Development of gut microbiota during the first 2 years of life
Abstract Although development of microbiota in childhood has been linked to chronic immune-related conditions, early childhood determinants of microbiota development have not been fully elucidated. We used 16S rRNA sequencing to analyse faecal and saliva samples from 83 children at four time-points...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-13009-3 |
| _version_ | 1828727685803671552 |
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| author | Mona-Lisa Wernroth Sari Peura Anna M. Hedman Susanne Hetty Silvia Vicenzi Beatrice Kennedy Katja Fall Bodil Svennblad Ellika Andolf Göran Pershagen Jenny Theorell-Haglöw Diem Nguyen Sergi Sayols-Baixeras Koen F. Dekkers Stefan Bertilsson Catarina Almqvist Johan Dicksved Tove Fall |
| author_facet | Mona-Lisa Wernroth Sari Peura Anna M. Hedman Susanne Hetty Silvia Vicenzi Beatrice Kennedy Katja Fall Bodil Svennblad Ellika Andolf Göran Pershagen Jenny Theorell-Haglöw Diem Nguyen Sergi Sayols-Baixeras Koen F. Dekkers Stefan Bertilsson Catarina Almqvist Johan Dicksved Tove Fall |
| author_sort | Mona-Lisa Wernroth |
| collection | DOAJ |
| description | Abstract Although development of microbiota in childhood has been linked to chronic immune-related conditions, early childhood determinants of microbiota development have not been fully elucidated. We used 16S rRNA sequencing to analyse faecal and saliva samples from 83 children at four time-points during their first 2 years of life and from their mothers. Our findings confirm that gut microbiota in infants have low diversity and highlight that some properties are shared with the oral microbiota, although inter-individual differences are present. A considerable convergence in gut microbiota composition was noted across the first 2 years of life, towards a more diverse adult-like microbiota. Mode of delivery accounted for some of the inter-individual variation in early childhood, but with a pronounced attenuation over time. Our study extends previous research with further characterization of the major shift in gut microbiota composition during the first 2 years of life. |
| first_indexed | 2024-04-12T14:02:02Z |
| format | Article |
| id | doaj.art-46f6108bf62741a19eee1eb73c2bd1a7 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T14:02:02Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-46f6108bf62741a19eee1eb73c2bd1a72022-12-22T03:30:10ZengNature PortfolioScientific Reports2045-23222022-05-0112111310.1038/s41598-022-13009-3Development of gut microbiota during the first 2 years of lifeMona-Lisa Wernroth0Sari Peura1Anna M. Hedman2Susanne Hetty3Silvia Vicenzi4Beatrice Kennedy5Katja Fall6Bodil Svennblad7Ellika Andolf8Göran Pershagen9Jenny Theorell-Haglöw10Diem Nguyen11Sergi Sayols-Baixeras12Koen F. Dekkers13Stefan Bertilsson14Catarina Almqvist15Johan Dicksved16Tove Fall17Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala UniversityDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala UniversityDepartment of Medical Epidemiology and Biostatistics, Karolinska InstitutetDepartment of Medical Sciences, Clinical Diabetology and Metabolism, Uppsala UniversityDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala UniversityDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala UniversityClinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro UniversityDepartment of Surgical Sciences, Uppsala UniversityDepartment of Clinical Sciences, Division of Obstetrics and Gynaecology, Danderyd Hospital, Karolinska InstitutetInstitute of Environmental Medicine, Karolinska InstitutetDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala UniversityDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala UniversityDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala UniversityDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala UniversityDepartment of Aquatic Sciences and Assessment, Swedish University of Agricultural SciencesDepartment of Medical Epidemiology and Biostatistics, Karolinska InstitutetDepartment of Animal Nutrition and Management, Swedish University of Agricultural SciencesDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala UniversityAbstract Although development of microbiota in childhood has been linked to chronic immune-related conditions, early childhood determinants of microbiota development have not been fully elucidated. We used 16S rRNA sequencing to analyse faecal and saliva samples from 83 children at four time-points during their first 2 years of life and from their mothers. Our findings confirm that gut microbiota in infants have low diversity and highlight that some properties are shared with the oral microbiota, although inter-individual differences are present. A considerable convergence in gut microbiota composition was noted across the first 2 years of life, towards a more diverse adult-like microbiota. Mode of delivery accounted for some of the inter-individual variation in early childhood, but with a pronounced attenuation over time. Our study extends previous research with further characterization of the major shift in gut microbiota composition during the first 2 years of life.https://doi.org/10.1038/s41598-022-13009-3 |
| spellingShingle | Mona-Lisa Wernroth Sari Peura Anna M. Hedman Susanne Hetty Silvia Vicenzi Beatrice Kennedy Katja Fall Bodil Svennblad Ellika Andolf Göran Pershagen Jenny Theorell-Haglöw Diem Nguyen Sergi Sayols-Baixeras Koen F. Dekkers Stefan Bertilsson Catarina Almqvist Johan Dicksved Tove Fall Development of gut microbiota during the first 2 years of life Scientific Reports |
| title | Development of gut microbiota during the first 2 years of life |
| title_full | Development of gut microbiota during the first 2 years of life |
| title_fullStr | Development of gut microbiota during the first 2 years of life |
| title_full_unstemmed | Development of gut microbiota during the first 2 years of life |
| title_short | Development of gut microbiota during the first 2 years of life |
| title_sort | development of gut microbiota during the first 2 years of life |
| url | https://doi.org/10.1038/s41598-022-13009-3 |
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