Cutoff Value of Psoas Muscle Area as Reduced Muscle Mass and Its Association with Acute Pancreatitis in China
Hao Fu,1 Ping Li,2 Qianchao Xing,3 Hui Jiang,1 Hangshuo Sui4 1Nutrition Department, Affiliated Hospital of Chengde Medical University, Chengde, Heibei, People’s Republic of China; 2Gastroenterology, Affiliated Hospital of Chengde Medical University, Chengde, Heibei People’s Republic of China; 3Radio...
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Dove Medical Press
2023-06-01
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| Series: | International Journal of General Medicine |
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| Online Access: | https://www.dovepress.com/cutoff-value-of-psoas-muscle-area-as-reduced-muscle-mass-and-its-assoc-peer-reviewed-fulltext-article-IJGM |
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| author | Fu H Li P Xing Q Jiang H Sui H |
| author_facet | Fu H Li P Xing Q Jiang H Sui H |
| author_sort | Fu H |
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| description | Hao Fu,1 Ping Li,2 Qianchao Xing,3 Hui Jiang,1 Hangshuo Sui4 1Nutrition Department, Affiliated Hospital of Chengde Medical University, Chengde, Heibei, People’s Republic of China; 2Gastroenterology, Affiliated Hospital of Chengde Medical University, Chengde, Heibei People’s Republic of China; 3Radiology Department, Affiliated Hospital of Chengde Medical University, Chengde, Heibei, People’s Republic of China; 4Nutrition Department, Chengde Central Hospital, Chengde, Heibei, People’s Republic of ChinaCorrespondence: Hangshuo Sui, Nutrition Department, Chengde Central Hospital, No. 11, Guangren Street, Chengde, Heibei, 067000, People’s Republic of China, Tel +86 0314 2028780, Email xyjw05@cdmc.edu.cnObjective: The Global Leadership Initiative on Malnutrition (GLIM) has proposed criteria for the diagnosis of malnutrition, one of which is reduced muscle mass. Computed tomography (CT) assessment of psoas muscle area (PMA) has been used to estimate muscle mass in patients, including those with acute pancreatitis (AP). The present study aimed to define the cutoff value of PMA indicative of reduced muscle mass in patients with AP and to assess the impact of reduced muscle mass on the severity and early complications of AP.Methods: Clinical data of 269 patients with AP were analyzed retrospectively. The severity of AP was determined according to the revised Atlanta classification. PMA was evaluated by CT and used to calculate the psoas muscle index (PMI). Cutoff values for reduced muscle mass were calculated and validated. Logistic regression analysis was performed to assess the relationship between PMA and the severity of AP.Results: PMA was a better indicator of reduced muscle mass than PMI, with cutoff values of 11.50 cm2 for men and 8.22 cm2 for women. Rates of local complications, splenic vein thrombosis, and organ failure were significantly higher in AP patients with low than high PMA (all p < 0.05). PMA showed good ability to predict splenic vein thrombosis in women, with an area under the receiver operating characteristic curve of 0.848 (95% confidence interval 0.768– 0.909, sensitivity 100%, specificity 83.64%). Multivariate logistic regression revealed that PMA was an independent risk factor for moderately severe plus severe AP (odds ratio 5.639, p = 0.001) and severe AP (odds ratio 3.995, p = 0.038).Conclusion: PMA is a good predictor of the severity and complications of AP. The PMA cutoff value is a good indicator of reduced muscle mass.Keywords: acute pancreatitis, psoas muscles, sarcopenia, malnutrition, cutoff value |
| first_indexed | 2024-03-13T01:49:25Z |
| format | Article |
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| language | English |
| last_indexed | 2024-03-13T01:49:25Z |
| publishDate | 2023-06-01 |
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| series | International Journal of General Medicine |
