Effect on adherence to nicotine replacement therapy of informing smokers their dose is determined by their genotype: a randomised controlled trial.
The behavioural impact of pharmacogenomics is untested. We tested two hypotheses concerning the behavioural impact of informing smokers their oral dose of NRT is tailored to analysis of DNA.We conducted an RCT with smokers in smoking cessation clinics (N = 633). In combination with NRT patch, partic...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3324463?pdf=render |
| _version_ | 1830508863988695040 |
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| author | Theresa M Marteau Paul Aveyard Marcus R Munafò A Toby Prevost Gareth J Hollands David Armstrong Stephen Sutton Chloe Hill Elaine Johnstone Ann Louise Kinmonth |
| author_facet | Theresa M Marteau Paul Aveyard Marcus R Munafò A Toby Prevost Gareth J Hollands David Armstrong Stephen Sutton Chloe Hill Elaine Johnstone Ann Louise Kinmonth |
| author_sort | Theresa M Marteau |
| collection | DOAJ |
| description | The behavioural impact of pharmacogenomics is untested. We tested two hypotheses concerning the behavioural impact of informing smokers their oral dose of NRT is tailored to analysis of DNA.We conducted an RCT with smokers in smoking cessation clinics (N = 633). In combination with NRT patch, participants were informed that their doses of oral NRT were based either on their mu-opioid receptor (OPRM1) genotype, or their nicotine dependence questionnaire score (phenotype). The proportion of prescribed NRT consumed in the first 28 days following quitting was not significantly different between groups: (68.5% of prescribed NRT consumed in genotype vs 63.6%, phenotype group, difference = 5.0%, 95% CI -0.9,10.8, p = 0.098). Motivation to make another quit attempt among those (n = 331) not abstinent at six months was not significantly different between groups (p = 0.23). Abstinence at 28 days was not different between groups (p = 0.67); at six months was greater in genotype than phenotype group (13.7% vs 7.9%, difference = 5.8%, 95% CI 1.0,10.7, p = 0.018).Informing smokers their oral dose of NRT was tailored to genotype not phenotype had a small, statistically non-significant effect on 28-day adherence to NRT. Among those still smoking at six months, there was no evidence that saying NRT was tailored to genotype adversely affected motivation to make another quit attempt. Higher abstinence rate at six months in the genotype arm requires investigation.Controlled-Trials.com ISRCTN14352545. |
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| format | Article |
| id | doaj.art-46f873e99fe345c99b79f912e96eb46f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T01:25:32Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-46f873e99fe345c99b79f912e96eb46f2022-12-21T18:43:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0174e3524910.1371/journal.pone.0035249Effect on adherence to nicotine replacement therapy of informing smokers their dose is determined by their genotype: a randomised controlled trial.Theresa M MarteauPaul AveyardMarcus R MunafòA Toby PrevostGareth J HollandsDavid ArmstrongStephen SuttonChloe HillElaine JohnstoneAnn Louise KinmonthThe behavioural impact of pharmacogenomics is untested. We tested two hypotheses concerning the behavioural impact of informing smokers their oral dose of NRT is tailored to analysis of DNA.We conducted an RCT with smokers in smoking cessation clinics (N = 633). In combination with NRT patch, participants were informed that their doses of oral NRT were based either on their mu-opioid receptor (OPRM1) genotype, or their nicotine dependence questionnaire score (phenotype). The proportion of prescribed NRT consumed in the first 28 days following quitting was not significantly different between groups: (68.5% of prescribed NRT consumed in genotype vs 63.6%, phenotype group, difference = 5.0%, 95% CI -0.9,10.8, p = 0.098). Motivation to make another quit attempt among those (n = 331) not abstinent at six months was not significantly different between groups (p = 0.23). Abstinence at 28 days was not different between groups (p = 0.67); at six months was greater in genotype than phenotype group (13.7% vs 7.9%, difference = 5.8%, 95% CI 1.0,10.7, p = 0.018).Informing smokers their oral dose of NRT was tailored to genotype not phenotype had a small, statistically non-significant effect on 28-day adherence to NRT. Among those still smoking at six months, there was no evidence that saying NRT was tailored to genotype adversely affected motivation to make another quit attempt. Higher abstinence rate at six months in the genotype arm requires investigation.Controlled-Trials.com ISRCTN14352545.http://europepmc.org/articles/PMC3324463?pdf=render |
| spellingShingle | Theresa M Marteau Paul Aveyard Marcus R Munafò A Toby Prevost Gareth J Hollands David Armstrong Stephen Sutton Chloe Hill Elaine Johnstone Ann Louise Kinmonth Effect on adherence to nicotine replacement therapy of informing smokers their dose is determined by their genotype: a randomised controlled trial. PLoS ONE |
| title | Effect on adherence to nicotine replacement therapy of informing smokers their dose is determined by their genotype: a randomised controlled trial. |
| title_full | Effect on adherence to nicotine replacement therapy of informing smokers their dose is determined by their genotype: a randomised controlled trial. |
| title_fullStr | Effect on adherence to nicotine replacement therapy of informing smokers their dose is determined by their genotype: a randomised controlled trial. |
| title_full_unstemmed | Effect on adherence to nicotine replacement therapy of informing smokers their dose is determined by their genotype: a randomised controlled trial. |
| title_short | Effect on adherence to nicotine replacement therapy of informing smokers their dose is determined by their genotype: a randomised controlled trial. |
| title_sort | effect on adherence to nicotine replacement therapy of informing smokers their dose is determined by their genotype a randomised controlled trial |
| url | http://europepmc.org/articles/PMC3324463?pdf=render |
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