Biofabrication of gold and silver nanoparticles for pharmaceutical applications
Biofabrication by using fungi is an exciting recent interest to develop an eco-friendly production of metallic nanoparticles (NPs) for pharmaceutical applications. This study aimed to synthesize and characterize gold (Au) and silver (Ag) NPs by using Penicillium simplisimum. The fungus was grown in...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2016-02-01
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| Series: | Pharmaceutical and Biomedical Research |
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| Online Access: | http://pbr.mazums.ac.ir/browse.php?a_code=A-10-51-2&slc_lang=en&sid=1 |
| _version_ | 1818041837982580736 |
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| author | Hamed Barabadi Soheila Honary |
| author_facet | Hamed Barabadi Soheila Honary |
| author_sort | Hamed Barabadi |
| collection | DOAJ |
| description | Biofabrication by using fungi is an exciting recent interest to develop an eco-friendly production of metallic nanoparticles (NPs) for pharmaceutical applications. This study aimed to synthesize and characterize gold (Au) and silver (Ag) NPs by using Penicillium simplisimum. The fungus was grown in fluid czapek dox broth on shaker at 28 ºC and 200 rpm for ten days. Then the supernatant was separated from the mycelia to convert HAuCl4 and AgNO3 solution into Au and Ag NPs separately. After 24 hours, synthesized Au and Ag NPs were characterized by using UV-Visible Spectroscopy as well as Photon Correlation spectroscopy (PCS) involves Polydispersity Index (PDI) and zeta potential. The UV-Visible Spectroscopy analysis revealed a plasmon bond peak around 533 nm and 400 nm suggesting formation of Au and Ag NPs, respectively. Furthermore, the PCS analysis showed an average diameter of 68 nm and 76 nm with PDI value of 0.2 and 0.23 for Au and Ag NPs, successively, which demonstrated that the nanoparticles formed with fairly well-defined dimensions and good monodispersity. Besides, a negative zeta potential were found for nanoparticles indicating their stability in the solution. The current approach suggests that the rapid synthesis of nanoparticles would be suitable for developing a green process for mass scale production. Besides, we believe that development of eco-friendly process for the formulation of metallic NPs is an important step in the field of application of nanotechnology and its optimization may make it a potential procedure for industrial production of NPs. |
| first_indexed | 2024-12-10T08:36:47Z |
| format | Article |
| id | doaj.art-46f38fe7c37244509cd3781f6c2632de |
| institution | Directory Open Access Journal |
| issn | 2423-4486 2423-4494 |
| language | English |
| last_indexed | 2024-12-10T08:36:47Z |
| publishDate | 2016-02-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Pharmaceutical and Biomedical Research |
| spelling | doaj.art-46f38fe7c37244509cd3781f6c2632de2022-12-22T01:55:56ZengMazandaran University of Medical SciencesPharmaceutical and Biomedical Research2423-44862423-44942016-02-012117Biofabrication of gold and silver nanoparticles for pharmaceutical applicationsHamed Barabadi0Soheila Honary1 Department of Pharmaceutics, Faculty of Pharmacy Mazandaran University of Medical Sciences, Sari, Iran Department of Pharmaceutics, Faculty of Pharmacy Mazandaran University of Medical Sciences, Sari, Iran Biofabrication by using fungi is an exciting recent interest to develop an eco-friendly production of metallic nanoparticles (NPs) for pharmaceutical applications. This study aimed to synthesize and characterize gold (Au) and silver (Ag) NPs by using Penicillium simplisimum. The fungus was grown in fluid czapek dox broth on shaker at 28 ºC and 200 rpm for ten days. Then the supernatant was separated from the mycelia to convert HAuCl4 and AgNO3 solution into Au and Ag NPs separately. After 24 hours, synthesized Au and Ag NPs were characterized by using UV-Visible Spectroscopy as well as Photon Correlation spectroscopy (PCS) involves Polydispersity Index (PDI) and zeta potential. The UV-Visible Spectroscopy analysis revealed a plasmon bond peak around 533 nm and 400 nm suggesting formation of Au and Ag NPs, respectively. Furthermore, the PCS analysis showed an average diameter of 68 nm and 76 nm with PDI value of 0.2 and 0.23 for Au and Ag NPs, successively, which demonstrated that the nanoparticles formed with fairly well-defined dimensions and good monodispersity. Besides, a negative zeta potential were found for nanoparticles indicating their stability in the solution. The current approach suggests that the rapid synthesis of nanoparticles would be suitable for developing a green process for mass scale production. Besides, we believe that development of eco-friendly process for the formulation of metallic NPs is an important step in the field of application of nanotechnology and its optimization may make it a potential procedure for industrial production of NPs.http://pbr.mazums.ac.ir/browse.php?a_code=A-10-51-2&slc_lang=en&sid=1Gold nanoparticles silver nanoparticles biofabrication particle size Penicillium simplisimum |
| spellingShingle | Hamed Barabadi Soheila Honary Biofabrication of gold and silver nanoparticles for pharmaceutical applications Pharmaceutical and Biomedical Research Gold nanoparticles silver nanoparticles biofabrication particle size Penicillium simplisimum |
| title | Biofabrication of gold and silver nanoparticles for pharmaceutical applications |
| title_full | Biofabrication of gold and silver nanoparticles for pharmaceutical applications |
| title_fullStr | Biofabrication of gold and silver nanoparticles for pharmaceutical applications |
| title_full_unstemmed | Biofabrication of gold and silver nanoparticles for pharmaceutical applications |
| title_short | Biofabrication of gold and silver nanoparticles for pharmaceutical applications |
| title_sort | biofabrication of gold and silver nanoparticles for pharmaceutical applications |
| topic | Gold nanoparticles silver nanoparticles biofabrication particle size Penicillium simplisimum |
| url | http://pbr.mazums.ac.ir/browse.php?a_code=A-10-51-2&slc_lang=en&sid=1 |
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