| spelling | doaj.art-46f72ce61b10491faffb8550ac9d9abb2023-07-02T19:49:18ZengDove Medical PressInternational Journal of General Medicine1178-70742023-06-01Volume 162733275184825Cutoff Value of Psoas Muscle Area as Reduced Muscle Mass and Its Association with Acute Pancreatitis in ChinaFu HLi PXing QJiang HSui HHao Fu,1 Ping Li,2 Qianchao Xing,3 Hui Jiang,1 Hangshuo Sui4 1Nutrition Department, Affiliated Hospital of Chengde Medical University, Chengde, Heibei, People’s Republic of China; 2Gastroenterology, Affiliated Hospital of Chengde Medical University, Chengde, Heibei People’s Republic of China; 3Radiology Department, Affiliated Hospital of Chengde Medical University, Chengde, Heibei, People’s Republic of China; 4Nutrition Department, Chengde Central Hospital, Chengde, Heibei, People’s Republic of ChinaCorrespondence: Hangshuo Sui, Nutrition Department, Chengde Central Hospital, No. 11, Guangren Street, Chengde, Heibei, 067000, People’s Republic of China, Tel +86 0314 2028780, Email xyjw05@cdmc.edu.cnObjective: The Global Leadership Initiative on Malnutrition (GLIM) has proposed criteria for the diagnosis of malnutrition, one of which is reduced muscle mass. Computed tomography (CT) assessment of psoas muscle area (PMA) has been used to estimate muscle mass in patients, including those with acute pancreatitis (AP). The present study aimed to define the cutoff value of PMA indicative of reduced muscle mass in patients with AP and to assess the impact of reduced muscle mass on the severity and early complications of AP.Methods: Clinical data of 269 patients with AP were analyzed retrospectively. The severity of AP was determined according to the revised Atlanta classification. PMA was evaluated by CT and used to calculate the psoas muscle index (PMI). Cutoff values for reduced muscle mass were calculated and validated. Logistic regression analysis was performed to assess the relationship between PMA and the severity of AP.Results: PMA was a better indicator of reduced muscle mass than PMI, with cutoff values of 11.50 cm2 for men and 8.22 cm2 for women. Rates of local complications, splenic vein thrombosis, and organ failure were significantly higher in AP patients with low than high PMA (all p < 0.05). PMA showed good ability to predict splenic vein thrombosis in women, with an area under the receiver operating characteristic curve of 0.848 (95% confidence interval 0.768– 0.909, sensitivity 100%, specificity 83.64%). Multivariate logistic regression revealed that PMA was an independent risk factor for moderately severe plus severe AP (odds ratio 5.639, p = 0.001) and severe AP (odds ratio 3.995, p = 0.038).Conclusion: PMA is a good predictor of the severity and complications of AP. The PMA cutoff value is a good indicator of reduced muscle mass.Keywords: acute pancreatitis, psoas muscles, sarcopenia, malnutrition, cutoff valuehttps://www.dovepress.com/cutoff-value-of-psoas-muscle-area-as-reduced-muscle-mass-and-its-assoc-peer-reviewed-fulltext-article-IJGMacute pancreatitispsoas musclessarcopeniamalnutritioncutoff value |
| spellingShingle | Fu H Li P Xing Q Jiang H Sui H Cutoff Value of Psoas Muscle Area as Reduced Muscle Mass and Its Association with Acute Pancreatitis in China International Journal of General Medicine acute pancreatitis psoas muscles sarcopenia malnutrition cutoff value |
| title | Cutoff Value of Psoas Muscle Area as Reduced Muscle Mass and Its Association with Acute Pancreatitis in China |
| title_full | Cutoff Value of Psoas Muscle Area as Reduced Muscle Mass and Its Association with Acute Pancreatitis in China |
| title_fullStr | Cutoff Value of Psoas Muscle Area as Reduced Muscle Mass and Its Association with Acute Pancreatitis in China |
| title_full_unstemmed | Cutoff Value of Psoas Muscle Area as Reduced Muscle Mass and Its Association with Acute Pancreatitis in China |
| title_short | Cutoff Value of Psoas Muscle Area as Reduced Muscle Mass and Its Association with Acute Pancreatitis in China |
| title_sort | cutoff value of psoas muscle area as reduced muscle mass and its association with acute pancreatitis in china |
| topic | acute pancreatitis psoas muscles sarcopenia malnutrition cutoff value |
| url | https://www.dovepress.com/cutoff-value-of-psoas-muscle-area-as-reduced-muscle-mass-and-its-assoc-peer-reviewed-fulltext-article-IJGM |
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