Research Progress of Exosome-based Liquid Biopsy in Diagnosis of Pancreatic Cancer
Pancreatic cancer (PC) is a highly malignant tumor of the digestive system. Due to the lack of sensitive and effective detection markers, the tumor is usually at a relatively advanced stage in initial diagnosis. Therefore, early detection of PC is crucial for timely treatment and better prognosis. E...
| Main Authors: | , , |
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| Format: | Article |
| Language: | zho |
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Magazine House of Cancer Research on Prevention and Treatment
2022-03-01
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| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2022.21.1008 |
| _version_ | 1818307889914183680 |
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| author | GUO Madi ZHAO Juan HUANG Xiaoyi |
| author_facet | GUO Madi ZHAO Juan HUANG Xiaoyi |
| author_sort | GUO Madi |
| collection | DOAJ |
| description | Pancreatic cancer (PC) is a highly malignant tumor of the digestive system. Due to the lack of sensitive and effective detection markers, the tumor is usually at a relatively advanced stage in initial diagnosis. Therefore, early detection of PC is crucial for timely treatment and better prognosis. Exosomes are extracellular vesicles secreted by cells. They have a lipid bimolecular membrane structure to ensure the stable existence of a large number of biologically active substances contained therein. So they can accurately reflect the characteristics of parental cells. Exosomes are widely present in various body fluids and can non-invasively, conveniently and real-timely extracted, with the potential to become a marker for early tumor diagnosis. Previous studies have shown that compared with traditional diagnostic methods, exosomes showed higher sensitivity and specificity in the early diagnosis of various cancers. This article reviews the research progress of exosomes in the early diagnosis of pancreatic cancer. |
| first_indexed | 2024-12-13T07:05:33Z |
| format | Article |
| id | doaj.art-46ffd943e424471abe9d37417765f306 |
| institution | Directory Open Access Journal |
| issn | 1000-8578 |
| language | zho |
| last_indexed | 2024-12-13T07:05:33Z |
| publishDate | 2022-03-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-46ffd943e424471abe9d37417765f3062022-12-21T23:55:49ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782022-03-0149324024510.3971/j.issn.1000-8578.2022.21.10088578.2022.21.1008Research Progress of Exosome-based Liquid Biopsy in Diagnosis of Pancreatic CancerGUO Madi0ZHAO Juan1HUANG Xiaoyi2Biotherapy Center, Affiliated Tumor Hospital of Harbin Medical University, Harbin 150081, ChinaBiotherapy Center, Affiliated Tumor Hospital of Harbin Medical University, Harbin 150081, ChinaBiotherapy Center, Affiliated Tumor Hospital of Harbin Medical University, Harbin 150081, ChinaPancreatic cancer (PC) is a highly malignant tumor of the digestive system. Due to the lack of sensitive and effective detection markers, the tumor is usually at a relatively advanced stage in initial diagnosis. Therefore, early detection of PC is crucial for timely treatment and better prognosis. Exosomes are extracellular vesicles secreted by cells. They have a lipid bimolecular membrane structure to ensure the stable existence of a large number of biologically active substances contained therein. So they can accurately reflect the characteristics of parental cells. Exosomes are widely present in various body fluids and can non-invasively, conveniently and real-timely extracted, with the potential to become a marker for early tumor diagnosis. Previous studies have shown that compared with traditional diagnostic methods, exosomes showed higher sensitivity and specificity in the early diagnosis of various cancers. This article reviews the research progress of exosomes in the early diagnosis of pancreatic cancer.http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2022.21.1008pancreatic carcinomadiagnosisexosomesliquid biopsy |
| spellingShingle | GUO Madi ZHAO Juan HUANG Xiaoyi Research Progress of Exosome-based Liquid Biopsy in Diagnosis of Pancreatic Cancer Zhongliu Fangzhi Yanjiu pancreatic carcinoma diagnosis exosomes liquid biopsy |
| title | Research Progress of Exosome-based Liquid Biopsy in Diagnosis of Pancreatic Cancer |
| title_full | Research Progress of Exosome-based Liquid Biopsy in Diagnosis of Pancreatic Cancer |
| title_fullStr | Research Progress of Exosome-based Liquid Biopsy in Diagnosis of Pancreatic Cancer |
| title_full_unstemmed | Research Progress of Exosome-based Liquid Biopsy in Diagnosis of Pancreatic Cancer |
| title_short | Research Progress of Exosome-based Liquid Biopsy in Diagnosis of Pancreatic Cancer |
| title_sort | research progress of exosome based liquid biopsy in diagnosis of pancreatic cancer |
| topic | pancreatic carcinoma diagnosis exosomes liquid biopsy |
| url | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2022.21.1008 |
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