Characterizing physical properties and in vivo OCT imaging study of Cu-Sn-S nanocrystals
Highly yield Cu2SnS3 nanocrystals (CTS NCs) have been attracted more attentions in these years, the CTS NCs with strong absorption in near-infrared (NIR) region which can serve as the contrast agent of Optical Coherence Tomography (OCT) imaging. These NCs can be synthesized by facile method, and exh...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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AIP Publishing LLC
2017-01-01
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| Series: | AIP Advances |
| Online Access: | http://dx.doi.org/10.1063/1.4973731 |
| _version_ | 1819057047678746624 |
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| author | Yaotian Liang Liwei Liu Siyi Hu Peng Zou Yue Wang Yingyi Liu Yu Ren Yulin Huang Sheng Ren |
| author_facet | Yaotian Liang Liwei Liu Siyi Hu Peng Zou Yue Wang Yingyi Liu Yu Ren Yulin Huang Sheng Ren |
| author_sort | Yaotian Liang |
| collection | DOAJ |
| description | Highly yield Cu2SnS3 nanocrystals (CTS NCs) have been attracted more attentions in these years, the CTS NCs with strong absorption in near-infrared (NIR) region which can serve as the contrast agent of Optical Coherence Tomography (OCT) imaging. These NCs can be synthesized by facile method, and exhibit a Localized Surface Plasmon Resonance (LSPR) peak in NIR region. The LSPR peak position of the CTS NCs depends on the ratio of copper to tin in the synthesis process. The highest intensity of LSPR at 1380nm when Cu:Sn ratio reach to 9:1. The TEM analysis and X-ray diffraction pattern reveals the formation of CTS NCs with an average size of 6nm and the structure is kesterite crystal phase. In order to apply the NCs in vivo and in vitro study, we used PEGylated phospholipid (DSPE-PEG) to modified NCs, and the colloidal stability and cell viability of DSPE-PEG CTS NCs are very suitable for the in vivo OCT imaging study. To quantitatively analyze the contrast effect of DSPE-PEG CTS NCs, the contrast agent was injected from the tail vein of ICR mice, then applied the SD-OCT system monitor the vein of the mouse pinna for 30 minutes. The results indicated that the DSPE-PEG CTS NCs created an obvious signal in the OCT imaging process, which provide the basis for the application of CTS NCs as the contrast agent for the bioimaging study. |
| first_indexed | 2024-12-21T13:33:06Z |
| format | Article |
| id | doaj.art-46f1a584a3e04f39915dad8dda4c20f3 |
| institution | Directory Open Access Journal |
| issn | 2158-3226 |
| language | English |
| last_indexed | 2024-12-21T13:33:06Z |
| publishDate | 2017-01-01 |
| publisher | AIP Publishing LLC |
| record_format | Article |
| series | AIP Advances |
| spelling | doaj.art-46f1a584a3e04f39915dad8dda4c20f32022-12-21T19:02:15ZengAIP Publishing LLCAIP Advances2158-32262017-01-0171015012015012-810.1063/1.4973731009701ADVCharacterizing physical properties and in vivo OCT imaging study of Cu-Sn-S nanocrystalsYaotian Liang0Liwei Liu1Siyi Hu2Peng Zou3Yue Wang4Yingyi Liu5Yu Ren6Yulin Huang7Sheng Ren8School of Science, Changchun University of Science and Technology, Changchun, Jilin, 130022, People’s Republic of ChinaSchool of Science, Changchun University of Science and Technology, Changchun, Jilin, 130022, People’s Republic of ChinaSchool of Science, Changchun University of Science and Technology, Changchun, Jilin, 130022, People’s Republic of ChinaSchool of Science, Changchun University of Science and Technology, Changchun, Jilin, 130022, People’s Republic of ChinaSchool of Science, Changchun University of Science and Technology, Changchun, Jilin, 130022, People’s Republic of ChinaSchool of Science, Changchun University of Science and Technology, Changchun, Jilin, 130022, People’s Republic of ChinaSchool of Science, Changchun University of Science and Technology, Changchun, Jilin, 130022, People’s Republic of ChinaSchool of Science, Changchun University of Science and Technology, Changchun, Jilin, 130022, People’s Republic of ChinaSchool of Science, Changchun University of Science and Technology, Changchun, Jilin, 130022, People’s Republic of ChinaHighly yield Cu2SnS3 nanocrystals (CTS NCs) have been attracted more attentions in these years, the CTS NCs with strong absorption in near-infrared (NIR) region which can serve as the contrast agent of Optical Coherence Tomography (OCT) imaging. These NCs can be synthesized by facile method, and exhibit a Localized Surface Plasmon Resonance (LSPR) peak in NIR region. The LSPR peak position of the CTS NCs depends on the ratio of copper to tin in the synthesis process. The highest intensity of LSPR at 1380nm when Cu:Sn ratio reach to 9:1. The TEM analysis and X-ray diffraction pattern reveals the formation of CTS NCs with an average size of 6nm and the structure is kesterite crystal phase. In order to apply the NCs in vivo and in vitro study, we used PEGylated phospholipid (DSPE-PEG) to modified NCs, and the colloidal stability and cell viability of DSPE-PEG CTS NCs are very suitable for the in vivo OCT imaging study. To quantitatively analyze the contrast effect of DSPE-PEG CTS NCs, the contrast agent was injected from the tail vein of ICR mice, then applied the SD-OCT system monitor the vein of the mouse pinna for 30 minutes. The results indicated that the DSPE-PEG CTS NCs created an obvious signal in the OCT imaging process, which provide the basis for the application of CTS NCs as the contrast agent for the bioimaging study.http://dx.doi.org/10.1063/1.4973731 |
| spellingShingle | Yaotian Liang Liwei Liu Siyi Hu Peng Zou Yue Wang Yingyi Liu Yu Ren Yulin Huang Sheng Ren Characterizing physical properties and in vivo OCT imaging study of Cu-Sn-S nanocrystals AIP Advances |
| title | Characterizing physical properties and in vivo OCT imaging study of Cu-Sn-S nanocrystals |
| title_full | Characterizing physical properties and in vivo OCT imaging study of Cu-Sn-S nanocrystals |
| title_fullStr | Characterizing physical properties and in vivo OCT imaging study of Cu-Sn-S nanocrystals |
| title_full_unstemmed | Characterizing physical properties and in vivo OCT imaging study of Cu-Sn-S nanocrystals |
| title_short | Characterizing physical properties and in vivo OCT imaging study of Cu-Sn-S nanocrystals |
| title_sort | characterizing physical properties and in vivo oct imaging study of cu sn s nanocrystals |
| url | http://dx.doi.org/10.1063/1.4973731 |
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