The association between air pollution and the severity at diagnosis and progression of systemic sclerosis-associated interstitial lung disease: results from the retrospective ScleroPol study
Abstract Objective To investigate the association of air pollution exposure with the severity of interstitial lung disease (ILD) at diagnosis and ILD progression among patients with systemic sclerosis (SSc)-associated ILD. Methods We conducted a retrospective two-center study of patients with SSc-as...
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12931-023-02463-w |
| _version_ | 1797806567361347584 |
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| author | Anaïs Roeser Lucile Sese Guillaume Chassagnon Benjamin Chaigne Bertrand Dunogue Stéphane Tran Ba Salma Jebri Pierre-Yves Brillet Marie Pierre Revel Frédérique Aubourg Robin Dhote Frédéric Caux Isabella Annesi-Maesano Luc Mouthon Hilario Nunes Yurdagül Uzunhan |
| author_facet | Anaïs Roeser Lucile Sese Guillaume Chassagnon Benjamin Chaigne Bertrand Dunogue Stéphane Tran Ba Salma Jebri Pierre-Yves Brillet Marie Pierre Revel Frédérique Aubourg Robin Dhote Frédéric Caux Isabella Annesi-Maesano Luc Mouthon Hilario Nunes Yurdagül Uzunhan |
| author_sort | Anaïs Roeser |
| collection | DOAJ |
| description | Abstract Objective To investigate the association of air pollution exposure with the severity of interstitial lung disease (ILD) at diagnosis and ILD progression among patients with systemic sclerosis (SSc)-associated ILD. Methods We conducted a retrospective two-center study of patients with SSc-associated ILD diagnosed between 2006 and 2019. Exposure to the air pollutants particulate matter of up to 10 and 2.5 µm in diameter (PM10, PM2.5), nitrogen dioxide (NO2), and ozone (O3) was assessed at the geolocalization coordinates of the patients’ residential address. Logistic regression models were used to evaluate the association between air pollution and severity at diagnosis according to the Goh staging algorithm, and progression at 12 and 24 months. Results We included 181 patients, 80% of whom were women; 44% had diffuse cutaneous scleroderma, and 56% had anti-topoisomerase I antibodies. ILD was extensive, according to the Goh staging algorithm, in 29% of patients. O3 exposure was associated with the presence of extensive ILD at diagnosis (adjusted OR: 1.12, 95% CI 1.05–1.21; p value = 0.002). At 12 and 24 months, progression was noted in 27/105 (26%) and 48/113 (43%) patients, respectively. O3 exposure was associated with progression at 24 months (adjusted OR: 1.10, 95% CI 1.02–1.19; p value = 0.02). We found no association between exposure to other air pollutants and severity at diagnosis and progression. Conclusion Our findings suggest that high levels of O3 exposure are associated with more severe SSc-associated ILD at diagnosis, and progression at 24 months. |
| first_indexed | 2024-03-13T06:09:13Z |
| format | Article |
| id | doaj.art-46f9929ac5fb4a8293aeb88fce31d0ca |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-03-13T06:09:13Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-46f9929ac5fb4a8293aeb88fce31d0ca2023-06-11T11:23:15ZengBMCRespiratory Research1465-993X2023-06-0124111310.1186/s12931-023-02463-wThe association between air pollution and the severity at diagnosis and progression of systemic sclerosis-associated interstitial lung disease: results from the retrospective ScleroPol studyAnaïs Roeser0Lucile Sese1Guillaume Chassagnon2Benjamin Chaigne3Bertrand Dunogue4Stéphane Tran Ba5Salma Jebri6Pierre-Yves Brillet7Marie Pierre Revel8Frédérique Aubourg9Robin Dhote10Frédéric Caux11Isabella Annesi-Maesano12Luc Mouthon13Hilario Nunes14Yurdagül Uzunhan15Department of Pulmonology, Assistance Publique-Hôpitaux de Paris (APHP), Avicenne HospitalDepartment of Pulmonology, Assistance Publique-Hôpitaux de Paris (APHP), Avicenne HospitalDepartment of Radiology A, Assistance Publique-Hôpitaux de Paris (APHP), Cochin HospitalDepartment of Internal Medicine, Assistance Publique-Hôpitaux de Paris (APHP), Cochin HospitalDepartment of Internal Medicine, Assistance Publique-Hôpitaux de Paris (APHP), Cochin HospitalDepartment of Radiology, Assistance Publique-Hôpitaux de Paris (APHP), Avicenne HospitalDepartment of Radiology, Assistance Publique-Hôpitaux de Paris (APHP), Avicenne HospitalDepartment of Radiology, Assistance Publique-Hôpitaux de Paris (APHP), Avicenne HospitalDepartment of Radiology A, Assistance Publique-Hôpitaux de Paris (APHP), Cochin