survival if accomplished must therefore be accompanied by regular follow-up visits including Spiral CT scans and keeping an eye on the serum tumor marker CA19-9, a prognostic survival predictor. |
| first_indexed | 2024-03-13T04:25:42Z |
| format | Article |
| id | doaj.art-46f0d5387bae4d729d10dc6eca652d64 |
| institution | Directory Open Access Journal |
| issn | 2667-3940 |
| language | English |
| last_indexed | 2024-03-13T04:25:42Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advances in Cancer Biology - Metastasis |
| spelling | doaj.art-46f0d5387bae4d729d10dc6eca652d642023-06-20T04:21:28ZengElsevierAdvances in Cancer Biology - Metastasis2667-39402023-07-017100092Pancreatic adenocarcinoma in the elderly – recurrence and survival: A physician's challengeMashood Iqbal0Uzzam Ahmed Khawaja1Umar Soomro2Syed A.A. Rizvi3Zoya H. Rizvi4Department of Internal Medicine, Jinnah Medical and Dental College, Karachi, Pakistan; Corresponding author. Department of Internal Medicine, Jinnah Medical and Dental College, Karachi, Pakistan.Department of Internal Medicine, Jinnah Medical and Dental College, Karachi, PakistanDepartment of Surgery, Jinnah Medical and Dental College, Karachi, PakistanLarkin University, College of Biomedical Sciences, Miami, Florida, USA; Corresponding author. College of Biomedical Sciences, Larkin University, Miami, FL, USA.Adlai E. Stevenson High School, Lincolnshire, IL, USAPancreatic Ductal Adenocarcinomas (PDAC) is one of the most lethal cancer, shifting it from the fourth highest to the third-highest cause of cancer-related deaths in the United States recently. The majority of the cases are diagnosed when the disease has metastasized and is associated with poor 5-year survival. A long-term survival data of PDAC has not been well reported in the literature. Pancreatic Cancer requires the imminent need of a multidisciplinary approach. The key to an improved long-term outcome involves early diagnosis and curative resection along with chemotherapeutic agents. Gemcitabine has played a positive role as an adjuvant after surgical resection. Regular follow-ups post-resection are mandatory for the detection of neoplastic recurrence. To add to what is already a challenging task, isolated recurrence of PDAC poses greater challenges for the physicians treating the patients because there is no general consensus on how to manage these specific groups of patients. To effectively handle this challenging task, a definite strategy must be adopted. Long-term survival if accomplished must therefore be accompanied by regular follow-up visits including Spiral CT scans and keeping an eye on the serum tumor marker CA19-9, a prognostic survival predictor.http://www.sciencedirect.com/science/article/pii/S2667394023000060Pancreatic ductal adenocarcinoma (PDAC)Spiral CT scanSerum tumor marker CA 19–9 |
| spellingShingle | Mashood Iqbal Uzzam Ahmed Khawaja Umar Soomro Syed A.A. Rizvi Zoya H. Rizvi Pancreatic adenocarcinoma in the elderly – recurrence and survival: A physician's challenge Advances in Cancer Biology - Metastasis Pancreatic ductal adenocarcinoma (PDAC) Spiral CT scan Serum tumor marker CA 19–9 |
| title | Pancreatic adenocarcinoma in the elderly – recurrence and survival: A physician's challenge |
| title_full | Pancreatic adenocarcinoma in the elderly – recurrence and survival: A physician's challenge |
| title_fullStr | Pancreatic adenocarcinoma in the elderly – recurrence and survival: A physician's challenge |
| title_full_unstemmed | Pancreatic adenocarcinoma in the elderly – recurrence and survival: A physician's challenge |
| title_short | Pancreatic adenocarcinoma in the elderly – recurrence and survival: A physician's challenge |
| title_sort | pancreatic adenocarcinoma in the elderly recurrence and survival a physician s challenge |
| topic | Pancreatic ductal adenocarcinoma (PDAC) Spiral CT scan Serum tumor marker CA 19–9 |
| url | http://www.sciencedirect.com/science/article/pii/S2667394023000060 |
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