The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions

The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions

Neutrophils are the predominant immune cells in human blood possessing heterogeneity, plasticity and functional diversity. The activation and recruitment of neutrophils into inflamed tissue in response to stimuli are tightly regulated processes. Alpha1-Antitrypsin (AAT), an acute phase protein, is o...

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Bibliographic Details
Main Authors: Sabina Janciauskiene, Sabine Wrenger, Stephan Immenschuh, Beata Olejnicka, Timm Greulich, Tobias Welte, Joanna Chorostowska-Wynimko
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Pharmacology
Subjects:
neutrophil granulocyte
Alpha1-Antitrypsin
acute phase protein
innate immunity
inflammation
proteases
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00341/full
Description
Summary:Neutrophils are the predominant immune cells in human blood possessing heterogeneity, plasticity and functional diversity. The activation and recruitment of neutrophils into inflamed tissue in response to stimuli are tightly regulated processes. Alpha1-Antitrypsin (AAT), an acute phase protein, is one of the potent regulators of neutrophil activation via both -protease inhibitory and non-inhibitory functions. This review summarizes our current understanding of the effects of AAT on neutrophils, illustrating the interplay between AAT and the key effector functions of neutrophils.
ISSN:1663-9812

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