HospitalDepartment of Physiology, Assistance Publique-Hôpitaux de Paris (APHP), Cochin HospitalDepartment of Internal Medicine, Assistance Publique-Hôpitaux de Paris (APHP), Avicenne HospitalDepartment of Dermatology, Assistance Publique-Hôpitaux de Paris (APHP), Avicenne HospitalINSERM, Department of Allergic and Respiratory Disease, Montpellier University Hospital, Institute Desbrest of Epidemiology and Public Health, University of MontpellierDepartment of Internal Medicine, Assistance Publique-Hôpitaux de Paris (APHP), Cochin HospitalDepartment of Pulmonology, Assistance Publique-Hôpitaux de Paris (APHP), Avicenne HospitalDepartment of Pulmonology, Assistance Publique-Hôpitaux de Paris (APHP), Avicenne HospitalAbstract Objective To investigate the association of air pollution exposure with the severity of interstitial lung disease (ILD) at diagnosis and ILD progression among patients with systemic sclerosis (SSc)-associated ILD. Methods We conducted a retrospective two-center study of patients with SSc-associated ILD diagnosed between 2006 and 2019. Exposure to the air pollutants particulate matter of up to 10 and 2.5 µm in diameter (PM10, PM2.5), nitrogen dioxide (NO2), and ozone (O3) was assessed at the geolocalization coordinates of the patients’ residential address. Logistic regression models were used to evaluate the association between air pollution and severity at diagnosis according to the Goh staging algorithm, and progression at 12 and 24 months. Results We included 181 patients, 80% of whom were women; 44% had diffuse cutaneous scleroderma, and 56% had anti-topoisomerase I antibodies. ILD was extensive, according to the Goh staging algorithm, in 29% of patients. O3 exposure was associated with the presence of extensive ILD at diagnosis (adjusted OR: 1.12, 95% CI 1.05–1.21; p value = 0.002). At 12 and 24 months, progression was noted in 27/105 (26%) and 48/113 (43%) patients, respectively. O3 exposure was associated with progression at 24 months (adjusted OR: 1.10, 95% CI 1.02–1.19; p value = 0.02). We found no association between exposure to other air pollutants and severity at diagnosis and progression. Conclusion Our findings suggest that high levels of O3 exposure are associated with more severe SSc-associated ILD at diagnosis, and progression at 24 months.https://doi.org/10.1186/s12931-023-02463-wSystemic sclerosisSclerodermaInterstitial lung diseaseAir pollutionOzoneParticulate matter |
| spellingShingle | Anaïs Roeser Lucile Sese Guillaume Chassagnon Benjamin Chaigne Bertrand Dunogue Stéphane Tran Ba Salma Jebri Pierre-Yves Brillet Marie Pierre Revel Frédérique Aubourg Robin Dhote Frédéric Caux Isabella Annesi-Maesano Luc Mouthon Hilario Nunes Yurdagül Uzunhan The association between air pollution and the severity at diagnosis and progression of systemic sclerosis-associated interstitial lung disease: results from the retrospective ScleroPol study Respiratory Research Systemic sclerosis Scleroderma Interstitial lung disease Air pollution Ozone Particulate matter |
| title | The association between air pollution and the severity at diagnosis and progression of systemic sclerosis-associated interstitial lung disease: results from the retrospective ScleroPol study |
| title_full | The association between air pollution and the severity at diagnosis and progression of systemic sclerosis-associated interstitial lung disease: results from the retrospective ScleroPol study |
| title_fullStr | The association between air pollution and the severity at diagnosis and progression of systemic sclerosis-associated interstitial lung disease: results from the retrospective ScleroPol study |
| title_full_unstemmed | The association between air pollution and the severity at diagnosis and progression of systemic sclerosis-associated interstitial lung disease: results from the retrospective ScleroPol study |
| title_short | The association between air pollution and the severity at diagnosis and progression of systemic sclerosis-associated interstitial lung disease: results from the retrospective ScleroPol study |
| title_sort | association between air pollution and the severity at diagnosis and progression of systemic sclerosis associated interstitial lung disease results from the retrospective scleropol study |
| topic | Systemic sclerosis Scleroderma Interstitial lung disease Air pollution Ozone Particulate matter |
| url | https://doi.org/10.1186/s12931-023-02463-w |
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