Immobilization of Metronidazole on Mesoporous Silica Materials
Metronidazole (MTZ) is a widely used drug, but due to its many side effects, there is a growing trend today to use a minimum dose while maintaining high efficacy. One way to meet this demand is to reduce the size of the drug particles. A relatively new method of size reduction is attaching the drug...
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MDPI AG
2022-10-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/11/2332 |
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| author | Klára Szentmihályi Szilvia Klébert Zoltán May Eszter Bódis Miklós Mohai László Trif Tivadar Feczkó Zoltán Károly |
| author_facet | Klára Szentmihályi Szilvia Klébert Zoltán May Eszter Bódis Miklós Mohai László Trif Tivadar Feczkó Zoltán Károly |
| author_sort | Klára Szentmihályi |
| collection | DOAJ |
| description | Metronidazole (MTZ) is a widely used drug, but due to its many side effects, there is a growing trend today to use a minimum dose while maintaining high efficacy. One way to meet this demand is to reduce the size of the drug particles. A relatively new method of size reduction is attaching the drug molecules to a mesoporous carrier. In this paper, we studied the fixation of MTZ molecules on mesoporous silica carriers. The drug was immobilized on two mesoporous silica materials (Syloid, SBA-15) with the use of a variety of immersion techniques and solvents. The immobilized drug was subjected to physicochemical examinations (e.g., SEM, XPS, XRD, nitrogen uptake, DSC) and dissolution studies. A significantly higher immobilization was attained on SBA-15 than on a Syloid carrier. Among the processing parameters, the type of MTZ solvent had the highest influence on immobilization. Ultrasonic agitation had a lower but still significant impact, while the concentration of MTZ in the solution made no difference. Under optimal conditions, with the application of an ethyl acetate solution, the surface coverage on SBA-15 reached as much as 91%. The immobilized MTZ exhibited a ca. 10% faster dissolution rate as compared to the pure micron-sized drug particles. |
| first_indexed | 2024-03-09T18:44:55Z |
| format | Article |
| id | doaj.art-46fc0ad7e18341898581bdf55b9d6889 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T18:44:55Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-46fc0ad7e18341898581bdf55b9d68892023-11-24T06:20:30ZengMDPI AGPharmaceutics1999-49232022-10-011411233210.3390/pharmaceutics14112332Immobilization of Metronidazole on Mesoporous Silica MaterialsKlára Szentmihályi0Szilvia Klébert1Zoltán May2Eszter Bódis3Miklós Mohai4László Trif5Tivadar Feczkó6Zoltán Károly7Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Magyar Tudósok Körútja 2, H-1117 Budapest, HungaryInstitute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Magyar Tudósok Körútja 2, H-1117 Budapest, HungaryInstitute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Magyar Tudósok Körútja 2, H-1117 Budapest, HungaryInstitute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Magyar Tudósok Körútja 2, H-1117 Budapest, HungaryInstitute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Magyar Tudósok Körútja 2, H-1117 Budapest, HungaryInstitute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Magyar Tudósok Körútja 2, H-1117 Budapest, HungaryInstitute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Magyar Tudósok Körútja 2, H-1117 Budapest, HungaryInstitute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Magyar Tudósok Körútja 2, H-1117 Budapest, HungaryMetronidazole (MTZ) is a widely used drug, but due to its many side effects, there is a growing trend today to use a minimum dose while maintaining high efficacy. One way to meet this demand is to reduce the size of the drug particles. A relatively new method of size reduction is attaching the drug molecules to a mesoporous carrier. In this paper, we studied the fixation of MTZ molecules on mesoporous silica carriers. The drug was immobilized on two mesoporous silica materials (Syloid, SBA-15) with the use of a variety of immersion techniques and solvents. The immobilized drug was subjected to physicochemical examinations (e.g., SEM, XPS, XRD, nitrogen uptake, DSC) and dissolution studies. A significantly higher immobilization was attained on SBA-15 than on a Syloid carrier. Among the processing parameters, the type of MTZ solvent had the highest influence on immobilization. Ultrasonic agitation had a lower but still significant impact, while the concentration of MTZ in the solution made no difference. Under optimal conditions, with the application of an ethyl acetate solution, the surface coverage on SBA-15 reached as much as 91%. The immobilized MTZ exhibited a ca. 10% faster dissolution rate as compared to the pure micron-sized drug particles.https://www.mdpi.com/1999-4923/14/11/2332metronidazolemesoporous silica materialSBA-15dissolution |
| spellingShingle | Klára Szentmihályi Szilvia Klébert Zoltán May Eszter Bódis Miklós Mohai László Trif Tivadar Feczkó Zoltán Károly Immobilization of Metronidazole on Mesoporous Silica Materials Pharmaceutics metronidazole mesoporous silica material SBA-15 dissolution |
| title | Immobilization of Metronidazole on Mesoporous Silica Materials |
| title_full | Immobilization of Metronidazole on Mesoporous Silica Materials |
| title_fullStr | Immobilization of Metronidazole on Mesoporous Silica Materials |
| title_full_unstemmed | Immobilization of Metronidazole on Mesoporous Silica Materials |
| title_short | Immobilization of Metronidazole on Mesoporous Silica Materials |
| title_sort | immobilization of metronidazole on mesoporous silica materials |
| topic | metronidazole mesoporous silica material SBA-15 dissolution |
| url | https://www.mdpi.com/1999-4923/14/11/2332 |
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