COPPER NANOPARTICLES FOR IONIZING RADIATION DOSIMETRY FORTHERANOSTICS
The present investigation is focused on the effect of copper nanoparticles infused in a PAGAT dosimetry system. Monte Carlo simulations using the PENELOPE code were employed to analyze a system composed of stabilized copper nanoparticles coated with ascorbic acid. The system was subjected to irradia...
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| Format: | Article |
| Language: | Spanish |
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CEILAP-UNIDEF-CONICET-CITEDEF
2023-09-01
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| Series: | Anales (Asociación Física Argentina) |
| Subjects: | |
| Online Access: | https://anales.fisica.org.ar/index.php/analesafa/article/view/2392/2923 |
| _version_ | 1797661638157926400 |
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| author | S. Lechón Páez G. Tubon Usca M. Valente F. Mattea |
| author_facet | S. Lechón Páez G. Tubon Usca M. Valente F. Mattea |
| author_sort | S. Lechón Páez |
| collection | DOAJ |
| description | The present investigation is focused on the effect of copper nanoparticles infused in a PAGAT dosimetry system. Monte Carlo simulations using the PENELOPE code were employed to analyze a system composed of stabilized copper nanoparticles coated with ascorbic acid. The system was subjected to irradiation with a 150 keV monoenergetic photon beam, representative of orthovoltage applications. The study evaluated the influence of three key factors: the size of the copper nanoparticle (ranging from 10 to 300 nm), the coating thickness (ranging from 25 to 400 nm), and the coating density (ranging from 1.162 to 1.650 g/mL). The findings indicate a slight increase in dose enhancement with increasingnanoparticle size. Conversely, an increase in stabilizer thickness leads to a decrease in dose enhancement in the PAGAT system. The effect of changes in stabilizer density on dose enhancement is found to be less significant. Additionally, the photon fluence spectrum was analyzed for the three studied cases to identify and evaluate the characteristic fluorescence lines of copper. This analysis confirms the presence of characteristic X-rays derived from the presence of copper nanoparticles, which could potentially serve as a foundation for specific imaging techniques. |
| first_indexed | 2024-03-11T18:48:05Z |
| format | Article |
| id | doaj.art-46fa9eae046e4ff1a4f3df0e893b1d97 |
| institution | Directory Open Access Journal |
| issn | 1850-1168 |
| language | Spanish |
| last_indexed | 2024-03-11T18:48:05Z |
| publishDate | 2023-09-01 |
| publisher | CEILAP-UNIDEF-CONICET-CITEDEF |
| record_format | Article |
| series | Anales (Asociación Física Argentina) |
| spelling | doaj.art-46fa9eae046e4ff1a4f3df0e893b1d972023-10-11T15:24:47ZspaCEILAP-UNIDEF-CONICET-CITEDEFAnales (Asociación Física Argentina)1850-11682023-09-013435564https://doi.org/10.31527/analesafa.2023.34.3.55COPPER NANOPARTICLES FOR IONIZING RADIATION DOSIMETRY FORTHERANOSTICSS. Lechón Páez0G. Tubon Usca1M. Valente2F. Mattea31Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada (IPQA), CONICET - Universidad Nacional deCórdoba, Córdoba, 5000, Argentina 2Laboratorio de Investigación e Instrumentación en Física Aplicada a la Medicina e Imágenes por Rayos X, LIIFAMIRx⃝, FAMAF,Universidad Nacional de Córdoba, Córdoba, 5000, Argentina3Grupo de Materiales Avanzados (GIMA), Ing. Química, Facultad de Ciencias, Escuela Superior Politécnica de Chimborazo,Riobamba, EC060155, Ecuador4Instituto de Física Enrique Gaviola (IFEG), CONICET, FAMAF, Universidad Nacional de Córdoba, Córdoba, 5000, Argentina 2Laboratorio de Investigación e Instrumentación en Física Aplicada a la Medicina e Imágenes por Rayos X, LIIFAMIRx⃝, FAMAF,Universidad Nacional de Córdoba, Córdoba, 5000, Argentina 5Centro de excelencia en Física e Ingeniería en Salud (CFIS) & Departamento de Ciencias Físicas, Universidad de la Frontera,Temuco, 4780000, Chile6Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, 5000, Argentina 1Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada (IPQA), CONICET - Universidad Nacional deCórdoba, Córdoba, 5000, Argentina 2Laboratorio de Investigación e Instrumentación en Física Aplicada a la Medicina e Imágenes por Rayos X, LIIFAMIRx⃝, FAMAF,Universidad Nacional de Córdoba, Córdoba, 5000, ArgentinaThe present investigation is focused on the effect of copper nanoparticles infused in a PAGAT dosimetry system. Monte Carlo simulations using the PENELOPE code were employed to analyze a system composed of stabilized copper nanoparticles coated with ascorbic acid. The system was subjected to irradiation with a 150 keV monoenergetic photon beam, representative of orthovoltage applications. The study evaluated the influence of three key factors: the size of the copper nanoparticle (ranging from 10 to 300 nm), the coating thickness (ranging from 25 to 400 nm), and the coating density (ranging from 1.162 to 1.650 g/mL). The findings indicate a slight increase in dose enhancement with increasingnanoparticle size. Conversely, an increase in stabilizer thickness leads to a decrease in dose enhancement in the PAGAT system. The effect of changes in stabilizer density on dose enhancement is found to be less significant. Additionally, the photon fluence spectrum was analyzed for the three studied cases to identify and evaluate the characteristic fluorescence lines of copper. This analysis confirms the presence of characteristic X-rays derived from the presence of copper nanoparticles, which could potentially serve as a foundation for specific imaging techniques.https://anales.fisica.org.ar/index.php/analesafa/article/view/2392/2923polymer gelnanoparticlestheranosticsmonte carlo simulations |
| spellingShingle | S. Lechón Páez G. Tubon Usca M. Valente F. Mattea COPPER NANOPARTICLES FOR IONIZING RADIATION DOSIMETRY FORTHERANOSTICS Anales (Asociación Física Argentina) polymer gel nanoparticles theranostics monte carlo simulations |
| title | COPPER NANOPARTICLES FOR IONIZING RADIATION DOSIMETRY FORTHERANOSTICS |
| title_full | COPPER NANOPARTICLES FOR IONIZING RADIATION DOSIMETRY FORTHERANOSTICS |
| title_fullStr | COPPER NANOPARTICLES FOR IONIZING RADIATION DOSIMETRY FORTHERANOSTICS |
| title_full_unstemmed | COPPER NANOPARTICLES FOR IONIZING RADIATION DOSIMETRY FORTHERANOSTICS |
| title_short | COPPER NANOPARTICLES FOR IONIZING RADIATION DOSIMETRY FORTHERANOSTICS |
| title_sort | copper nanoparticles for ionizing radiation dosimetry fortheranostics |
| topic | polymer gel nanoparticles theranostics monte carlo simulations |
| url | https://anales.fisica.org.ar/index.php/analesafa/article/view/2392/2923 |
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