The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions
Neutrophils are the predominant immune cells in human blood possessing heterogeneity, plasticity and functional diversity. The activation and recruitment of neutrophils into inflamed tissue in response to stimuli are tightly regulated processes. Alpha1-Antitrypsin (AAT), an acute phase protein, is o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fphar.2018.00341/full |
| _version_ | 1811202360836358144 |
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| author | Sabina Janciauskiene Sabina Janciauskiene Sabine Wrenger Stephan Immenschuh Beata Olejnicka Timm Greulich Tobias Welte Joanna Chorostowska-Wynimko |
| author_facet | Sabina Janciauskiene Sabina Janciauskiene Sabine Wrenger Stephan Immenschuh Beata Olejnicka Timm Greulich Tobias Welte Joanna Chorostowska-Wynimko |
| author_sort | Sabina Janciauskiene |
| collection | DOAJ |
| description | Neutrophils are the predominant immune cells in human blood possessing heterogeneity, plasticity and functional diversity. The activation and recruitment of neutrophils into inflamed tissue in response to stimuli are tightly regulated processes. Alpha1-Antitrypsin (AAT), an acute phase protein, is one of the potent regulators of neutrophil activation via both -protease inhibitory and non-inhibitory functions. This review summarizes our current understanding of the effects of AAT on neutrophils, illustrating the interplay between AAT and the key effector functions of neutrophils. |
| first_indexed | 2024-04-12T02:37:30Z |
| format | Article |
| id | doaj.art-46f72fbd0aaf451b9001057f1e34c495 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-12T02:37:30Z |
| publishDate | 2018-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-46f72fbd0aaf451b9001057f1e34c4952022-12-22T03:51:27ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-04-01910.3389/fphar.2018.00341333492The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil FunctionsSabina Janciauskiene0Sabina Janciauskiene1Sabine Wrenger2Stephan Immenschuh3Beata Olejnicka4Timm Greulich5Tobias Welte6Joanna Chorostowska-Wynimko7Department of Respiratory Medicine, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover Medical School, Hannover, GermanyDepartment of Genetics and Clinical Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, PolandDepartment of Respiratory Medicine, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover Medical School, Hannover, GermanyInstitute for Transfusion Medicine, Hannover Medical School, Hannover, GermanyDepartment of Medicine, Trelleborg Hospital, Trelleborg, SwedenDepartment of Medicine, Pulmonary and Critical Care Medicine, Member of the German Center for Lung Research (DZL), University Hospital of Giessen and Marburg, University of Marburg, Marburg, GermanyDepartment of Respiratory Medicine, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover Medical School, Hannover, GermanyDepartment of Genetics and Clinical Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, PolandNeutrophils are the predominant immune cells in human blood possessing heterogeneity, plasticity and functional diversity. The activation and recruitment of neutrophils into inflamed tissue in response to stimuli are tightly regulated processes. Alpha1-Antitrypsin (AAT), an acute phase protein, is one of the potent regulators of neutrophil activation via both -protease inhibitory and non-inhibitory functions. This review summarizes our current understanding of the effects of AAT on neutrophils, illustrating the interplay between AAT and the key effector functions of neutrophils.http://journal.frontiersin.org/article/10.3389/fphar.2018.00341/fullneutrophil granulocyteAlpha1-Antitrypsinacute phase proteininnate immunityinflammationproteases |
| spellingShingle | Sabina Janciauskiene Sabina Janciauskiene Sabine Wrenger Stephan Immenschuh Beata Olejnicka Timm Greulich Tobias Welte Joanna Chorostowska-Wynimko The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions Frontiers in Pharmacology neutrophil granulocyte Alpha1-Antitrypsin acute phase protein innate immunity inflammation proteases |
| title | The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions |
| title_full | The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions |
| title_fullStr | The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions |
| title_full_unstemmed | The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions |
| title_short | The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions |
| title_sort | multifaceted effects of alpha1 antitrypsin on neutrophil functions |
| topic | neutrophil granulocyte Alpha1-Antitrypsin acute phase protein innate immunity inflammation proteases |
| url | http://journal.frontiersin.org/article/10.3389/fphar.2018.00341/full |
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