Impact of Chemotherapy Regimens on Body Composition of Breast Cancer Women: A Multicenter Study across Four Brazilian Regions
This study aimed to investigate the effect of chemotherapy (CT) and its different types of regimens on the anthropometry and body composition of women with breast cancer. Three-hundred-and-four women with breast cancer were enrolled in this multicenter study. The participants were evaluated before t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/7/1689 |
| _version_ | 1797607254194651136 |
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| author | Jordana Carolina Marques Godinho-Mota Larissa Vaz-Gonçalves Isis Danyelle Dias Custódio Jaqueline Schroeder de Souza João Felipe Mota Maria Cristina Gonzalez Priscylla Rodrigues Vilella Karine Anusca Martins Yara Cristina de Paiva Maia Sara Maria Moreira Lima Verde Aline Porciúncula Frenzel Patricia Faria Di Pietro Eduarda da Costa Marinho Ruffo Freitas-Junior |
| author_facet | Jordana Carolina Marques Godinho-Mota Larissa Vaz-Gonçalves Isis Danyelle Dias Custódio Jaqueline Schroeder de Souza João Felipe Mota Maria Cristina Gonzalez Priscylla Rodrigues Vilella Karine Anusca Martins Yara Cristina de Paiva Maia Sara Maria Moreira Lima Verde Aline Porciúncula Frenzel Patricia Faria Di Pietro Eduarda da Costa Marinho Ruffo Freitas-Junior |
| author_sort | Jordana Carolina Marques Godinho-Mota |
| collection | DOAJ |
| description | This study aimed to investigate the effect of chemotherapy (CT) and its different types of regimens on the anthropometry and body composition of women with breast cancer. Three-hundred-and-four women with breast cancer were enrolled in this multicenter study. The participants were evaluated before the infusion of the first cycle of CT (pre-CT), and until two weeks after CT completion (post-CT), regarding body weight, body mass index (BMI); waist circumference (WC); waist-to-height ratio (WHtR); conicity index (C-index); fat mass index (FMI); and fat-free mass index (FFMI). CT regimens were classified as anthracycline-based (AC—doxorubicin or epirubicin); anthracyclines and taxane (ACT); cyclophosphamide, methotrexate, and 5-fluorouracil (CMF); or isolated taxanes (paclitaxel or docetaxel). Women significantly increased BMI and FMI post-CT (<i>p</i> < 0.001 and <i>p</i> = 0.007, respectively). The ACT regimen increased FMI (<i>p</i> < 0.001), while FFMI increased after AC (<i>p</i> = 0.007). It is concluded that the CT negatively impacted body composition and the type of regime had a strong influence. The ACT regimen promoted an increase in FMI compared to other regimens, and the AC increased FFMI. These findings reinforce the importance of nutritional monitoring of breast cancer patients throughout the entire CT treatment. |
| first_indexed | 2024-03-11T05:27:36Z |
| format | Article |
| id | doaj.art-47004d3a3091418a95d905bbe21b09f9 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T05:27:36Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-47004d3a3091418a95d905bbe21b09f92023-11-17T17:20:38ZengMDPI AGNutrients2072-66432023-03-01157168910.3390/nu15071689Impact of Chemotherapy Regimens on Body Composition of Breast Cancer Women: A Multicenter Study across Four Brazilian RegionsJordana Carolina Marques Godinho-Mota0Larissa Vaz-Gonçalves1Isis Danyelle Dias Custódio2Jaqueline Schroeder de Souza3João Felipe Mota4Maria Cristina Gonzalez5Priscylla Rodrigues Vilella6Karine Anusca Martins7Yara Cristina de Paiva Maia8Sara Maria Moreira Lima Verde9Aline Porciúncula Frenzel10Patricia Faria Di Pietro11Eduarda da Costa Marinho12Ruffo Freitas-Junior13Csentro Avançado de Diagnóstico da Mama, Clinics Hospital, Federal University of Goias, Goiania 74175-120, BrazilCsentro Avançado de Diagnóstico da Mama, Clinics Hospital, Federal University of Goias, Goiania 74175-120, BrazilFaculty of Medicine, Federal University of Uberlandia, Uberlandia 38408-100, BrazilPost Graduate Program in Nutrition, Federal University of Santa Catarina, Florianopolis 88040-900, BrazilNutrition