Association of maternal serum beta human chorionic gonadotropin (B-hCG) level with intrayterine growth restriction: a case control study
Introduction: Intrauterine growth restriction (IUGR) is a major cause of perinatal morbidity and mortality. The human chorionic gonadotropin (B-hCG) is suggested to be released in large amounts into the maternal circulation due to placental dysfunction. Studies have shown that raised levels of B-hCG...
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| Format: | Article |
| Language: | English |
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Khesar Gyalpo University of Medical Sciences of Bh
2019-05-01
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| Series: | Bhutan Health Journal |
| Online Access: | https://bhj.com.bt/index.php/bhj/article/view/74 |
| _version_ | 1797650125187710976 |
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| author | Yeshey Dorjey |
| author_facet | Yeshey Dorjey |
| author_sort | Yeshey Dorjey |
| collection | DOAJ |
| description | Introduction: Intrauterine growth restriction (IUGR) is a major cause of perinatal morbidity and mortality. The human chorionic gonadotropin (B-hCG) is suggested to be released in large amounts into the maternal circulation due to placental dysfunction. Studies have shown that raised levels of B-hCG was associated with IUGR in the first and second trimesters. However, no study was done during the third trimester. Therefore, the objective of the study was to determine the association of B-hCG level with IUGR during 3rd trimester.
Methods: A case-control one year-period study completed in the Department of Obstetrics and Gynaecology, BSMMU, Bangladesh. Pregnant mothers diagnosed with IUGR were taken as case (n=55) and mothers without IUGR as control (n=55). Serum B-hCG levels of these two groups were measured. The data was analysed with SPSS-16 software. Chi-square test was used for analysis.
Results: The mean estimated fetal weight (EFW) of case was significantly less as compared to control (p<0.001). Out of 55 pregnancies with IUGR, 14 (25.5%) had raised level of B-hCG as compared to only 4(7.3%) of control had raised B-hCG level. The odds ratio (OR) of developing IUGR in pregnant women with raised B-hCG level was found to be 4.4 fold (95% CI: 1.331- 14.237) higher than the pregnant women with normal level of B-hCG.
Conclusions: The study concluded a significant association between the raised levels of B-hCG with IUGR. |
| first_indexed | 2024-03-11T15:56:49Z |
| format | Article |
| id | doaj.art-46fc6b49632e4e8d9942fa8363909fcf |
| institution | Directory Open Access Journal |
| issn | 2413-2993 2415-1114 |
| language | English |
| last_indexed | 2024-03-11T15:56:49Z |
| publishDate | 2019-05-01 |
| publisher | Khesar Gyalpo University of Medical Sciences of Bh |
| record_format | Article |
| series | Bhutan Health Journal |
| spelling | doaj.art-46fc6b49632e4e8d9942fa8363909fcf2023-10-25T10:01:33ZengKhesar Gyalpo University of Medical Sciences of BhBhutan Health Journal2413-29932415-11142019-05-01511810.47811/bhj.110145Association of maternal serum beta human chorionic gonadotropin (B-hCG) level with intrayterine growth restriction: a case control studyYeshey Dorjey0https://orcid.org/0000-0001-7324-3028Phuentsholing General Hospital, Chukha, BhutanIntroduction: Intrauterine growth restriction (IUGR) is a major cause of perinatal morbidity and mortality. The human chorionic gonadotropin (B-hCG) is suggested to be released in large amounts into the maternal circulation due to placental dysfunction. Studies have shown that raised levels of B-hCG was associated with IUGR in the first and second trimesters. However, no study was done during the third trimester. Therefore, the objective of the study was to determine the association of B-hCG level with IUGR during 3rd trimester. Methods: A case-control one year-period study completed in the Department of Obstetrics and Gynaecology, BSMMU, Bangladesh. Pregnant mothers diagnosed with IUGR were taken as case (n=55) and mothers without IUGR as control (n=55). Serum B-hCG levels of these two groups were measured. The data was analysed with SPSS-16 software. Chi-square test was used for analysis. Results: The mean estimated fetal weight (EFW) of case was significantly less as compared to control (p<0.001). Out of 55 pregnancies with IUGR, 14 (25.5%) had raised level of B-hCG as compared to only 4(7.3%) of control had raised B-hCG level. The odds ratio (OR) of developing IUGR in pregnant women with raised B-hCG level was found to be 4.4 fold (95% CI: 1.331- 14.237) higher than the pregnant women with normal level of B-hCG. Conclusions: The study concluded a significant association between the raised levels of B-hCG with IUGR.https://bhj.com.bt/index.php/bhj/article/view/74 |
| spellingShingle | Yeshey Dorjey Association of maternal serum beta human chorionic gonadotropin (B-hCG) level with intrayterine growth restriction: a case control study Bhutan Health Journal |
| title | Association of maternal serum beta human chorionic gonadotropin (B-hCG) level with intrayterine growth restriction: a case control study |
| title_full | Association of maternal serum beta human chorionic gonadotropin (B-hCG) level with intrayterine growth restriction: a case control study |
| title_fullStr | Association of maternal serum beta human chorionic gonadotropin (B-hCG) level with intrayterine growth restriction: a case control study |
| title_full_unstemmed | Association of maternal serum beta human chorionic gonadotropin (B-hCG) level with intrayterine growth restriction: a case control study |
| title_short | Association of maternal serum beta human chorionic gonadotropin (B-hCG) level with intrayterine growth restriction: a case control study |
| title_sort | association of maternal serum beta human chorionic gonadotropin b hcg level with intrayterine growth restriction a case control study |
| url | https://bhj.com.bt/index.php/bhj/article/view/74 |
| work_keys_str_mv | AT yesheydorjey associationofmaternalserumbetahumanchorionicgonadotropinbhcglevelwithintrayterinegrowthrestrictionacasecontrolstudy |