Faculty, Federal University of Goias, Goiania 74690-900, BrazilPost-Graduate Program in Health and Behavior, Catholic University of Pelotas, Pelotas 96015-560, BrazilNutrition Faculty, Federal University of Goias, Goiania 74690-900, BrazilNutrition Faculty, Federal University of Goias, Goiania 74690-900, BrazilFaculty of Medicine, Federal University of Uberlandia, Uberlandia 38408-100, BrazilPost-Graduate Program in Nutrition and Health, State University of Ceara, Fortaleza 60714-903, BrazilPost-Graduate Program in Health and Behavior, Catholic University of Pelotas, Pelotas 96015-560, BrazilPost Graduate Program in Nutrition, Federal University of Santa Catarina, Florianopolis 88040-900, BrazilFaculty of Medicine, Federal University of Uberlandia, Uberlandia 38408-100, BrazilCsentro Avançado de Diagnóstico da Mama, Clinics Hospital, Federal University of Goias, Goiania 74175-120, BrazilThis study aimed to investigate the effect of chemotherapy (CT) and its different types of regimens on the anthropometry and body composition of women with breast cancer. Three-hundred-and-four women with breast cancer were enrolled in this multicenter study. The participants were evaluated before the infusion of the first cycle of CT (pre-CT), and until two weeks after CT completion (post-CT), regarding body weight, body mass index (BMI); waist circumference (WC); waist-to-height ratio (WHtR); conicity index (C-index); fat mass index (FMI); and fat-free mass index (FFMI). CT regimens were classified as anthracycline-based (AC—doxorubicin or epirubicin); anthracyclines and taxane (ACT); cyclophosphamide, methotrexate, and 5-fluorouracil (CMF); or isolated taxanes (paclitaxel or docetaxel). Women significantly increased BMI and FMI post-CT (<i>p</i> < 0.001 and <i>p</i> = 0.007, respectively). The ACT regimen increased FMI (<i>p</i> < 0.001), while FFMI increased after AC (<i>p</i> = 0.007). It is concluded that the CT negatively impacted body composition and the type of regime had a strong influence. The ACT regimen promoted an increase in FMI compared to other regimens, and the AC increased FFMI. These findings reinforce the importance of nutritional monitoring of breast cancer patients throughout the entire CT treatment.https://www.mdpi.com/2072-6643/15/7/1689breast canceradjuvant treatmentbody mass indexfat mass indexfat-free mass index |
| spellingShingle | Jordana Carolina Marques Godinho-Mota Larissa Vaz-Gonçalves Isis Danyelle Dias Custódio Jaqueline Schroeder de Souza João Felipe Mota Maria Cristina Gonzalez Priscylla Rodrigues Vilella Karine Anusca Martins Yara Cristina de Paiva Maia Sara Maria Moreira Lima Verde Aline Porciúncula Frenzel Patricia Faria Di Pietro Eduarda da Costa Marinho Ruffo Freitas-Junior Impact of Chemotherapy Regimens on Body Composition of Breast Cancer Women: A Multicenter Study across Four Brazilian Regions Nutrients breast cancer adjuvant treatment body mass index fat mass index fat-free mass index |
| title | Impact of Chemotherapy Regimens on Body Composition of Breast Cancer Women: A Multicenter Study across Four Brazilian Regions |
| title_full | Impact of Chemotherapy Regimens on Body Composition of Breast Cancer Women: A Multicenter Study across Four Brazilian Regions |
| title_fullStr | Impact of Chemotherapy Regimens on Body Composition of Breast Cancer Women: A Multicenter Study across Four Brazilian Regions |
| title_full_unstemmed | Impact of Chemotherapy Regimens on Body Composition of Breast Cancer Women: A Multicenter Study across Four Brazilian Regions |
| title_short | Impact of Chemotherapy Regimens on Body Composition of Breast Cancer Women: A Multicenter Study across Four Brazilian Regions |
| title_sort | impact of chemotherapy regimens on body composition of breast cancer women a multicenter study across four brazilian regions |
| topic | breast cancer adjuvant treatment body mass index fat mass index fat-free mass index |
| url | https://www.mdpi.com/2072-6643/15/7/1689 |
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